Gene name: HIS6
Reference locus (S288C): YIL020C
Gene biotype: protein_coding
Description: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
Top 10 interactors (score): HIS4 (0.999); HIS7 (0.999); HIS3 (0.986); HIS5 (0.983); TRP3 (0.957); TRP5 (0.951); HIS1 (0.905); VTI1 (0.788); RAD16 (0.766); TRP4 (0.754); TRP1 (0.745); URA3 (0.74); HSP104 (0.736); ARO1 (0.736); HIS2 (0.725); BAR1 (0.713); ARG5,6 (0.707); UBC9 (0.705); SEC18 (0.7); YDL186W (0.697)
Homologues (species, bitscore): APG10 (Arabidopsis thaliana, 210.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005303.1:312492-313277:- | gene-YIL020C_AKU4011 | rna-NM_001179370.3_AKU4011 | cds-NP_012244.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000164.1:172319-173104:- | gene-YIL020C_BG1 | rna-NM_001179370.3_BG1 | cds-NP_012244.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005511.1:317636-318421:- | gene-YIL020C_Bruggeman | rna-NM_001179370.3_Bruggeman | cds-NP_012244.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005527.1:305053-305838:- | gene-YIL020C_CAT1 | rna-NM_001179370.3_CAT1 | cds-NP_012244.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005367.1:312583-313368:- | gene-YIL020C_CBS1585 | rna-NM_001179370.3_CBS1585 | cds-NP_012244.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005351.1:306017-306802:- | gene-YIL020C_CBS436 | rna-NM_001179370.3_CBS436 | cds-NP_012244.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005335.1:308115-308900:- | gene-YIL020C_CBS6412 | rna-NM_001179370.3_CBS6412 | cds-NP_012244.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005319.1:304497-305282:- | gene-YIL020C_CBS6413 | rna-NM_001179370.3_CBS6413 | cds-NP_012244.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001530.1:305944-306729:- | gene-YIL020C_CENPK1137D | rna-NM_001179370.3_CENPK1137D | cds-NP_012244.3_CENPK1137D | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005479.1:295458-296243:- | gene-YIL020C_EthanolRed | rna-NM_001179370.3_EthanolRed | cds-NP_012244.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005543.1:313369-314154:- | gene-YIL020C_FaliES1 | rna-NM_001179370.3_FaliES1 | cds-NP_012244.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000098.1:2831-3616:+ | gene-YIL020C_JAY291 | rna-NM_001179370.3_JAY291 | cds-NP_012244.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005415.1:314487-315272:- | gene-YIL020C_MUCL30387 | rna-NM_001179370.3_MUCL30387 | cds-NP_012244.3_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005447.1:310592-311377:- | gene-YIL020C_MUCL30388 | rna-NM_001179370.3_MUCL30388 | cds-NP_012244.3_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005287.1:313172-313957:- | gene-YIL020C_MUCL39482 | rna-NM_001179370.3_MUCL39482 | cds-NP_012244.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005431.1:316307-317092:- | gene-YIL020C_MUCL42920 | rna-NM_001179370.3_MUCL42920 | cds-NP_012244.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011818.1:314035-314820:- | gene-YIL020C_NCIM3186 | rna-NM_001179370.3_NCIM3186 | cds-NP_012244.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005271.1:317445-318230:- | gene-YIL020C_NCYC1407 | rna-NM_001179370.3_NCYC1407 | cds-NP_012244.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994148.1:309088-309873:- | gene-YIL020C_PE2H3 | rna-NM_001179370.3_PE2H3 | cds-NP_012244.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999880.1:303794-304579:- | gene-YIL020C_PE2H4 | rna-NM_001179370.3_PE2H4 | cds-NP_012244.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001141.2:314035-314820:- | gene-YIL020C_S288C | rna-NM_001179370.3_S288C | cds-NP_012244.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000031.1:9711-10496:+ | gene-YIL020C_SA1 | rna-NM_001179370.3_SA1 | cds-NP_012244.3_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005495.1:312038-312823:- | gene-YIL020C_ThermosaccDry | rna-NM_001179370.3_ThermosaccDry | cds-NP_012244.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005463.1:308676-309461:- | gene-YIL020C_VR1 | rna-NM_001179370.3_VR1 | cds-NP_012244.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000019.1:286458-287243:- | gene-YIL020C_ZTW1 | rna-NM_001179370.3_ZTW1 | cds-NP_012244.3_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047495.1:307174-307959:- | gene-YIL020C_Sparadoxus | rna-NM_001179370.3_Sparadoxus | cds-NP_012244.3_Sparadoxus | 90.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |