Gene name: HIS4
Reference locus (S288C): YCL030C
Gene biotype: protein_coding
Description: Histidine biosynthesis trifunctional protein; Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
Top 10 interactors (score): HIS3 (0.999); HIS7 (0.999); HIS5 (0.999); HIS6 (0.999); HIS1 (0.999); ARG4 (0.994); TRP3 (0.993); HIS2 (0.992); ILV3 (0.979); TRP5 (0.977); ARG5,6 (0.977); TRP1 (0.969); ARG1 (0.968); URA3 (0.965); ADE6 (0.959); CPA2 (0.959); ALA1 (0.952); LYS2 (0.95); TPP1 (0.948); LEU2 (0.945)
Homologues (species, bitscore): HDH (Arabidopsis thaliana, 428.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005297.1:67297-69696:- | gene-YCL030C_AKU4011 | rna-NM_001178675.1_AKU4011 | cds-NP_009900.2_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000178.1:77416-79815:+ | gene-YCL030C_BG1 | rna-NM_001178675.1_BG1 | cds-NP_009900.2_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005505.1:55487-57886:- | gene-YCL030C_Bruggeman | rna-NM_001178675.1_Bruggeman | cds-NP_009900.2_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005521.1:67095-69494:- | gene-YCL030C_CAT1 | rna-NM_001178675.1_CAT1 | cds-NP_009900.2_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005361.1:67986-70385:- | gene-YCL030C_CBS1585 | rna-NM_001178675.1_CBS1585 | cds-NP_009900.2_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005345.1:66428-68827:- | gene-YCL030C_CBS436 | rna-NM_001178675.1_CBS436 | cds-NP_009900.2_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005329.1:55394-57793:- | gene-YCL030C_CBS6412 | rna-NM_001178675.1_CBS6412 | cds-NP_009900.2_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005313.1:66762-69161:- | gene-YCL030C_CBS6413 | rna-NM_001178675.1_CBS6413 | cds-NP_009900.2_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001524.1:65531-67930:- | gene-YCL030C_CENPK1137D | rna-NM_001178675.1_CENPK1137D | cds-NP_009900.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005473.1:65320-67719:- | gene-YCL030C_EthanolRed | rna-NM_001178675.1_EthanolRed | cds-NP_009900.2_EthanolRed | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005537.1:66262-68661:- | gene-YCL030C_FaliES1 | rna-NM_001178675.1_FaliES1 | cds-NP_009900.2_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000225.1:15725-18124:+ | gene-YCL030C_JAY291 | rna-NM_001178675.1_JAY291 | cds-NP_009900.2_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005409.1:53678-56077:- | gene-YCL030C_MUCL30387 | rna-NM_001178675.1_MUCL30387 | cds-NP_009900.2_MUCL30387 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005441.1:53952-56351:- | gene-YCL030C_MUCL30388 | rna-NM_001178675.1_MUCL30388 | cds-NP_009900.2_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005281.1:68355-70754:- | gene-YCL030C_MUCL39482 | rna-NM_001178675.1_MUCL39482 | cds-NP_009900.2_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005425.1:54468-56867:- | gene-YCL030C_MUCL42920 | rna-NM_001178675.1_MUCL42920 | cds-NP_009900.2_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011812.1:65566-67965:- | gene-YCL030C_NCIM3186 | rna-NM_001178675.1_NCIM3186 | cds-NP_009900.2_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005265.1:68845-71244:- | gene-YCL030C_NCYC1407 | rna-NM_001178675.1_NCYC1407 | cds-NP_009900.2_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994142.1:66387-68786:- | gene-YCL030C_PE2H3 | rna-NM_001178675.1_PE2H3 | cds-NP_009900.2_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999874.1:66344-68743:- | gene-YCL030C_PE2H4 | rna-NM_001178675.1_PE2H4 | cds-NP_009900.2_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001135.5:65934-68333:- | gene-YCL030C_S288C | rna-NM_001178675.1_S288C | cds-NP_009900.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000061.1:53070-55469:- | gene-YCL030C_SA1 | rna-NM_001178675.1_SA1 | cds-NP_009900.2_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005489.1:66581-68980:- | gene-YCL030C_ThermosaccDry | rna-NM_001178675.1_ThermosaccDry | cds-NP_009900.2_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005457.1:72877-75276:- | gene-YCL030C_VR1 | rna-NM_001178675.1_VR1 | cds-NP_009900.2_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000004.1:66776-69175:- | gene-YCL030C_ZTW1 | rna-NM_001178675.1_ZTW1 | cds-NP_009900.2_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047489.1:96302-98701:- | gene-YCL030C_Sparadoxus | rna-NM_001178675.1_Sparadoxus | cds-NP_009900.2_Sparadoxus | 92.0 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |