Gene name: HFD1
Reference locus (S288C): YMR110C
Gene biotype: protein_coding
Description: Fatty aldehyde dehydrogenase HFD1; Dehydrogenase involved in ubiquinone and sphingolipid metabolism; oxidizes 4-hydroxybenzaldehyde into 4-hydroxybenzoic acid in ubiquinone biosynthesis; converts hexadecenal to hexadecenoic acid in sphingosine 1-phosphate breakdown pathway; located in the mitochondrial outer membrane and also in lipid particles; human homolog ALDH3A2, a fatty aldehyde dehydrogenase (FALDH) mutated in neurocutaneous disorder Sjogren-Larsson syndrome, can complement yeast hfd1 mutant
Top 10 interactors (score): TDA10 (0.963); GAD1 (0.962); UGA1 (0.951); FMS1 (0.95); ACS1 (0.932); PXA1 (0.931); PXA2 (0.928); ACS2 (0.925); NDI1 (0.924); SYM1 (0.923); ACH1 (0.922); NDE2 (0.918); POS5 (0.906); FIS1 (0.905); NDE1 (0.904); NIT1 (0.904); AMD2 (0.904); PEX11 (0.904); GDH2 (0.903); YEF1 (0.903)
Homologues (species, bitscore): ALDH3A1 (Homo sapiens, 278.9); Aldh3a2 (Mus musculus, 266.9); aldh3a2b (Danio rerio, 287.7); aldh3a2 (Xenopus tropicalis, 280.4); Aldh-III (Drosophila melanogaster, 264.6); alh-4 (Caenorhabditis elegans, 294.7); ALDH3H1 (Arabidopsis thaliana, 267.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:528568-530166:- | gene-YMR110C_AKU4011 | rna-NM_001182610.1_AKU4011 | cds-NP_013828.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:12683-14281:+ | gene-YMR110C_BG1 | rna-NM_001182610.1_BG1 | cds-NP_013828.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:470753-472351:- | gene-YMR110C_Bruggeman | rna-NM_001182610.1_Bruggeman | cds-NP_013828.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:471058-472656:- | gene-YMR110C_CAT1 | rna-NM_001182610.1_CAT1 | cds-NP_013828.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:462011-463609:- | gene-YMR110C_CBS1585 | rna-NM_001182610.1_CBS1585 | cds-NP_013828.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:466926-468524:- | gene-YMR110C_CBS436 | rna-NM_001182610.1_CBS436 | cds-NP_013828.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:574619-576217:- | gene-YMR110C_CBS6412 | rna-NM_001182610.1_CBS6412 | cds-NP_013828.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:460772-462370:- | gene-YMR110C_CBS6413 | rna-NM_001182610.1_CBS6413 | cds-NP_013828.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:484920-486518:- | gene-YMR110C_CENPK1137D | rna-NM_001182610.1_CENPK1137D | cds-NP_013828.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:461399-462997:- | gene-YMR110C_EthanolRed | rna-NM_001182610.1_EthanolRed | cds-NP_013828.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:465409-467007:- | gene-YMR110C_FaliES1 | rna-NM_001182610.1_FaliES1 | cds-NP_013828.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000380.1:12562-14160:+ | gene-YMR110C_JAY291 | rna-NM_001182610.1_JAY291 | cds-NP_013828.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:467674-469272:- | gene-YMR110C_MUCL30387 | rna-NM_001182610.1_MUCL30387 | cds-NP_013828.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:471675-473273:- | gene-YMR110C_MUCL30388 | rna-NM_001182610.1_MUCL30388 | cds-NP_013828.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:461812-463410:- | gene-YMR110C_MUCL39482 | rna-NM_001182610.1_MUCL39482 | cds-NP_013828.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:468578-470176:- | gene-YMR110C_MUCL42920 | rna-NM_001182610.1_MUCL42920 | cds-NP_013828.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:490348-491946:- | gene-YMR110C_NCIM3186 | rna-NM_001182610.1_NCIM3186 | cds-NP_013828.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:461708-463306:- | gene-YMR110C_NCYC1407 | rna-NM_001182610.1_NCYC1407 | cds-NP_013828.1_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:467523-469121:- | gene-YMR110C_PE2H3 | rna-NM_001182610.1_PE2H3 | cds-NP_013828.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:473618-475216:- | gene-YMR110C_PE2H4 | rna-NM_001182610.1_PE2H4 | cds-NP_013828.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:490394-491992:- | gene-YMR110C_S288C | rna-NM_001182610.1_S288C | cds-NP_013828.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000048.1:79602-81200:+ | gene-YMR110C_SA1 | rna-NM_001182610.1_SA1 | cds-NP_013828.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:462385-463983:- | gene-YMR110C_ThermosaccDry | rna-NM_001182610.1_ThermosaccDry | cds-NP_013828.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:474109-475707:- | gene-YMR110C_VR1 | rna-NM_001182610.1_VR1 | cds-NP_013828.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:438418-440016:- | gene-YMR110C_ZTW1 | rna-NM_001182610.1_ZTW1 | cds-NP_013828.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:475408-477006:- | gene-YMR110C_Sparadoxus | rna-NM_001182610.1_Sparadoxus | cds-NP_013828.1_Sparadoxus | 87.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |