Gene name: HFA1
Reference locus (S288C): YMR207C
Gene biotype: protein_coding
Description: Acetyl-CoA carboxylase, mitochondrial; Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical (Ile) start codon at -372 relative to the annotated start codon
Top 10 interactors (score): FAS2 (0.99); FAS1 (0.99); ACS2 (0.97); MCT1 (0.969); BPL1 (0.967); ACS1 (0.957); ACC1 (0.932); ACH1 (0.931); ERG10 (0.929); LAT1 (0.918); LEU9 (0.913); LYS20 (0.913); LEU4 (0.913); LYS21 (0.913); DAL7 (0.9); LSC2 (0.9); MLS1 (0.9); CIT2 (0.864); CEM1 (0.863); CIT1 (0.851)
Homologues (species, bitscore): ACACA (Homo sapiens, 1714.1); Acaca (Mus musculus, 1715.3); acaca (Danio rerio, 1728.0); acaca (Xenopus tropicalis, 1695.2); ACC (Drosophila melanogaster, 1613.2); pod-2 (Caenorhabditis elegans, 1024.2); ACC1 (Arabidopsis thaliana, 1454.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:717118-723489:- | gene-YMR207C_AKU4011 | rna-NM_001182714.1_AKU4011 | cds-NP_013934.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:231118-237489:+ | gene-YMR207C_BG1 | rna-NM_001182714.1_BG1 | cds-NP_013934.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:661333-667704:- | gene-YMR207C_Bruggeman | rna-NM_001182714.1_Bruggeman | cds-NP_013934.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:664588-670959:- | gene-YMR207C_CAT1 | rna-NM_001182714.1_CAT1 | cds-NP_013934.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:649380-655751:- | gene-YMR207C_CBS1585 | rna-NM_001182714.1_CBS1585 | cds-NP_013934.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:653632-660003:- | gene-YMR207C_CBS436 | rna-NM_001182714.1_CBS436 | cds-NP_013934.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:760937-767308:- | gene-YMR207C_CBS6412 | rna-NM_001182714.1_CBS6412 | cds-NP_013934.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:648528-654899:- | gene-YMR207C_CBS6413 | rna-NM_001182714.1_CBS6413 | cds-NP_013934.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:671917-678288:- | gene-YMR207C_CENPK1137D | rna-NM_001182714.1_CENPK1137D | cds-NP_013934.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:709584-715955:- | gene-YMR207C_EthanolRed | rna-NM_001182714.1_EthanolRed | cds-NP_013934.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:655236-661607:- | gene-YMR207C_FaliES1 | rna-NM_001182714.1_FaliES1 | cds-NP_013934.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000141.1:124430-130801:+ | gene-YMR207C_JAY291 | rna-NM_001182714.1_JAY291 | cds-NP_013934.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:654880-661251:- | gene-YMR207C_MUCL30387 | rna-NM_001182714.1_MUCL30387 | cds-NP_013934.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:661657-668028:- | gene-YMR207C_MUCL30388 | rna-NM_001182714.1_MUCL30388 | cds-NP_013934.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:650450-656821:- | gene-YMR207C_MUCL39482 | rna-NM_001182714.1_MUCL39482 | cds-NP_013934.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:657775-664146:- | gene-YMR207C_MUCL42920 | rna-NM_001182714.1_MUCL42920 | cds-NP_013934.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:677147-683518:- | gene-YMR207C_NCIM3186 | rna-NM_001182714.1_NCIM3186 | cds-NP_013934.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:650102-656473:- | gene-YMR207C_NCYC1407 | rna-NM_001182714.1_NCYC1407 | cds-NP_013934.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:659949-666320:- | gene-YMR207C_PE2H3 | rna-NM_001182714.1_PE2H3 | cds-NP_013934.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:660964-667335:- | gene-YMR207C_PE2H4 | rna-NM_001182714.1_PE2H4 | cds-NP_013934.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:677193-683564:- | gene-YMR207C_S288C | rna-NM_001182714.1_S288C | cds-NP_013934.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:124542-130913:+ | gene-YMR207C_SA1 | rna-NM_001182714.1_SA1 | cds-NP_013934.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:651407-657778:- | gene-YMR207C_ThermosaccDry | rna-NM_001182714.1_ThermosaccDry | cds-NP_013934.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:664475-670846:- | gene-YMR207C_VR1 | rna-NM_001182714.1_VR1 | cds-NP_013934.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000028.1:67111-73482:- | gene-YMR207C_ZTW1 | rna-NM_001182714.1_ZTW1 | cds-NP_013934.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:669173-675543:- | gene-YMR207C_Sparadoxus | rna-NM_001182714.1_Sparadoxus | cds-NP_013934.1_Sparadoxus | 87.8 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |