Gene name: HEM4
Reference locus (S288C): YOR278W
Gene biotype: protein_coding
Description: Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
Top 10 interactors (score): HEM3 (0.999); HEM2 (0.998); HEM12 (0.998); HEM1 (0.991); HEM15 (0.981); HEM14 (0.979); HEM13 (0.979); MET1 (0.96); ERG25 (0.932); ERG11 (0.912); ISA1 (0.84); ERG3 (0.783); HEM25 (0.781); BCP1 (0.756); LIP5 (0.73); YDR042C (0.716); HMX1 (0.705); CTO1 (0.697); COX10 (0.677); MTM1 (0.664)
Homologues (species, bitscore): UROS (Homo sapiens, 70.1); Uros (Mus musculus, 70.5); uros (Danio rerio, 70.1); uros (Xenopus tropicalis, 60.1); CG1885 (Drosophila melanogaster, 63.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:833627-834454:+ | gene-YOR278W_AKU4011 | rna-NM_001183697.1_AKU4011 | cds-NP_014921.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:235590-236417:+ | gene-YOR278W_BG1 | rna-NM_001183697.1_BG1 | cds-NP_014921.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:819060-819887:+ | gene-YOR278W_Bruggeman | rna-NM_001183697.1_Bruggeman | cds-NP_014921.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:819731-820558:+ | gene-YOR278W_CAT1 | rna-NM_001183697.1_CAT1 | cds-NP_014921.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:816645-817472:+ | gene-YOR278W_CBS1585 | rna-NM_001183697.1_CBS1585 | cds-NP_014921.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:815292-816119:+ | gene-YOR278W_CBS436 | rna-NM_001183697.1_CBS436 | cds-NP_014921.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:813498-814325:+ | gene-YOR278W_CBS6412 | rna-NM_001183697.1_CBS6412 | cds-NP_014921.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:822356-823183:+ | gene-YOR278W_CBS6413 | rna-NM_001183697.1_CBS6413 | cds-NP_014921.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:842587-843414:+ | gene-YOR278W_CENPK1137D | rna-NM_001183697.1_CENPK1137D | cds-NP_014921.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:809754-810581:+ | gene-YOR278W_EthanolRed | rna-NM_001183697.1_EthanolRed | cds-NP_014921.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:815153-815980:+ | gene-YOR278W_FaliES1 | rna-NM_001183697.1_FaliES1 | cds-NP_014921.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000381.1:10936-11763:- | gene-YOR278W_JAY291 | rna-NM_001183697.1_JAY291 | cds-NP_014921.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:823297-824124:+ | gene-YOR278W_MUCL30387 | rna-NM_001183697.1_MUCL30387 | cds-NP_014921.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:831274-832101:+ | gene-YOR278W_MUCL30388 | rna-NM_001183697.1_MUCL30388 | cds-NP_014921.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:823991-824818:+ | gene-YOR278W_MUCL39482 | rna-NM_001183697.1_MUCL39482 | cds-NP_014921.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:833476-834303:+ | gene-YOR278W_MUCL42920 | rna-NM_001183697.1_MUCL42920 | cds-NP_014921.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:842706-843533:+ | gene-YOR278W_NCIM3186 | rna-NM_001183697.1_NCIM3186 | cds-NP_014921.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:824196-825023:+ | gene-YOR278W_NCYC1407 | rna-NM_001183697.1_NCYC1407 | cds-NP_014921.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:823272-824099:+ | gene-YOR278W_PE2H3 | rna-NM_001183697.1_PE2H3 | cds-NP_014921.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:833649-834476:+ | gene-YOR278W_PE2H4 | rna-NM_001183697.1_PE2H4 | cds-NP_014921.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:842817-843644:+ | gene-YOR278W_S288C | rna-NM_001183697.1_S288C | cds-NP_014921.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:252833-253660:+ | gene-YOR278W_SA1 | rna-NM_001183697.1_SA1 | cds-NP_014921.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:814336-815163:+ | gene-YOR278W_ThermosaccDry | rna-NM_001183697.1_ThermosaccDry | cds-NP_014921.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:877712-878539:+ | gene-YOR278W_VR1 | rna-NM_001183697.1_VR1 | cds-NP_014921.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:547224-548051:+ | gene-YOR278W_ZTW1 | rna-NM_001183697.1_ZTW1 | cds-NP_014921.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:819992-820819:+ | gene-YOR278W_Sparadoxus | rna-NM_001183697.1_Sparadoxus | cds-NP_014921.1_Sparadoxus | 85.0 | 99.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |