Gene name: HEM3
Reference locus (S288C): YDL205C
Gene biotype: protein_coding
Description: Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid
Top 10 interactors (score): HEM4 (0.999); HEM12 (0.999); HEM2 (0.999); HEM1 (0.992); HEM14 (0.986); HEM13 (0.985); HEM15 (0.976); MET1 (0.941); ERG1 (0.922); ERG26 (0.901); ISA1 (0.836); OLE1 (0.745); COQ3 (0.742); HMX1 (0.73); GCD7 (0.686); ERG7 (0.675); HEM25 (0.672); MRPL23 (0.665); COX10 (0.655); COQ2 (0.645)
Homologues (species, bitscore): HMBS (Homo sapiens, 242.7); Hmbs (Mus musculus, 235.3); hmbsb (Danio rerio, 241.1); hmbs (Xenopus tropicalis, 207.2); l(3)02640 (Drosophila melanogaster, 215.7); HEMC (Arabidopsis thaliana, 155.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:76246-77229:- | gene-YDL205C_AKU4011 | rna-NM_001180265.1_AKU4011 | cds-NP_010076.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:471438-472421:+ | gene-YDL205C_BG1 | rna-NM_001180265.1_BG1 | cds-NP_010076.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:92626-93609:- | gene-YDL205C_Bruggeman | rna-NM_001180265.1_Bruggeman | cds-NP_010076.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:94749-95732:- | gene-YDL205C_CAT1 | rna-NM_001180265.1_CAT1 | cds-NP_010076.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:75097-76080:- | gene-YDL205C_CBS1585 | rna-NM_001180265.1_CBS1585 | cds-NP_010076.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:290002-290985:- | gene-YDL205C_CBS436 | rna-NM_001180265.1_CBS436 | cds-NP_010076.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:75211-76194:- | gene-YDL205C_CBS6412 | rna-NM_001180265.1_CBS6412 | cds-NP_010076.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:92755-93738:- | gene-YDL205C_CBS6413 | rna-NM_001180265.1_CBS6413 | cds-NP_010076.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:91428-92411:- | gene-YDL205C_CENPK1137D | rna-NM_001180265.1_CENPK1137D | cds-NP_010076.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:88896-89879:- | gene-YDL205C_EthanolRed | rna-NM_001180265.1_EthanolRed | cds-NP_010076.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:93502-94485:- | gene-YDL205C_FaliES1 | rna-NM_001180265.1_FaliES1 | cds-NP_010076.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000344.1:24763-25746:+ | gene-YDL205C_JAY291 | rna-NM_001180265.1_JAY291 | cds-NP_010076.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:90873-91856:- | gene-YDL205C_MUCL30387 | rna-NM_001180265.1_MUCL30387 | cds-NP_010076.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:80442-81425:- | gene-YDL205C_MUCL30388 | rna-NM_001180265.1_MUCL30388 | cds-NP_010076.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:75941-76924:- | gene-YDL205C_MUCL39482 | rna-NM_001180265.1_MUCL39482 | cds-NP_010076.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:92017-93000:- | gene-YDL205C_MUCL42920 | rna-NM_001180265.1_MUCL42920 | cds-NP_010076.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:92685-93668:- | gene-YDL205C_NCIM3186 | rna-NM_001180265.1_NCIM3186 | cds-NP_010076.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:75898-76881:- | gene-YDL205C_NCYC1407 | rna-NM_001180265.1_NCYC1407 | cds-NP_010076.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:83652-84635:- | gene-YDL205C_PE2H3 | rna-NM_001180265.1_PE2H3 | cds-NP_010076.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:83662-84645:- | gene-YDL205C_PE2H4 | rna-NM_001180265.1_PE2H4 | cds-NP_010076.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:92762-93745:- | gene-YDL205C_S288C | rna-NM_001180265.1_S288C | cds-NP_010076.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000090.1:7255-8238:- | gene-YDL205C_SA1 | rna-NM_001180265.1_SA1 | cds-NP_010076.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:93261-94244:- | gene-YDL205C_ThermosaccDry | rna-NM_001180265.1_ThermosaccDry | cds-NP_010076.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:94202-95185:- | gene-YDL205C_VR1 | rna-NM_001180265.1_VR1 | cds-NP_010076.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:91940-92923:- | gene-YDL205C_ZTW1 | rna-NM_001180265.1_ZTW1 | cds-NP_010076.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:95310-96293:- | gene-YDL205C_Sparadoxus | rna-NM_001180265.1_Sparadoxus | cds-NP_010076.1_Sparadoxus | 91.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |