Gene name: HEM25
Reference locus (S288C): YDL119C
Gene biotype: protein_coding
Description: Solute carrier family 25 member 38 homolog; Mitochondrial glycine transporter; required for the transport of glycine into mitochondria for initiation of heme biosynthesis, with YMC1 acting as a secondary transporter; homolog of human SLC25A38, a mitochondrial glycine transporter associated with nonsyndromic autosomal recessive congenital sideroblastic anemia; human SLC25A38 can complement the heme deficiency associated with the null mutant; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily
Top 10 interactors (score): HEM14 (0.941); HEM2 (0.888); HEM1 (0.886); MCX1 (0.801); HEM12 (0.795); HEM4 (0.781); YFR045W (0.771); GRX5 (0.76); ATM1 (0.756); PET8 (0.756); HEM15 (0.751); YNR040W (0.747); HEM13 (0.705); YMC1 (0.701); YJR120W (0.696); RDL2 (0.675); HEM3 (0.672); FMP10 (0.671); RPS0A (0.647); RPS0B (0.647)
Homologues (species, bitscore): SLC25A38 (Homo sapiens, 142.1); Slc25a38 (Mus musculus, 145.6); slc25a38a (Danio rerio, 142.1); slc25a38 (Xenopus tropicalis, 139.4); aralar1 (Drosophila melanogaster, 82.4); K01C8.7 (Caenorhabditis elegans, 86.7); AT2G30160 (Arabidopsis thaliana, 84.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:231314-232237:- | gene-YDL119C_AKU4011 | rna-NM_001180178.1_AKU4011 | cds-NP_010164.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:317715-318638:+ | gene-YDL119C_BG1 | rna-NM_001180178.1_BG1 | cds-NP_010164.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:248722-249645:- | gene-YDL119C_Bruggeman | rna-NM_001180178.1_Bruggeman | cds-NP_010164.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:245465-246388:- | gene-YDL119C_CAT1 | rna-NM_001180178.1_CAT1 | cds-NP_010164.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:229575-230498:- | gene-YDL119C_CBS1585 | rna-NM_001180178.1_CBS1585 | cds-NP_010164.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:246231-247154:- | gene-YDL119C_CBS436 | rna-NM_001180178.1_CBS436 | cds-NP_010164.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:228000-228923:- | gene-YDL119C_CBS6412 | rna-NM_001180178.1_CBS6412 | cds-NP_010164.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:247735-248658:- | gene-YDL119C_CBS6413 | rna-NM_001180178.1_CBS6413 | cds-NP_010164.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:245461-246384:- | gene-YDL119C_CENPK1137D | rna-NM_001180178.1_CENPK1137D | cds-NP_010164.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:242339-243262:- | gene-YDL119C_EthanolRed | rna-NM_001180178.1_EthanolRed | cds-NP_010164.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:248309-249232:- | gene-YDL119C_FaliES1 | rna-NM_001180178.1_FaliES1 | cds-NP_010164.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000010.1:18353-19276:- | gene-YDL119C_JAY291 | rna-NM_001180178.1_JAY291 | cds-NP_010164.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:246509-247432:- | gene-YDL119C_MUCL30387 | rna-NM_001180178.1_MUCL30387 | cds-NP_010164.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:237267-238190:- | gene-YDL119C_MUCL30388 | rna-NM_001180178.1_MUCL30388 | cds-NP_010164.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:230679-231602:- | gene-YDL119C_MUCL39482 | rna-NM_001180178.1_MUCL39482 | cds-NP_010164.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:152461-153384:- | gene-YDL119C_MUCL42920 | rna-NM_001180178.1_MUCL42920 | cds-NP_010164.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:246612-247535:- | gene-YDL119C_NCIM3186 | rna-NM_001180178.1_NCIM3186 | cds-NP_010164.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:230708-231631:- | gene-YDL119C_NCYC1407 | rna-NM_001180178.1_NCYC1407 | cds-NP_010164.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:237464-238387:- | gene-YDL119C_PE2H3 | rna-NM_001180178.1_PE2H3 | cds-NP_010164.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:237468-238391:- | gene-YDL119C_PE2H4 | rna-NM_001180178.1_PE2H4 | cds-NP_010164.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:246689-247612:- | gene-YDL119C_S288C | rna-NM_001180178.1_S288C | cds-NP_010164.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:187299-188222:+ | gene-YDL119C_SA1 | rna-NM_001180178.1_SA1 | cds-NP_010164.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:247820-248743:- | gene-YDL119C_ThermosaccDry | rna-NM_001180178.1_ThermosaccDry | cds-NP_010164.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:249926-250849:- | gene-YDL119C_VR1 | rna-NM_001180178.1_VR1 | cds-NP_010164.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:245749-246672:- | gene-YDL119C_ZTW1 | rna-NM_001180178.1_ZTW1 | cds-NP_010164.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:247851-248774:- | gene-YDL119C_Sparadoxus | rna-NM_001180178.1_Sparadoxus | cds-NP_010164.1_Sparadoxus | 89.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |