Gene name: HEM2
Reference locus (S288C): YGL040C
Gene biotype: protein_coding
Description: Delta-aminolevulinic acid dehydratase; Aminolevulinate dehydratase; a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus; human homolog ALAD can complement yeast hem2 mutant
Top 10 interactors (score): HEM3 (0.999); HEM1 (0.998); HEM4 (0.998); HEM12 (0.991); HEM15 (0.979); HEM14 (0.976); HEM13 (0.95); ERG25 (0.932); ERG11 (0.908); MNP1 (0.905); HEM25 (0.888); EHD3 (0.878); RDL2 (0.86); IPP1 (0.852); PUF3 (0.849); MET1 (0.833); MRP1 (0.793); ERG3 (0.78); ATP2 (0.777); HMX1 (0.762)
Homologues (species, bitscore): ALAD (Homo sapiens, 356.3); Alad (Mus musculus, 353.2); alad (Danio rerio, 337.8); alad (Xenopus tropicalis, 311.2); Pbgs (Drosophila melanogaster, 315.5); HEMB1 (Arabidopsis thaliana, 188.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:421595-422623:- | gene-YGL040C_AKU4011 | rna-NM_001180905.1_AKU4011 | cds-NP_011475.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000060.1:153506-154534:+ | gene-YGL040C_BG1 | rna-NM_001180905.1_BG1 | cds-NP_011475.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:422418-423446:- | gene-YGL040C_Bruggeman | rna-NM_001180905.1_Bruggeman | cds-NP_011475.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:420579-421607:- | gene-YGL040C_CAT1 | rna-NM_001180905.1_CAT1 | cds-NP_011475.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:423058-424086:- | gene-YGL040C_CBS1585 | rna-NM_001180905.1_CBS1585 | cds-NP_011475.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:417197-418225:- | gene-YGL040C_CBS436 | rna-NM_001180905.1_CBS436 | cds-NP_011475.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:415731-416759:- | gene-YGL040C_CBS6412 | rna-NM_001180905.1_CBS6412 | cds-NP_011475.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:419776-420804:- | gene-YGL040C_CBS6413 | rna-NM_001180905.1_CBS6413 | cds-NP_011475.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:419368-420396:- | gene-YGL040C_CENPK1137D | rna-NM_001180905.1_CENPK1137D | cds-NP_011475.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:409977-411005:- | gene-YGL040C_EthanolRed | rna-NM_001180905.1_EthanolRed | cds-NP_011475.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:413239-414267:- | gene-YGL040C_FaliES1 | rna-NM_001180905.1_FaliES1 | cds-NP_011475.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000165.1:2563-3591:+ | gene-YGL040C_JAY291 | rna-NM_001180905.1_JAY291 | cds-NP_011475.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:419374-420402:- | gene-YGL040C_MUCL30387 | rna-NM_001180905.1_MUCL30387 | cds-NP_011475.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:422418-423446:- | gene-YGL040C_MUCL30388 | rna-NM_001180905.1_MUCL30388 | cds-NP_011475.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:418852-419880:- | gene-YGL040C_MUCL39482 | rna-NM_001180905.1_MUCL39482 | cds-NP_011475.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:427271-428299:- | gene-YGL040C_MUCL42920 | rna-NM_001180905.1_MUCL42920 | cds-NP_011475.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:419527-420555:- | gene-YGL040C_NCIM3186 | rna-NM_001180905.1_NCIM3186 | cds-NP_011475.1_NCIM3186 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:412980-414008:- | gene-YGL040C_NCYC1407 | rna-NM_001180905.1_NCYC1407 | cds-NP_011475.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:415556-416584:- | gene-YGL040C_PE2H3 | rna-NM_001180905.1_PE2H3 | cds-NP_011475.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:420606-421634:- | gene-YGL040C_PE2H4 | rna-NM_001180905.1_PE2H4 | cds-NP_011475.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:419527-420555:- | gene-YGL040C_S288C | rna-NM_001180905.1_S288C | cds-NP_011475.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000021.1:135073-136101:+ | gene-YGL040C_SA1 | rna-NM_001180905.1_SA1 | cds-NP_011475.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:432605-433633:- | gene-YGL040C_ThermosaccDry | rna-NM_001180905.1_ThermosaccDry | cds-NP_011475.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:522543-523571:- | gene-YGL040C_VR1 | rna-NM_001180905.1_VR1 | cds-NP_011475.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:411178-412206:- | gene-YGL040C_ZTW1 | rna-NM_001180905.1_ZTW1 | cds-NP_011475.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:420782-421810:- | gene-YGL040C_Sparadoxus | rna-NM_001180905.1_Sparadoxus | cds-NP_011475.1_Sparadoxus | 91.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |