Gene name: HEM15
Reference locus (S288C): YOR176W
Gene biotype: protein_coding
Description: Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid
Top 10 interactors (score): YFH1 (0.998); HEM14 (0.998); HEM12 (0.99); HEM1 (0.988); HEM13 (0.985); HEM4 (0.981); COX10 (0.979); HEM2 (0.979); HEM3 (0.976); ATM1 (0.934); CYC3 (0.914); ISA1 (0.903); CYT2 (0.901); HMX1 (0.882); ACO1 (0.854); ISU1 (0.848); ISA2 (0.828); LIP5 (0.799); HEM25 (0.751); NFU1 (0.75)
Homologues (species, bitscore): FECH (Homo sapiens, 360.9); Fech (Mus musculus, 367.5); fech (Danio rerio, 379.8); fech (Xenopus tropicalis, 366.3); FeCH (Drosophila melanogaster, 299.7); FC-II (Arabidopsis thaliana, 202.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:660040-661221:+ | gene-YOR176W_AKU4011 | rna-NM_001183595.3_AKU4011 | cds-NP_014819.3_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:61794-62975:+ | gene-YOR176W_BG1 | rna-NM_001183595.3_BG1 | cds-NP_014819.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:644112-645293:+ | gene-YOR176W_Bruggeman | rna-NM_001183595.3_Bruggeman | cds-NP_014819.3_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:644132-645313:+ | gene-YOR176W_CAT1 | rna-NM_001183595.3_CAT1 | cds-NP_014819.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:642535-643716:+ | gene-YOR176W_CBS1585 | rna-NM_001183595.3_CBS1585 | cds-NP_014819.3_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:640829-642010:+ | gene-YOR176W_CBS436 | rna-NM_001183595.3_CBS436 | cds-NP_014819.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:640147-641328:+ | gene-YOR176W_CBS6412 | rna-NM_001183595.3_CBS6412 | cds-NP_014819.3_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:648828-650009:+ | gene-YOR176W_CBS6413 | rna-NM_001183595.3_CBS6413 | cds-NP_014819.3_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:662155-663336:+ | gene-YOR176W_CENPK1137D | rna-NM_001183595.3_CENPK1137D | cds-NP_014819.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:636243-637424:+ | gene-YOR176W_EthanolRed | rna-NM_001183595.3_EthanolRed | cds-NP_014819.3_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:641096-642277:+ | gene-YOR176W_FaliES1 | rna-NM_001183595.3_FaliES1 | cds-NP_014819.3_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000070.1:1267-2448:- | gene-YOR176W_JAY291 | rna-NM_001183595.3_JAY291 | cds-NP_014819.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:648919-650100:+ | gene-YOR176W_MUCL30387 | rna-NM_001183595.3_MUCL30387 | cds-NP_014819.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:655683-656864:+ | gene-YOR176W_MUCL30388 | rna-NM_001183595.3_MUCL30388 | cds-NP_014819.3_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:650376-651557:+ | gene-YOR176W_MUCL39482 | rna-NM_001183595.3_MUCL39482 | cds-NP_014819.3_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:659797-660978:+ | gene-YOR176W_MUCL42920 | rna-NM_001183595.3_MUCL42920 | cds-NP_014819.3_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:662290-663471:+ | gene-YOR176W_NCIM3186 | rna-NM_001183595.3_NCIM3186 | cds-NP_014819.3_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:650462-651643:+ | gene-YOR176W_NCYC1407 | rna-NM_001183595.3_NCYC1407 | cds-NP_014819.3_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:648971-650152:+ | gene-YOR176W_PE2H3 | rna-NM_001183595.3_PE2H3 | cds-NP_014819.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:659348-660529:+ | gene-YOR176W_PE2H4 | rna-NM_001183595.3_PE2H4 | cds-NP_014819.3_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:662401-663582:+ | gene-YOR176W_S288C | rna-NM_001183595.3_S288C | cds-NP_014819.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:78959-80140:+ | gene-YOR176W_SA1 | rna-NM_001183595.3_SA1 | cds-NP_014819.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:640279-641460:+ | gene-YOR176W_ThermosaccDry | rna-NM_001183595.3_ThermosaccDry | cds-NP_014819.3_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:703976-705157:+ | gene-YOR176W_VR1 | rna-NM_001183595.3_VR1 | cds-NP_014819.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:373731-374912:+ | gene-YOR176W_ZTW1 | rna-NM_001183595.3_ZTW1 | cds-NP_014819.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:645253-646434:+ | gene-YOR176W_Sparadoxus | rna-NM_001183595.3_Sparadoxus | cds-NP_014819.3_Sparadoxus | 90.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |