Gene name: HEM14
Reference locus (S288C): YER014W
Gene biotype: protein_coding
Description: Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides
Top 10 interactors (score): HEM13 (0.999); HEM15 (0.998); HEM12 (0.998); HEM3 (0.986); HEM4 (0.979); HEM2 (0.976); HEM1 (0.972); HEM25 (0.941); ATM1 (0.791); COX15 (0.781); YJR085C (0.774); HMX1 (0.76); FLX1 (0.717); LSC2 (0.686); COX10 (0.68); MDL1 (0.654); MDL2 (0.654); COQ3 (0.646); RAD14 (0.615); ERG9 (0.611)
Homologues (species, bitscore): PPOX (Homo sapiens, 122.5); Ppox (Mus musculus, 127.1); ppox (Danio rerio, 124.8); ppox (Xenopus tropicalis, 94.0); Ppox (Drosophila melanogaster, 144.1); PPOP1 (Arabidopsis thaliana, 68.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:176645-178264:+ | gene-YER014W_AKU4011 | rna-NM_001178905.1_AKU4011 | cds-NP_010930.1_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:247835-249454:- | gene-YER014W_BG1 | rna-NM_001178905.1_BG1 | cds-NP_010930.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:184504-186123:+ | gene-YER014W_Bruggeman | rna-NM_001178905.1_Bruggeman | cds-NP_010930.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:179146-180765:+ | gene-YER014W_CAT1 | rna-NM_001178905.1_CAT1 | cds-NP_010930.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:176568-178187:+ | gene-YER014W_CBS1585 | rna-NM_001178905.1_CBS1585 | cds-NP_010930.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:178142-179761:+ | gene-YER014W_CBS436 | rna-NM_001178905.1_CBS436 | cds-NP_010930.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:176812-178431:+ | gene-YER014W_CBS6412 | rna-NM_001178905.1_CBS6412 | cds-NP_010930.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:181598-183217:+ | gene-YER014W_CBS6413 | rna-NM_001178905.1_CBS6413 | cds-NP_010930.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:180462-182081:+ | gene-YER014W_CENPK1137D | rna-NM_001178905.1_CENPK1137D | cds-NP_010930.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:177271-178890:+ | gene-YER014W_EthanolRed | rna-NM_001178905.1_EthanolRed | cds-NP_010930.1_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:177531-179150:+ | gene-YER014W_FaliES1 | rna-NM_001178905.1_FaliES1 | cds-NP_010930.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000024.1:44157-45776:+ | gene-YER014W_JAY291 | rna-NM_001178905.1_JAY291 | cds-NP_010930.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:180697-182316:+ | gene-YER014W_MUCL30387 | rna-NM_001178905.1_MUCL30387 | cds-NP_010930.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:176972-178591:+ | gene-YER014W_MUCL30388 | rna-NM_001178905.1_MUCL30388 | cds-NP_010930.1_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:175611-177230:+ | gene-YER014W_MUCL39482 | rna-NM_001178905.1_MUCL39482 | cds-NP_010930.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:181728-183347:+ | gene-YER014W_MUCL42920 | rna-NM_001178905.1_MUCL42920 | cds-NP_010930.1_MUCL42920 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:182599-184218:+ | gene-YER014W_NCIM3186 | rna-NM_001178905.1_NCIM3186 | cds-NP_010930.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:180683-182302:+ | gene-YER014W_NCYC1407 | rna-NM_001178905.1_NCYC1407 | cds-NP_010930.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:184984-186603:+ | gene-YER014W_PE2H3 | rna-NM_001178905.1_PE2H3 | cds-NP_010930.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:180899-182518:+ | gene-YER014W_PE2H4 | rna-NM_001178905.1_PE2H4 | cds-NP_010930.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:182600-184219:+ | gene-YER014W_S288C | rna-NM_001178905.1_S288C | cds-NP_010930.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000020.1:59451-61070:- | gene-YER014W_SA1 | rna-NM_001178905.1_SA1 | cds-NP_010930.1_SA1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:178302-179921:+ | gene-YER014W_ThermosaccDry | rna-NM_001178905.1_ThermosaccDry | cds-NP_010930.1_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:177043-178662:+ | gene-YER014W_VR1 | rna-NM_001178905.1_VR1 | cds-NP_010930.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:175514-177133:+ | gene-YER014W_ZTW1 | rna-NM_001178905.1_ZTW1 | cds-NP_010930.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:180122-181741:+ | gene-YER014W_Sparadoxus | rna-NM_001178905.1_Sparadoxus | cds-NP_010930.1_Sparadoxus | 88.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |