Gene name: HEM13
Reference locus (S288C): YDR044W
Gene biotype: protein_coding
Description: Oxygen-dependent coproporphyrinogen-III oxidase; Coproporphyrinogen III oxidase; oxygen-requiring enzyme that catalyzes sixth step in heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); human homolog CPOX can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid; Belongs to the aerobic coproporphyrinogen-III oxidase family
Top 10 interactors (score): HEM12 (0.999); HEM14 (0.999); HEM3 (0.985); HEM15 (0.985); HEM4 (0.979); HEM1 (0.976); ERG1 (0.952); HEM2 (0.95); ANB1 (0.947); ROX1 (0.902); HMX1 (0.901); ERG25 (0.89); ERG5 (0.888); ERG11 (0.878); ERG13 (0.825); COX5B (0.79); AAC3 (0.786); OLE1 (0.763); HAP1 (0.758); MOT3 (0.724)
Homologues (species, bitscore): CPOX (Homo sapiens, 344.0); Cpox (Mus musculus, 332.0); cpox (Danio rerio, 339.3); cpox (Xenopus tropicalis, 345.1); Coprox (Drosophila melanogaster, 347.8); LIN2 (Arabidopsis thaliana, 335.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:524172-525158:+ | gene-YDR044W_AKU4011 | rna-NM_001180352.1_AKU4011 | cds-NP_010329.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:30046-31032:- | gene-YDR044W_BG1 | rna-NM_001180352.1_BG1 | cds-NP_010329.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:556524-557510:+ | gene-YDR044W_Bruggeman | rna-NM_001180352.1_Bruggeman | cds-NP_010329.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:539522-540508:+ | gene-YDR044W_CAT1 | rna-NM_001180352.1_CAT1 | cds-NP_010329.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:515129-516115:+ | gene-YDR044W_CBS1585 | rna-NM_001180352.1_CBS1585 | cds-NP_010329.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:540299-541285:+ | gene-YDR044W_CBS436 | rna-NM_001180352.1_CBS436 | cds-NP_010329.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:511540-512526:+ | gene-YDR044W_CBS6412 | rna-NM_001180352.1_CBS6412 | cds-NP_010329.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:540208-541194:+ | gene-YDR044W_CBS6413 | rna-NM_001180352.1_CBS6413 | cds-NP_010329.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:545604-546590:+ | gene-YDR044W_CENPK1137D | rna-NM_001180352.1_CENPK1137D | cds-NP_010329.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:525995-526981:+ | gene-YDR044W_EthanolRed | rna-NM_001180352.1_EthanolRed | cds-NP_010329.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:532450-533436:+ | gene-YDR044W_FaliES1 | rna-NM_001180352.1_FaliES1 | cds-NP_010329.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000246.1:21288-22274:- | gene-YDR044W_JAY291 | rna-NM_001180352.1_JAY291 | cds-NP_010329.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:541183-542169:+ | gene-YDR044W_MUCL30387 | rna-NM_001180352.1_MUCL30387 | cds-NP_010329.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:531606-532592:+ | gene-YDR044W_MUCL30388 | rna-NM_001180352.1_MUCL30388 | cds-NP_010329.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:516497-517483:+ | gene-YDR044W_MUCL39482 | rna-NM_001180352.1_MUCL39482 | cds-NP_010329.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:446731-447717:+ | gene-YDR044W_MUCL42920 | rna-NM_001180352.1_MUCL42920 | cds-NP_010329.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:546565-547551:+ | gene-YDR044W_NCIM3186 | rna-NM_001180352.1_NCIM3186 | cds-NP_010329.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:515433-516419:+ | gene-YDR044W_NCYC1407 | rna-NM_001180352.1_NCYC1407 | cds-NP_010329.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:535062-536048:+ | gene-YDR044W_PE2H3 | rna-NM_001180352.1_PE2H3 | cds-NP_010329.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:534367-535353:+ | gene-YDR044W_PE2H4 | rna-NM_001180352.1_PE2H4 | cds-NP_010329.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:546642-547628:+ | gene-YDR044W_S288C | rna-NM_001180352.1_S288C | cds-NP_010329.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000065.1:63834-64820:+ | gene-YDR044W_SA1 | rna-NM_001180352.1_SA1 | cds-NP_010329.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:532176-533162:+ | gene-YDR044W_ThermosaccDry | rna-NM_001180352.1_ThermosaccDry | cds-NP_010329.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:544881-545867:+ | gene-YDR044W_VR1 | rna-NM_001180352.1_VR1 | cds-NP_010329.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:529785-530771:+ | gene-YDR044W_ZTW1 | rna-NM_001180352.1_ZTW1 | cds-NP_010329.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:534175-535161:+ | gene-YDR044W_Sparadoxus | rna-NM_001180352.1_Sparadoxus | cds-NP_010329.1_Sparadoxus | 93.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |