Gene name: HEM12
Reference locus (S288C): YDR047W
Gene biotype: protein_coding
Description: Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
Top 10 interactors (score): HEM3 (0.999); HEM13 (0.999); HEM14 (0.998); HEM4 (0.998); HEM2 (0.991); HEM15 (0.99); MET1 (0.97); HEM1 (0.951); TPI1 (0.891); EMC10 (0.872); DET1 (0.872); YDR053W (0.872); VMS1 (0.872); RPC11 (0.86); CDC34 (0.823); RSM10 (0.809); BAP3 (0.806); HEM25 (0.795); TVP23 (0.787); COQ3 (0.783)
Homologues (species, bitscore): UROD (Homo sapiens, 370.2); Urod (Mus musculus, 364.8); urod (Danio rerio, 403.7); urod (Xenopus tropicalis, 390.2); Urod (Drosophila melanogaster, 327.0); HEME2 (Arabidopsis thaliana, 235.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:529390-530478:+ | gene-YDR047W_AKU4011 | rna-NM_001180355.3_AKU4011 | cds-NP_010332.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:24731-25819:- | gene-YDR047W_BG1 | rna-NM_001180355.3_BG1 | cds-NP_010332.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:561738-562826:+ | gene-YDR047W_Bruggeman | rna-NM_001180355.3_Bruggeman | cds-NP_010332.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:544742-545830:+ | gene-YDR047W_CAT1 | rna-NM_001180355.3_CAT1 | cds-NP_010332.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:520346-521434:+ | gene-YDR047W_CBS1585 | rna-NM_001180355.3_CBS1585 | cds-NP_010332.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:545516-546604:+ | gene-YDR047W_CBS436 | rna-NM_001180355.3_CBS436 | cds-NP_010332.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:516758-517846:+ | gene-YDR047W_CBS6412 | rna-NM_001180355.3_CBS6412 | cds-NP_010332.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:545427-546515:+ | gene-YDR047W_CBS6413 | rna-NM_001180355.3_CBS6413 | cds-NP_010332.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:550816-551904:+ | gene-YDR047W_CENPK1137D | rna-NM_001180355.3_CENPK1137D | cds-NP_010332.3_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:531218-532306:+ | gene-YDR047W_EthanolRed | rna-NM_001180355.3_EthanolRed | cds-NP_010332.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:537657-538745:+ | gene-YDR047W_FaliES1 | rna-NM_001180355.3_FaliES1 | cds-NP_010332.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000246.1:15965-17053:- | gene-YDR047W_JAY291 | rna-NM_001180355.3_JAY291 | cds-NP_010332.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:546402-547490:+ | gene-YDR047W_MUCL30387 | rna-NM_001180355.3_MUCL30387 | cds-NP_010332.3_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:536820-537908:+ | gene-YDR047W_MUCL30388 | rna-NM_001180355.3_MUCL30388 | cds-NP_010332.3_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:521717-522805:+ | gene-YDR047W_MUCL39482 | rna-NM_001180355.3_MUCL39482 | cds-NP_010332.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:451948-453036:+ | gene-YDR047W_MUCL42920 | rna-NM_001180355.3_MUCL42920 | cds-NP_010332.3_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:551783-552871:+ | gene-YDR047W_NCIM3186 | rna-NM_001180355.3_NCIM3186 | cds-NP_010332.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:520652-521740:+ | gene-YDR047W_NCYC1407 | rna-NM_001180355.3_NCYC1407 | cds-NP_010332.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:540282-541370:+ | gene-YDR047W_PE2H3 | rna-NM_001180355.3_PE2H3 | cds-NP_010332.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:539587-540675:+ | gene-YDR047W_PE2H4 | rna-NM_001180355.3_PE2H4 | cds-NP_010332.3_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:551860-552948:+ | gene-YDR047W_S288C | rna-NM_001180355.3_S288C | cds-NP_010332.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:92541-93629:- | gene-YDR047W_SA1 | rna-NM_001180355.3_SA1 | cds-NP_010332.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:537394-538482:+ | gene-YDR047W_ThermosaccDry | rna-NM_001180355.3_ThermosaccDry | cds-NP_010332.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:550098-551186:+ | gene-YDR047W_VR1 | rna-NM_001180355.3_VR1 | cds-NP_010332.3_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:535003-536091:+ | gene-YDR047W_ZTW1 | rna-NM_001180355.3_ZTW1 | cds-NP_010332.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:539389-540477:+ | gene-YDR047W_Sparadoxus | rna-NM_001180355.3_Sparadoxus | cds-NP_010332.3_Sparadoxus | 91.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |