Gene name: HEM1
Reference locus (S288C): YDR232W
Gene biotype: protein_coding
Description: 5-aminolevulinate synthase, mitochondrial; 5-aminolevulinate synthase; catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p; has a pyridoxal phosphate cofactor whose insertion is mediated by Mcx1p; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family
Top 10 interactors (score): HEM2 (0.998); HEM3 (0.992); HEM4 (0.991); HEM15 (0.988); HEM13 (0.976); HEM14 (0.972); SHM1 (0.964); HEM12 (0.951); GLY1 (0.935); GCV2 (0.928); ERG26 (0.926); SHM2 (0.926); ERG7 (0.915); AGX1 (0.913); HEM25 (0.886); ERG1 (0.885); MTM1 (0.812); ERG9 (0.795); MCX1 (0.792); COX10 (0.771)
Homologues (species, bitscore): ALAS2 (Homo sapiens, 391.0); Alas2 (Mus musculus, 393.3); alas2 (Danio rerio, 396.7); alas2 (Xenopus tropicalis, 401.7); Alas (Drosophila melanogaster, 399.8); T25B9.1 (Caenorhabditis elegans, 203.4); BIOF (Arabidopsis thaliana, 176.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:884160-885785:+ | gene-YDR232W_AKU4011 | rna-NM_001180540.1_AKU4011 | cds-NP_010518.1_AKU4011 | 97.9 | 98.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:240025-241671:- | gene-YDR232W_BG1 | rna-NM_001180540.1_BG1 | cds-NP_010518.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:916466-918112:+ | gene-YDR232W_Bruggeman | rna-NM_001180540.1_Bruggeman | cds-NP_010518.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:903754-905400:+ | gene-YDR232W_CAT1 | rna-NM_001180540.1_CAT1 | cds-NP_010518.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:874511-876136:+ | gene-YDR232W_CBS1585 | rna-NM_001180540.1_CBS1585 | cds-NP_010518.1_CBS1585 | 97.9 | 98.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:903514-905160:+ | gene-YDR232W_CBS436 | rna-NM_001180540.1_CBS436 | cds-NP_010518.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:871269-872894:+ | gene-YDR232W_CBS6412 | rna-NM_001180540.1_CBS6412 | cds-NP_010518.1_CBS6412 | 97.9 | 98.7 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:901871-903496:+ | gene-YDR232W_CBS6413 | rna-NM_001180540.1_CBS6413 | cds-NP_010518.1_CBS6413 | 97.9 | 98.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:926250-927902:+ | gene-YDR232W_CENPK1137D | rna-NM_001180540.1_CENPK1137D | cds-NP_010518.1_CENPK1137D | 93.2 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:884843-886519:+ | gene-YDR232W_EthanolRed | rna-NM_001180540.1_EthanolRed | cds-NP_010518.1_EthanolRed | 97.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:893045-894721:+ | gene-YDR232W_FaliES1 | rna-NM_001180540.1_FaliES1 | cds-NP_010518.1_FaliES1 | 97.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000348.1:16875-18521:- | gene-YDR232W_JAY291 | rna-NM_001180540.1_JAY291 | cds-NP_010518.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:902364-904010:+ | gene-YDR232W_MUCL30387 | rna-NM_001180540.1_MUCL30387 | cds-NP_010518.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:890394-892040:+ | gene-YDR232W_MUCL30388 | rna-NM_001180540.1_MUCL30388 | cds-NP_010518.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:875914-877539:+ | gene-YDR232W_MUCL39482 | rna-NM_001180540.1_MUCL39482 | cds-NP_010518.1_MUCL39482 | 97.9 | 98.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:815171-816817:+ | gene-YDR232W_MUCL42920 | rna-NM_001180540.1_MUCL42920 | cds-NP_010518.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:927375-929021:+ | gene-YDR232W_NCIM3186 | rna-NM_001180540.1_NCIM3186 | cds-NP_010518.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:879584-881209:+ | gene-YDR232W_NCYC1407 | rna-NM_001180540.1_NCYC1407 | cds-NP_010518.1_NCYC1407 | 97.9 | 98.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:895810-897462:+ | gene-YDR232W_PE2H3 | rna-NM_001180540.1_PE2H3 | cds-NP_010518.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:901087-902739:+ | gene-YDR232W_PE2H4 | rna-NM_001180540.1_PE2H4 | cds-NP_010518.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:927452-929098:+ | gene-YDR232W_S288C | rna-NM_001180540.1_S288C | cds-NP_010518.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000013.1:133641-135293:+ | gene-YDR232W_SA1 | rna-NM_001180540.1_SA1 | cds-NP_010518.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:891199-892875:+ | gene-YDR232W_ThermosaccDry | rna-NM_001180540.1_ThermosaccDry | cds-NP_010518.1_ThermosaccDry | 97.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:906410-908062:+ | gene-YDR232W_VR1 | rna-NM_001180540.1_VR1 | cds-NP_010518.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000007.1:153910-155556:+ | gene-YDR232W_ZTW1 | rna-NM_001180540.1_ZTW1 | cds-NP_010518.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:896061-897707:+ | gene-YDR232W_Sparadoxus | rna-NM_001180540.1_Sparadoxus | cds-NP_010518.1_Sparadoxus | 91.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |