Gene name: HEL2
Reference locus (S288C): YDR266C
Gene biotype: protein_coding
Description: RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor
Top 10 interactors (score): RKR1 (0.964); SLH1 (0.951); RQC2 (0.925); HBS1 (0.839); RQC1 (0.818); RPS3 (0.772); HUL5 (0.765); UBC4 (0.729); RPS10B (0.719); RPS10A (0.717); MOT2 (0.712); ASC1 (0.708); SKI7 (0.703); DOM34 (0.701); RPS20 (0.693); SMY2 (0.692); SYH1 (0.692); NOC4 (0.69); TSR1 (0.688); CDC48 (0.684)
Homologues (species, bitscore): ZNF598 (Homo sapiens, 136.0); Zfp598 (Mus musculus, 132.1); znf598 (Danio rerio, 136.3); znf598 (Xenopus tropicalis, 132.1); CG11414 (Drosophila melanogaster, 148.3); C52E12.1 (Caenorhabditis elegans, 132.5); AT2G47090 (Arabidopsis thaliana, 162.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:952397-954316:- | gene-YDR266C_AKU4011 | rna-NM_001180574.3_AKU4011 | cds-NP_010552.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:178012-179931:+ | gene-YDR266C_BG1 | rna-NM_001180574.3_BG1 | cds-NP_010552.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:978570-980489:- | gene-YDR266C_Bruggeman | rna-NM_001180574.3_Bruggeman | cds-NP_010552.3_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:966412-968331:- | gene-YDR266C_CAT1 | rna-NM_001180574.3_CAT1 | cds-NP_010552.3_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:946842-948761:- | gene-YDR266C_CBS1585 | rna-NM_001180574.3_CBS1585 | cds-NP_010552.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:964876-966795:- | gene-YDR266C_CBS436 | rna-NM_001180574.3_CBS436 | cds-NP_010552.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:943525-945444:- | gene-YDR266C_CBS6412 | rna-NM_001180574.3_CBS6412 | cds-NP_010552.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:964761-966680:- | gene-YDR266C_CBS6413 | rna-NM_001180574.3_CBS6413 | cds-NP_010552.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:998747-1000666:- | gene-YDR266C_CENPK1137D | rna-NM_001180574.3_CENPK1137D | cds-NP_010552.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:950942-952861:- | gene-YDR266C_EthanolRed | rna-NM_001180574.3_EthanolRed | cds-NP_010552.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:959144-961063:- | gene-YDR266C_FaliES1 | rna-NM_001180574.3_FaliES1 | cds-NP_010552.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000176.1:7401-9320:- | gene-YDR266C_JAY291 | rna-NM_001180574.3_JAY291 | cds-NP_010552.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:964206-966125:- | gene-YDR266C_MUCL30387 | rna-NM_001180574.3_MUCL30387 | cds-NP_010552.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:951915-953834:- | gene-YDR266C_MUCL30388 | rna-NM_001180574.3_MUCL30388 | cds-NP_010552.3_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:938648-940567:- | gene-YDR266C_MUCL39482 | rna-NM_001180574.3_MUCL39482 | cds-NP_010552.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:878644-880563:- | gene-YDR266C_MUCL42920 | rna-NM_001180574.3_MUCL42920 | cds-NP_010552.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1000027-1001946:- | gene-YDR266C_NCIM3186 | rna-NM_001180574.3_NCIM3186 | cds-NP_010552.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:951938-953857:- | gene-YDR266C_NCYC1407 | rna-NM_001180574.3_NCYC1407 | cds-NP_010552.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:962569-964488:- | gene-YDR266C_PE2H3 | rna-NM_001180574.3_PE2H3 | cds-NP_010552.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:967845-969764:- | gene-YDR266C_PE2H4 | rna-NM_001180574.3_PE2H4 | cds-NP_010552.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1000104-1002023:- | gene-YDR266C_S288C | rna-NM_001180574.3_S288C | cds-NP_010552.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000102.1:7726-9645:- | gene-YDR266C_SA1 | rna-NM_001180574.3_SA1 | cds-NP_010552.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:963429-965348:- | gene-YDR266C_ThermosaccDry | rna-NM_001180574.3_ThermosaccDry | cds-NP_010552.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:979025-980944:- | gene-YDR266C_VR1 | rna-NM_001180574.3_VR1 | cds-NP_010552.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:7558-9477:- | gene-YDR266C_ZTW1 | rna-NM_001180574.3_ZTW1 | cds-NP_010552.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:959827-961749:- | gene-YDR266C_Sparadoxus | rna-NM_001180574.3_Sparadoxus | cds-NP_010552.3_Sparadoxus | 89.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |