Gene name: HEL1
Reference locus (S288C): YKR017C
Gene biotype: protein_coding
Description: RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); Belongs to the RBR family
Top 10 interactors (score): ITT1 (0.954); YDR131C (0.813); CTR1 (0.77); MPE1 (0.756); YER135C (0.747); CDC27 (0.746); UBA1 (0.733); HRT1 (0.731); PCI8 (0.696); YEL1 (0.692); YMR310C (0.691); RPS31 (0.678); CDC34 (0.678); DOC1 (0.672); MUK1 (0.67); RPL10 (0.662); UBC5 (0.66); CUL3 (0.655); GTO3 (0.651); SPS4 (0.651)
Homologues (species, bitscore): ARIH1 (Homo sapiens, 242.3); Arih1 (Mus musculus, 242.3); arih1 (Danio rerio, 241.1); arih1 (Xenopus tropicalis, 242.7); ari-1 (Drosophila melanogaster, 228.4); ari-1 (Caenorhabditis elegans, 242.3); ARI7 (Arabidopsis thaliana, 185.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:457364-459019:- | gene-YKR017C_AKU4011 | rna-NM_001179807.3_AKU4011 | cds-NP_012942.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:184483-186138:+ | gene-YKR017C_BG1 | rna-NM_001179807.3_BG1 | cds-NP_012942.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:479037-480692:- | gene-YKR017C_Bruggeman | rna-NM_001179807.3_Bruggeman | cds-NP_012942.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:474778-476433:- | gene-YKR017C_CAT1 | rna-NM_001179807.3_CAT1 | cds-NP_012942.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:470104-471759:- | gene-YKR017C_CBS1585 | rna-NM_001179807.3_CBS1585 | cds-NP_012942.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:468935-470590:- | gene-YKR017C_CBS436 | rna-NM_001179807.3_CBS436 | cds-NP_012942.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:454265-455920:- | gene-YKR017C_CBS6412 | rna-NM_001179807.3_CBS6412 | cds-NP_012942.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:469932-471587:- | gene-YKR017C_CBS6413 | rna-NM_001179807.3_CBS6413 | cds-NP_012942.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:471399-473054:- | gene-YKR017C_CENPK1137D | rna-NM_001179807.3_CENPK1137D | cds-NP_012942.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:467832-469487:- | gene-YKR017C_EthanolRed | rna-NM_001179807.3_EthanolRed | cds-NP_012942.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:470762-472417:- | gene-YKR017C_FaliES1 | rna-NM_001179807.3_FaliES1 | cds-NP_012942.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000077.1:81341-82996:+ | gene-YKR017C_JAY291 | rna-NM_001179807.3_JAY291 | cds-NP_012942.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:478354-480009:- | gene-YKR017C_MUCL30387 | rna-NM_001179807.3_MUCL30387 | cds-NP_012942.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:474044-475699:- | gene-YKR017C_MUCL30388 | rna-NM_001179807.3_MUCL30388 | cds-NP_012942.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:469421-471076:- | gene-YKR017C_MUCL39482 | rna-NM_001179807.3_MUCL39482 | cds-NP_012942.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:475197-476852:- | gene-YKR017C_MUCL42920 | rna-NM_001179807.3_MUCL42920 | cds-NP_012942.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:471683-473338:- | gene-YKR017C_NCIM3186 | rna-NM_001179807.3_NCIM3186 | cds-NP_012942.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:469628-471283:- | gene-YKR017C_NCYC1407 | rna-NM_001179807.3_NCYC1407 | cds-NP_012942.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:494614-496269:- | gene-YKR017C_PE2H3 | rna-NM_001179807.3_PE2H3 | cds-NP_012942.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:479337-480992:- | gene-YKR017C_PE2H4 | rna-NM_001179807.3_PE2H4 | cds-NP_012942.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:471694-473349:- | gene-YKR017C_S288C | rna-NM_001179807.3_S288C | cds-NP_012942.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000078.1:40401-42056:+ | gene-YKR017C_SA1 | rna-NM_001179807.3_SA1 | cds-NP_012942.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:470017-471672:- | gene-YKR017C_ThermosaccDry | rna-NM_001179807.3_ThermosaccDry | cds-NP_012942.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:469634-471289:- | gene-YKR017C_VR1 | rna-NM_001179807.3_VR1 | cds-NP_012942.3_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:468064-469719:- | gene-YKR017C_ZTW1 | rna-NM_001179807.3_ZTW1 | cds-NP_012942.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:493509-495164:- | gene-YKR017C_Sparadoxus | rna-NM_001179807.3_Sparadoxus | cds-NP_012942.3_Sparadoxus | 92.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |