Gene name: HDA1
Reference locus (S288C): YNL021W
Gene biotype: protein_coding
Description: Histone deacetylase HDA1; Putative catalytic subunit of a class II histone deacetylase complex; role in azole resistance via Hsp90p, and in the heat shock response; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; other members of the HDA1 histone deacetylase complex are Hda2p and Hda3p
Top 10 interactors (score): HDA3 (0.999); HDA2 (0.999); RPD3 (0.996); NSP1 (0.991); HOS2 (0.989); HTA1 (0.982); NUP2 (0.981); UBC9 (0.977); HHT2 (0.976); CDC48 (0.973); HTB1 (0.972); NUP170 (0.963); HTA2 (0.962); HTB2 (0.961); SIR2 (0.957); SNT1 (0.956); YRB1 (0.955); SIN3 (0.954); YRB2 (0.943); NUP1 (0.943)
Homologues (species, bitscore): HDAC6 (Homo sapiens, 305.4); Hdac6 (Mus musculus, 313.2); hdac6 (Danio rerio, 318.9); hdac6 (Xenopus tropicalis, 321.6); HDAC6 (Drosophila melanogaster, 273.1); hda-6 (Caenorhabditis elegans, 279.3); HDA15 (Arabidopsis thaliana, 283.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:575686-577806:+ | gene-YNL021W_AKU4011 | rna-NM_001182860.1_AKU4011 | cds-NP_014377.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:462338-464458:- | gene-YNL021W_BG1 | rna-NM_001182860.1_BG1 | cds-NP_014377.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:593106-595226:+ | gene-YNL021W_Bruggeman | rna-NM_001182860.1_Bruggeman | cds-NP_014377.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:628555-630675:+ | gene-YNL021W_CAT1 | rna-NM_001182860.1_CAT1 | cds-NP_014377.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:581370-583490:+ | gene-YNL021W_CBS1585 | rna-NM_001182860.1_CBS1585 | cds-NP_014377.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:643780-645900:+ | gene-YNL021W_CBS436 | rna-NM_001182860.1_CBS436 | cds-NP_014377.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:571203-573323:+ | gene-YNL021W_CBS6412 | rna-NM_001182860.1_CBS6412 | cds-NP_014377.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:572544-574664:+ | gene-YNL021W_CBS6413 | rna-NM_001182860.1_CBS6413 | cds-NP_014377.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:586834-588954:+ | gene-YNL021W_CENPK1137D | rna-NM_001182860.1_CENPK1137D | cds-NP_014377.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:577772-579892:+ | gene-YNL021W_EthanolRed | rna-NM_001182860.1_EthanolRed | cds-NP_014377.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:568796-570916:+ | gene-YNL021W_FaliES1 | rna-NM_001182860.1_FaliES1 | cds-NP_014377.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000387.1:2919-5039:- | gene-YNL021W_JAY291 | rna-NM_001182860.1_JAY291 | cds-NP_014377.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:588988-591108:+ | gene-YNL021W_MUCL30387 | rna-NM_001182860.1_MUCL30387 | cds-NP_014377.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:631782-633902:+ | gene-YNL021W_MUCL30388 | rna-NM_001182860.1_MUCL30388 | cds-NP_014377.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:572965-575085:+ | gene-YNL021W_MUCL39482 | rna-NM_001182860.1_MUCL39482 | cds-NP_014377.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:576523-578643:+ | gene-YNL021W_MUCL42920 | rna-NM_001182860.1_MUCL42920 | cds-NP_014377.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:593196-595316:+ | gene-YNL021W_NCIM3186 | rna-NM_001182860.1_NCIM3186 | cds-NP_014377.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:575170-577290:+ | gene-YNL021W_NCYC1407 | rna-NM_001182860.1_NCYC1407 | cds-NP_014377.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:577693-579813:+ | gene-YNL021W_PE2H3 | rna-NM_001182860.1_PE2H3 | cds-NP_014377.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:579011-581131:+ | gene-YNL021W_PE2H4 | rna-NM_001182860.1_PE2H4 | cds-NP_014377.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:593227-595347:+ | gene-YNL021W_S288C | rna-NM_001182860.1_S288C | cds-NP_014377.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000109.1:19252-21372:+ | gene-YNL021W_SA1 | rna-NM_001182860.1_SA1 | cds-NP_014377.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:569383-571503:+ | gene-YNL021W_ThermosaccDry | rna-NM_001182860.1_ThermosaccDry | cds-NP_014377.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:571248-573368:- | gene-YNL021W_VR1 | rna-NM_001182860.1_VR1 | cds-NP_014377.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:461937-464057:- | gene-YNL021W_ZTW1 | rna-NM_001182860.1_ZTW1 | cds-NP_014377.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:584486-586606:+ | gene-YNL021W_Sparadoxus | rna-NM_001182860.1_Sparadoxus | cds-NP_014377.1_Sparadoxus | 91.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |