Gene name: HCM1
Reference locus (S288C): YCR065W
Gene biotype: protein_coding
Description: Forkhead transcription factor; drives S-phase activation of genes involved in chromosome segregation, spindle dynamics, budding; also activates genes involved in respiration, use of alternative energy sources (like proline), NAD synthesis, oxidative stress resistance; key factor in early adaptation to nutrient deficiency and diauxic shift; suppressor of calmodulin mutants with specific SPB assembly defects; ortholog of C. elegans lifespan regulator PHA-4
Top 10 interactors (score): ABD1 (0.96); CDC28 (0.954); YOX1 (0.935); SWI5 (0.925); UBC9 (0.913); MCM1 (0.901); YHP1 (0.888); HTZ1 (0.836); NDD1 (0.821); CLB2 (0.819); SWI4 (0.812); MBP1 (0.811); GCN5 (0.81); SMT3 (0.806); MAD2 (0.804); ACE2 (0.789); SWI6 (0.776); TUB3 (0.752); CLB5 (0.74); VIK1 (0.728)
Homologues (species, bitscore): FOXJ1 (Homo sapiens, 102.8); Foxk1 (Mus musculus, 102.4); foxq2 (Danio rerio, 105.5); foxj1.2 (Xenopus tropicalis, 109.0); fd102C (Drosophila melanogaster, 103.2); pha-4 (Caenorhabditis elegans, 109.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005297.1:223782-225476:+ | gene-YCR065W_AKU4011 | rna-NM_001178776.1_AKU4011 | cds-NP_009991.2_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000067.1:82498-84192:+ | gene-YCR065W_BG1 | rna-NM_001178776.1_BG1 | cds-NP_009991.2_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005505.1:219742-221436:+ | gene-YCR065W_Bruggeman | rna-NM_001178776.1_Bruggeman | cds-NP_009991.2_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005521.1:231105-232799:+ | gene-YCR065W_CAT1 | rna-NM_001178776.1_CAT1 | cds-NP_009991.2_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005361.1:218561-220255:+ | gene-YCR065W_CBS1585 | rna-NM_001178776.1_CBS1585 | cds-NP_009991.2_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005345.1:230442-232136:+ | gene-YCR065W_CBS436 | rna-NM_001178776.1_CBS436 | cds-NP_009991.2_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005329.1:210301-211995:+ | gene-YCR065W_CBS6412 | rna-NM_001178776.1_CBS6412 | cds-NP_009991.2_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005313.1:224678-226372:+ | gene-YCR065W_CBS6413 | rna-NM_001178776.1_CBS6413 | cds-NP_009991.2_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001524.1:228506-230200:+ | gene-YCR065W_CENPK1137D | rna-NM_001178776.1_CENPK1137D | cds-NP_009991.2_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005473.1:219746-221440:+ | gene-YCR065W_EthanolRed | rna-NM_001178776.1_EthanolRed | cds-NP_009991.2_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005537.1:224910-226604:+ | gene-YCR065W_FaliES1 | rna-NM_001178776.1_FaliES1 | cds-NP_009991.2_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000323.1:62067-63761:- | gene-YCR065W_JAY291 | rna-NM_001178776.1_JAY291 | cds-NP_009991.2_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005409.1:216714-218408:+ | gene-YCR065W_MUCL30387 | rna-NM_001178776.1_MUCL30387 | cds-NP_009991.2_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005441.1:217033-218727:+ | gene-YCR065W_MUCL30388 | rna-NM_001178776.1_MUCL30388 | cds-NP_009991.2_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005281.1:225134-226828:+ | gene-YCR065W_MUCL39482 | rna-NM_001178776.1_MUCL39482 | cds-NP_009991.2_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005425.1:221573-223267:+ | gene-YCR065W_MUCL42920 | rna-NM_001178776.1_MUCL42920 | cds-NP_009991.2_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011812.1:228942-230636:+ | gene-YCR065W_NCIM3186 | rna-NM_001178776.1_NCIM3186 | cds-NP_009991.2_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005265.1:225993-227687:+ | gene-YCR065W_NCYC1407 | rna-NM_001178776.1_NCYC1407 | cds-NP_009991.2_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994142.1:240625-242319:+ | gene-YCR065W_PE2H3 | rna-NM_001178776.1_PE2H3 | cds-NP_009991.2_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999874.1:229176-230870:+ | gene-YCR065W_PE2H4 | rna-NM_001178776.1_PE2H4 | cds-NP_009991.2_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001135.5:229310-231004:+ | gene-YCR065W_S288C | rna-NM_001178776.1_S288C | cds-NP_009991.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000044.1:29203-30897:+ | gene-YCR065W_SA1 | rna-NM_001178776.1_SA1 | cds-NP_009991.2_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005489.1:224895-226589:+ | gene-YCR065W_ThermosaccDry | rna-NM_001178776.1_ThermosaccDry | cds-NP_009991.2_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005457.1:236161-237855:+ | gene-YCR065W_VR1 | rna-NM_001178776.1_VR1 | cds-NP_009991.2_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000004.1:222711-224405:+ | gene-YCR065W_ZTW1 | rna-NM_001178776.1_ZTW1 | cds-NP_009991.2_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047489.1:256901-258598:+ | gene-YCR065W_Sparadoxus | rna-NM_001178776.1_Sparadoxus | cds-NP_009991.2_Sparadoxus | 90.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |