Gene name: HCH1
Reference locus (S288C): YNL281W
Gene biotype: protein_coding
Description: Hsp90 co-chaperone HCH1; Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; Belongs to the AHA1 family
Top 10 interactors (score): AHA1 (0.999); HSP82 (0.995); STI1 (0.992); SBA1 (0.992); HSC82 (0.99); CPR6 (0.97); MBF1 (0.958); CDC37 (0.942); FES1 (0.92); CPR7 (0.908); CNS1 (0.885); SSE1 (0.876); SSE2 (0.84); SIL1 (0.807); PPT1 (0.75); CCT3 (0.743); HSP10 (0.72); TAH1 (0.716); HSP60 (0.703); SGT1 (0.696)
Homologues (species, bitscore): AHSA1 (Homo sapiens, 55.5); Ahsa1 (Mus musculus, 52.8); ahsa1 (Danio rerio, 63.2); ahsa1 (Xenopus tropicalis, 53.1); CG1416 (Drosophila melanogaster, 56.6); ahsa-1 (Caenorhabditis elegans, 50.1); AT3G12050 (Arabidopsis thaliana, 57.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:102274-102735:+ | gene-YNL281W_AKU4011 | rna-NM_001183119.1_AKU4011 | cds-NP_014118.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:6146-6607:+ | gene-YNL281W_BG1 | rna-NM_001183119.1_BG1 | cds-NP_014118.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:112062-112523:+ | gene-YNL281W_Bruggeman | rna-NM_001183119.1_Bruggeman | cds-NP_014118.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:115319-115780:+ | gene-YNL281W_CAT1 | rna-NM_001183119.1_CAT1 | cds-NP_014118.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:102664-103125:+ | gene-YNL281W_CBS1585 | rna-NM_001183119.1_CBS1585 | cds-NP_014118.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:97743-98204:+ | gene-YNL281W_CBS436 | rna-NM_001183119.1_CBS436 | cds-NP_014118.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:99084-99545:+ | gene-YNL281W_CBS6412 | rna-NM_001183119.1_CBS6412 | cds-NP_014118.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:99367-99828:+ | gene-YNL281W_CBS6413 | rna-NM_001183119.1_CBS6413 | cds-NP_014118.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:102299-102760:+ | gene-YNL281W_CENPK1137D | rna-NM_001183119.1_CENPK1137D | cds-NP_014118.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:99891-100352:+ | gene-YNL281W_EthanolRed | rna-NM_001183119.1_EthanolRed | cds-NP_014118.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:94628-95089:+ | gene-YNL281W_FaliES1 | rna-NM_001183119.1_FaliES1 | cds-NP_014118.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000082.1:5852-6313:+ | gene-YNL281W_JAY291 | rna-NM_001183119.1_JAY291 | cds-NP_014118.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:107111-107572:+ | gene-YNL281W_MUCL30387 | rna-NM_001183119.1_MUCL30387 | cds-NP_014118.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:105664-106125:+ | gene-YNL281W_MUCL30388 | rna-NM_001183119.1_MUCL30388 | cds-NP_014118.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:100154-100615:+ | gene-YNL281W_MUCL39482 | rna-NM_001183119.1_MUCL39482 | cds-NP_014118.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:102404-102865:+ | gene-YNL281W_MUCL42920 | rna-NM_001183119.1_MUCL42920 | cds-NP_014118.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:108436-108897:+ | gene-YNL281W_NCIM3186 | rna-NM_001183119.1_NCIM3186 | cds-NP_014118.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:102021-102482:+ | gene-YNL281W_NCYC1407 | rna-NM_001183119.1_NCYC1407 | cds-NP_014118.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:99188-99649:+ | gene-YNL281W_PE2H3 | rna-NM_001183119.1_PE2H3 | cds-NP_014118.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:98576-99037:+ | gene-YNL281W_PE2H4 | rna-NM_001183119.1_PE2H4 | cds-NP_014118.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:108467-108928:+ | gene-YNL281W_S288C | rna-NM_001183119.1_S288C | cds-NP_014118.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000034.1:5919-6380:+ | gene-YNL281W_SA1 | rna-NM_001183119.1_SA1 | cds-NP_014118.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:95485-95946:+ | gene-YNL281W_ThermosaccDry | rna-NM_001183119.1_ThermosaccDry | cds-NP_014118.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:114386-114847:+ | gene-YNL281W_VR1 | rna-NM_001183119.1_VR1 | cds-NP_014118.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:5853-6314:+ | gene-YNL281W_ZTW1 | rna-NM_001183119.1_ZTW1 | cds-NP_014118.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:105752-106213:+ | gene-YNL281W_Sparadoxus | rna-NM_001183119.1_Sparadoxus | cds-NP_014118.1_Sparadoxus | 93.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |