Gene name: HAM1
Reference locus (S288C): YJR069C
Gene biotype: protein_coding
Description: Inosine triphosphate pyrophosphatase; Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA
Top 10 interactors (score): ADE12 (0.996); GUK1 (0.983); APT2 (0.979); DUT1 (0.966); ADE16 (0.961); ADE17 (0.953); YNK1 (0.953); GUA1 (0.944); HPT1 (0.942); YJL055W (0.935); AMD1 (0.933); AAH1 (0.928); CDC19 (0.928); PYK2 (0.928); APT1 (0.927); IMD4 (0.926); IMD3 (0.923); IMD2 (0.92); YND1 (0.914); CYR1 (0.906)
Homologues (species, bitscore): ITPA (Homo sapiens, 139.0); Itpa (Mus musculus, 134.0); itpa (Danio rerio, 146.4); CG8891 (Drosophila melanogaster, 146.7); hap-1 (Caenorhabditis elegans, 139.8); AT4G13720 (Arabidopsis thaliana, 149.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:540332-540925:- | gene-YJR069C_AKU4011 | rna-NM_001181727.1_AKU4011 | cds-NP_012603.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:66694-67287:+ | gene-YJR069C_BG1 | rna-NM_001181727.1_BG1 | cds-NP_012603.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:553848-554441:- | gene-YJR069C_Bruggeman | rna-NM_001181727.1_Bruggeman | cds-NP_012603.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:558155-558748:- | gene-YJR069C_CAT1 | rna-NM_001181727.1_CAT1 | cds-NP_012603.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:552396-552989:- | gene-YJR069C_CBS1585 | rna-NM_001181727.1_CBS1585 | cds-NP_012603.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:570469-571062:- | gene-YJR069C_CBS436 | rna-NM_001181727.1_CBS436 | cds-NP_012603.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:539545-540138:- | gene-YJR069C_CBS6412 | rna-NM_001181727.1_CBS6412 | cds-NP_012603.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:541843-542436:- | gene-YJR069C_CBS6413 | rna-NM_001181727.1_CBS6413 | cds-NP_012603.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:551167-551760:- | gene-YJR069C_CENPK1137D | rna-NM_001181727.1_CENPK1137D | cds-NP_012603.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:544726-545319:- | gene-YJR069C_EthanolRed | rna-NM_001181727.1_EthanolRed | cds-NP_012603.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:556192-556785:- | gene-YJR069C_FaliES1 | rna-NM_001181727.1_FaliES1 | cds-NP_012603.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000054.1:132601-133194:+ | gene-YJR069C_JAY291 | rna-NM_001181727.1_JAY291 | cds-NP_012603.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:554378-554971:- | gene-YJR069C_MUCL30387 | rna-NM_001181727.1_MUCL30387 | cds-NP_012603.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:551671-552264:- | gene-YJR069C_MUCL30388 | rna-NM_001181727.1_MUCL30388 | cds-NP_012603.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:545858-546451:- | gene-YJR069C_MUCL39482 | rna-NM_001181727.1_MUCL39482 | cds-NP_012603.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:550102-550695:- | gene-YJR069C_MUCL42920 | rna-NM_001181727.1_MUCL42920 | cds-NP_012603.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:568785-569378:- | gene-YJR069C_NCIM3186 | rna-NM_001181727.1_NCIM3186 | cds-NP_012603.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:543422-544015:- | gene-YJR069C_NCYC1407 | rna-NM_001181727.1_NCYC1407 | cds-NP_012603.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:561314-561907:- | gene-YJR069C_PE2H3 | rna-NM_001181727.1_PE2H3 | cds-NP_012603.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:555010-555603:- | gene-YJR069C_PE2H4 | rna-NM_001181727.1_PE2H4 | cds-NP_012603.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:568806-569399:- | gene-YJR069C_S288C | rna-NM_001181727.1_S288C | cds-NP_012603.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000038.1:27385-27978:- | gene-YJR069C_SA1 | rna-NM_001181727.1_SA1 | cds-NP_012603.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:550124-550717:- | gene-YJR069C_ThermosaccDry | rna-NM_001181727.1_ThermosaccDry | cds-NP_012603.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:552302-552895:- | gene-YJR069C_VR1 | rna-NM_001181727.1_VR1 | cds-NP_012603.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:529525-530118:- | gene-YJR069C_ZTW1 | rna-NM_001181727.1_ZTW1 | cds-NP_012603.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:562890-563483:- | gene-YJR069C_Sparadoxus | rna-NM_001181727.1_Sparadoxus | cds-NP_012603.1_Sparadoxus | 89.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |