Gene name: GYP5
Reference locus (S288C): YPL249C
Gene biotype: protein_coding
Description: GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication
Top 10 interactors (score): GYL1 (0.999); GYP7 (0.974); RVS167 (0.966); GYP8 (0.939); GYP1 (0.918); YPT1 (0.904); RVS161 (0.886); SEC4 (0.842); YPT6 (0.838); YPT11 (0.794); GYP6 (0.751); ARF3 (0.682); SRL2 (0.674); SEC22 (0.649); YPT53 (0.648); RPL25 (0.646); YPT7 (0.615); YPT31 (0.606); SEC15 (0.605); YPT52 (0.597)
Homologues (species, bitscore): RABGAP1 (Homo sapiens, 197.2); Evi5 (Mus musculus, 184.9); RABGAP1 (Danio rerio, 196.8); rabgap1 (Xenopus tropicalis, 189.9); GAPcenA (Drosophila melanogaster, 183.7); tbc-11 (Caenorhabditis elegans, 174.9); AT3G02460 (Arabidopsis thaliana, 156.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:54410-57103:- | gene-YPL249C_AKU4011 | rna-NM_001184063.1_AKU4011 | cds-NP_015075.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000184.1:18040-20724:+ | gene-YPL249C_BG1 | rna-NM_001184063.1_BG1 | cds-NP_015075.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:78298-80991:- | gene-YPL249C_Bruggeman | rna-NM_001184063.1_Bruggeman | cds-NP_015075.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:76416-79100:- | gene-YPL249C_CAT1 | rna-NM_001184063.1_CAT1 | cds-NP_015075.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:58723-61416:- | gene-YPL249C_CBS1585 | rna-NM_001184063.1_CBS1585 | cds-NP_015075.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:73152-75836:- | gene-YPL249C_CBS436 | rna-NM_001184063.1_CBS436 | cds-NP_015075.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:63887-66580:- | gene-YPL249C_CBS6412 | rna-NM_001184063.1_CBS6412 | cds-NP_015075.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:54873-57566:- | gene-YPL249C_CBS6413 | rna-NM_001184063.1_CBS6413 | cds-NP_015075.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:76604-79288:- | gene-YPL249C_CENPK1137D | rna-NM_001184063.1_CENPK1137D | cds-NP_015075.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:53827-56520:- | gene-YPL249C_EthanolRed | rna-NM_001184063.1_EthanolRed | cds-NP_015075.1_EthanolRed | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:60634-63327:- | gene-YPL249C_FaliES1 | rna-NM_001184063.1_FaliES1 | cds-NP_015075.1_FaliES1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000264.1:17441-20125:+ | gene-YPL249C_JAY291 | rna-NM_001184063.1_JAY291 | cds-NP_015075.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:71463-74147:- | gene-YPL249C_MUCL30387 | rna-NM_001184063.1_MUCL30387 | cds-NP_015075.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:69905-72589:- | gene-YPL249C_MUCL30388 | rna-NM_001184063.1_MUCL30388 | cds-NP_015075.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:51853-54546:- | gene-YPL249C_MUCL39482 | rna-NM_001184063.1_MUCL39482 | cds-NP_015075.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:70734-73418:- | gene-YPL249C_MUCL42920 | rna-NM_001184063.1_MUCL42920 | cds-NP_015075.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:76652-79336:- | gene-YPL249C_NCIM3186 | rna-NM_001184063.1_NCIM3186 | cds-NP_015075.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:58300-60993:- | gene-YPL249C_NCYC1407 | rna-NM_001184063.1_NCYC1407 | cds-NP_015075.1_NCYC1407 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:66032-68716:- | gene-YPL249C_PE2H3 | rna-NM_001184063.1_PE2H3 | cds-NP_015075.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:65675-68359:- | gene-YPL249C_PE2H4 | rna-NM_001184063.1_PE2H4 | cds-NP_015075.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:76669-79353:- | gene-YPL249C_S288C | rna-NM_001184063.1_S288C | cds-NP_015075.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000056.1:18549-21233:- | gene-YPL249C_SA1 | rna-NM_001184063.1_SA1 | cds-NP_015075.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:60635-63328:- | gene-YPL249C_ThermosaccDry | rna-NM_001184063.1_ThermosaccDry | cds-NP_015075.1_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:300501-303185:- | gene-YPL249C_VR1 | rna-NM_001184063.1_VR1 | cds-NP_015075.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:60179-62873:- | gene-YPL249C_ZTW1 | rna-NM_001184063.1_ZTW1 | cds-NP_015075.1_ZTW1 | 99.1 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:61679-64375:- | gene-YPL249C_Sparadoxus | rna-NM_001184063.1_Sparadoxus | cds-NP_015075.1_Sparadoxus | 86.7 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |