Gene name: GUA1
Reference locus (S288C): YMR217W
Gene biotype: protein_coding
Description: GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA
Top 10 interactors (score): IMD4 (0.999); IMD3 (0.999); URA7 (0.998); UBP15 (0.997); IMD2 (0.995); RPA135 (0.992); BRX1 (0.992); NOP56 (0.991); ERB1 (0.991); YTM1 (0.989); NOP1 (0.989); TEF4 (0.988); NMD3 (0.988); AAH1 (0.987); UBP2 (0.987); ADE13 (0.987); NOP7 (0.984); GUK1 (0.984); HIS7 (0.984); HPT1 (0.983)
Homologues (species, bitscore): GMPS (Homo sapiens, 304.7); Gmps (Mus musculus, 306.2); gmps (Danio rerio, 310.1); GMPS (Xenopus tropicalis, 292.0); bur (Drosophila melanogaster, 284.3); M106.4 (Caenorhabditis elegans, 293.9); AT1G63660 (Arabidopsis thaliana, 521.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:741712-743289:+ | gene-YMR217W_AKU4011 | rna-NM_001182724.1_AKU4011 | cds-NP_013944.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:211319-212896:- | gene-YMR217W_BG1 | rna-NM_001182724.1_BG1 | cds-NP_013944.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:685926-687503:+ | gene-YMR217W_Bruggeman | rna-NM_001182724.1_Bruggeman | cds-NP_013944.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:689183-690760:+ | gene-YMR217W_CAT1 | rna-NM_001182724.1_CAT1 | cds-NP_013944.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:673973-675550:+ | gene-YMR217W_CBS1585 | rna-NM_001182724.1_CBS1585 | cds-NP_013944.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:678224-679801:+ | gene-YMR217W_CBS436 | rna-NM_001182724.1_CBS436 | cds-NP_013944.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:785534-787111:+ | gene-YMR217W_CBS6412 | rna-NM_001182724.1_CBS6412 | cds-NP_013944.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:673125-674702:+ | gene-YMR217W_CBS6413 | rna-NM_001182724.1_CBS6413 | cds-NP_013944.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:696511-698088:+ | gene-YMR217W_CENPK1137D | rna-NM_001182724.1_CENPK1137D | cds-NP_013944.1_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:734179-735756:+ | gene-YMR217W_EthanolRed | rna-NM_001182724.1_EthanolRed | cds-NP_013944.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:679831-681408:+ | gene-YMR217W_FaliES1 | rna-NM_001182724.1_FaliES1 | cds-NP_013944.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000141.1:104628-106205:- | gene-YMR217W_JAY291 | rna-NM_001182724.1_JAY291 | cds-NP_013944.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:679473-681050:+ | gene-YMR217W_MUCL30387 | rna-NM_001182724.1_MUCL30387 | cds-NP_013944.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:686252-687829:+ | gene-YMR217W_MUCL30388 | rna-NM_001182724.1_MUCL30388 | cds-NP_013944.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:675043-676620:+ | gene-YMR217W_MUCL39482 | rna-NM_001182724.1_MUCL39482 | cds-NP_013944.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:682366-683943:+ | gene-YMR217W_MUCL42920 | rna-NM_001182724.1_MUCL42920 | cds-NP_013944.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:701744-703321:+ | gene-YMR217W_NCIM3186 | rna-NM_001182724.1_NCIM3186 | cds-NP_013944.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:674699-676276:+ | gene-YMR217W_NCYC1407 | rna-NM_001182724.1_NCYC1407 | cds-NP_013944.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:684544-686121:+ | gene-YMR217W_PE2H3 | rna-NM_001182724.1_PE2H3 | cds-NP_013944.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:685559-687136:+ | gene-YMR217W_PE2H4 | rna-NM_001182724.1_PE2H4 | cds-NP_013944.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:701790-703367:+ | gene-YMR217W_S288C | rna-NM_001182724.1_S288C | cds-NP_013944.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:104742-106319:- | gene-YMR217W_SA1 | rna-NM_001182724.1_SA1 | cds-NP_013944.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:676002-677579:+ | gene-YMR217W_ThermosaccDry | rna-NM_001182724.1_ThermosaccDry | cds-NP_013944.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:689071-690648:+ | gene-YMR217W_VR1 | rna-NM_001182724.1_VR1 | cds-NP_013944.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000028.1:91708-93285:+ | gene-YMR217W_ZTW1 | rna-NM_001182724.1_ZTW1 | cds-NP_013944.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:693820-695397:+ | gene-YMR217W_Sparadoxus | rna-NM_001182724.1_Sparadoxus | cds-NP_013944.1_Sparadoxus | 94.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |