Gene name: GSH1
Reference locus (S288C): YJL101C
Gene biotype: protein_coding
Description: Glutamate--cysteine ligase; Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress; Belongs to the glutamate--cysteine ligase type 3 family
Top 10 interactors (score): GSH2 (0.999); GLR1 (0.992); ECM38 (0.986); CYS3 (0.986); SOD2 (0.976); STR3 (0.972); CTT1 (0.969); MET17 (0.969); CTA1 (0.963); CYS4 (0.944); TRR1 (0.943); MCY1 (0.941); TRX2 (0.936); YAP1 (0.916); TRX1 (0.914); OXP1 (0.914); DUG1 (0.914); SOD1 (0.909); GLN1 (0.903); BAT2 (0.903)
Homologues (species, bitscore): GCLC (Homo sapiens, 489.2); Gclc (Mus musculus, 488.8); gclc (Danio rerio, 476.5); gclc (Xenopus tropicalis, 478.4); Gclc (Drosophila melanogaster, 407.1); gcs-1 (Caenorhabditis elegans, 418.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:217060-219096:- | gene-YJL101C_AKU4011 | rna-NM_001181534.1_AKU4011 | cds-NP_012434.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:395358-397394:+ | gene-YJL101C_BG1 | rna-NM_001181534.1_BG1 | cds-NP_012434.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:228485-230521:- | gene-YJL101C_Bruggeman | rna-NM_001181534.1_Bruggeman | cds-NP_012434.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:233400-235436:- | gene-YJL101C_CAT1 | rna-NM_001181534.1_CAT1 | cds-NP_012434.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:228721-230757:- | gene-YJL101C_CBS1585 | rna-NM_001181534.1_CBS1585 | cds-NP_012434.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:246809-248845:- | gene-YJL101C_CBS436 | rna-NM_001181534.1_CBS436 | cds-NP_012434.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:217818-219854:- | gene-YJL101C_CBS6412 | rna-NM_001181534.1_CBS6412 | cds-NP_012434.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:219173-221209:- | gene-YJL101C_CBS6413 | rna-NM_001181534.1_CBS6413 | cds-NP_012434.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:216774-218810:- | gene-YJL101C_CENPK1137D | rna-NM_001181534.1_CENPK1137D | cds-NP_012434.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:220908-222944:- | gene-YJL101C_EthanolRed | rna-NM_001181534.1_EthanolRed | cds-NP_012434.1_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:232485-234521:- | gene-YJL101C_FaliES1 | rna-NM_001181534.1_FaliES1 | cds-NP_012434.1_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000138.1:30101-32137:- | gene-YJL101C_JAY291 | rna-NM_001181534.1_JAY291 | cds-NP_012434.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:230752-232788:- | gene-YJL101C_MUCL30387 | rna-NM_001181534.1_MUCL30387 | cds-NP_012434.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:226831-228867:- | gene-YJL101C_MUCL30388 | rna-NM_001181534.1_MUCL30388 | cds-NP_012434.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:221478-223514:- | gene-YJL101C_MUCL39482 | rna-NM_001181534.1_MUCL39482 | cds-NP_012434.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:227659-229695:- | gene-YJL101C_MUCL42920 | rna-NM_001181534.1_MUCL42920 | cds-NP_012434.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:234299-236335:- | gene-YJL101C_NCIM3186 | rna-NM_001181534.1_NCIM3186 | cds-NP_012434.1_NCIM3186 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:220167-222203:- | gene-YJL101C_NCYC1407 | rna-NM_001181534.1_NCYC1407 | cds-NP_012434.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:232526-234562:- | gene-YJL101C_PE2H3 | rna-NM_001181534.1_PE2H3 | cds-NP_012434.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:232170-234206:- | gene-YJL101C_PE2H4 | rna-NM_001181534.1_PE2H4 | cds-NP_012434.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:234320-236356:- | gene-YJL101C_S288C | rna-NM_001181534.1_S288C | cds-NP_012434.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000003.1:30044-32080:- | gene-YJL101C_SA1 | rna-NM_001181534.1_SA1 | cds-NP_012434.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:225894-227930:- | gene-YJL101C_ThermosaccDry | rna-NM_001181534.1_ThermosaccDry | cds-NP_012434.1_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:226305-228341:- | gene-YJL101C_VR1 | rna-NM_001181534.1_VR1 | cds-NP_012434.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:207253-209289:- | gene-YJL101C_ZTW1 | rna-NM_001181534.1_ZTW1 | cds-NP_012434.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:231326-233362:- | gene-YJL101C_Sparadoxus | rna-NM_001181534.1_Sparadoxus | cds-NP_012434.1_Sparadoxus | 91.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |