Gene name: GRX4
Reference locus (S288C): YER174C
Gene biotype: protein_coding
Description: Monothiol glutaredoxin-4; Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; with Grx3p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; mutant has increased aneuploidy tolerance; transcription regulated by Yap5p; GRX4 has a paralog, GRX3, that arose from the whole genome duplication
Top 10 interactors (score): BOL2 (0.999); DRE2 (0.996); BOL1 (0.98); BUD32 (0.979); AFT1 (0.974); BOL3 (0.939); FRA1 (0.915); NAR1 (0.873); ISA1 (0.859); GRX2 (0.855); GRX6 (0.815); GRX7 (0.815); GRX3 (0.808); ISU1 (0.799); TYW1 (0.782); ATM1 (0.756); AFT2 (0.745); KAE1 (0.743); CCC1 (0.733); NFU1 (0.733)
Homologues (species, bitscore): GLRX3 (Homo sapiens, 177.9); Glrx3 (Mus musculus, 175.6); glrx3 (Danio rerio, 178.3); glrx3 (Xenopus tropicalis, 176.0); CG6523 (Drosophila melanogaster, 163.3); glrx-3 (Caenorhabditis elegans, 167.9); GRXS17 (Arabidopsis thaliana, 181.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:519955-520689:- | gene-YER174C_AKU4011 | rna-NM_001179064.3_AKU4011 | cds-NP_011101.3_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000176.1:12677-13411:+ | gene-YER174C_BG1 | rna-NM_001179064.3_BG1 | cds-NP_011101.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:532698-533432:- | gene-YER174C_Bruggeman | rna-NM_001179064.3_Bruggeman | cds-NP_011101.3_Bruggeman | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:519286-520020:- | gene-YER174C_CAT1 | rna-NM_001179064.3_CAT1 | cds-NP_011101.3_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:519762-520496:- | gene-YER174C_CBS1585 | rna-NM_001179064.3_CBS1585 | cds-NP_011101.3_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:529655-530389:- | gene-YER174C_CBS436 | rna-NM_001179064.3_CBS436 | cds-NP_011101.3_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:517739-518473:- | gene-YER174C_CBS6412 | rna-NM_001179064.3_CBS6412 | cds-NP_011101.3_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:526308-527042:- | gene-YER174C_CBS6413 | rna-NM_001179064.3_CBS6413 | cds-NP_011101.3_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:536203-536937:- | gene-YER174C_CENPK1137D | rna-NM_001179064.3_CENPK1137D | cds-NP_011101.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:525930-526664:- | gene-YER174C_EthanolRed | rna-NM_001179064.3_EthanolRed | cds-NP_011101.3_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:526866-527600:- | gene-YER174C_FaliES1 | rna-NM_001179064.3_FaliES1 | cds-NP_011101.3_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000169.1:12306-13040:+ | gene-YER174C_JAY291 | rna-NM_001179064.3_JAY291 | cds-NP_011101.3_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:520011-520745:- | gene-YER174C_MUCL30387 | rna-NM_001179064.3_MUCL30387 | cds-NP_011101.3_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:522927-523661:- | gene-YER174C_MUCL30388 | rna-NM_001179064.3_MUCL30388 | cds-NP_011101.3_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:515720-516454:- | gene-YER174C_MUCL39482 | rna-NM_001179064.3_MUCL39482 | cds-NP_011101.3_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:530243-530977:- | gene-YER174C_MUCL42920 | rna-NM_001179064.3_MUCL42920 | cds-NP_011101.3_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:538433-539167:- | gene-YER174C_NCIM3186 | rna-NM_001179064.3_NCIM3186 | cds-NP_011101.3_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:525175-525909:- | gene-YER174C_NCYC1407 | rna-NM_001179064.3_NCYC1407 | cds-NP_011101.3_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:541109-541843:- | gene-YER174C_PE2H3 | rna-NM_001179064.3_PE2H3 | cds-NP_011101.3_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:531049-531783:- | gene-YER174C_PE2H4 | rna-NM_001179064.3_PE2H4 | cds-NP_011101.3_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:538434-539168:- | gene-YER174C_S288C | rna-NM_001179064.3_S288C | cds-NP_011101.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000030.1:90586-91320:- | gene-YER174C_SA1 | rna-NM_001179064.3_SA1 | cds-NP_011101.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:527666-528400:- | gene-YER174C_ThermosaccDry | rna-NM_001179064.3_ThermosaccDry | cds-NP_011101.3_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:520952-521686:- | gene-YER174C_VR1 | rna-NM_001179064.3_VR1 | cds-NP_011101.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000011.1:40512-41246:- | gene-YER174C_ZTW1 | rna-NM_001179064.3_ZTW1 | cds-NP_011101.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:528896-529630:- | gene-YER174C_Sparadoxus | rna-NM_001179064.3_Sparadoxus | cds-NP_011101.3_Sparadoxus | 90.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |