Gene name: GRS1
Reference locus (S288C): YBR121C
Gene biotype: protein_coding
Description: Glycine--tRNA ligase 1, mitochondrial; Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication; human homolog GARS implicated in Charcot-Marie-Tooth disease, can complement yeast null mutant
Top 10 interactors (score): ILS1 (0.996); SES1 (0.994); ALA1 (0.993); VAS1 (0.987); THS1 (0.987); TYS1 (0.976); GUS1 (0.975); HTS1 (0.974); KRS1 (0.971); DED81 (0.957); CDC60 (0.947); TEF4 (0.937); YDR341C (0.937); GLN4 (0.935); MES1 (0.931); MSY1 (0.928); MSK1 (0.922); YHR020W (0.918); CAM1 (0.907); MST1 (0.895)
Homologues (species, bitscore): GARS (Homo sapiens, 619.0); Gars (Mus musculus, 624.4); gars (Danio rerio, 626.7); gars (Xenopus tropicalis, 611.7); Aats-gly (Drosophila melanogaster, 638.6); gars-1 (Caenorhabditis elegans, 613.2); AT1G29880 (Arabidopsis thaliana, 588.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:464246-466249:- | gene-YBR121C_AKU4011 | rna-NM_001178469.2_AKU4011 | cds-NP_009679.2_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:454786-456789:- | gene-YBR121C_BG1 | rna-NM_001178469.2_BG1 | cds-NP_009679.2_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:466022-468025:- | gene-YBR121C_Bruggeman | rna-NM_001178469.2_Bruggeman | cds-NP_009679.2_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:469190-471193:- | gene-YBR121C_CAT1 | rna-NM_001178469.2_CAT1 | cds-NP_009679.2_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:456030-458033:- | gene-YBR121C_CBS1585 | rna-NM_001178469.2_CBS1585 | cds-NP_009679.2_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:464101-466104:- | gene-YBR121C_CBS436 | rna-NM_001178469.2_CBS436 | cds-NP_009679.2_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:553893-555896:- | gene-YBR121C_CBS6412 | rna-NM_001178469.2_CBS6412 | cds-NP_009679.2_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:461658-463661:- | gene-YBR121C_CBS6413 | rna-NM_001178469.2_CBS6413 | cds-NP_009679.2_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:475136-477139:- | gene-YBR121C_CENPK1137D | rna-NM_001178469.2_CENPK1137D | cds-NP_009679.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:590268-592271:- | gene-YBR121C_EthanolRed | rna-NM_001178469.2_EthanolRed | cds-NP_009679.2_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:480285-482288:- | gene-YBR121C_FaliES1 | rna-NM_001178469.2_FaliES1 | cds-NP_009679.2_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000444.1:3692-5695:- | gene-YBR121C_JAY291 | rna-NM_001178469.2_JAY291 | cds-NP_009679.2_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:468930-470933:- | gene-YBR121C_MUCL30387 | rna-NM_001178469.2_MUCL30387 | cds-NP_009679.2_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:467282-469285:- | gene-YBR121C_MUCL30388 | rna-NM_001178469.2_MUCL30388 | cds-NP_009679.2_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:454423-456426:- | gene-YBR121C_MUCL39482 | rna-NM_001178469.2_MUCL39482 | cds-NP_009679.2_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:464337-466340:- | gene-YBR121C_MUCL42920 | rna-NM_001178469.2_MUCL42920 | cds-NP_009679.2_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:481161-483164:- | gene-YBR121C_NCIM3186 | rna-NM_001178469.2_NCIM3186 | cds-NP_009679.2_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:456951-458954:- | gene-YBR121C_NCYC1407 | rna-NM_001178469.2_NCYC1407 | cds-NP_009679.2_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:469530-471533:- | gene-YBR121C_PE2H3 | rna-NM_001178469.2_PE2H3 | cds-NP_009679.2_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:467206-469209:- | gene-YBR121C_PE2H4 | rna-NM_001178469.2_PE2H4 | cds-NP_009679.2_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:481364-483367:- | gene-YBR121C_S288C | rna-NM_001178469.2_S288C | cds-NP_009679.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000032.1:2463-4466:- | gene-YBR121C_SA1 | rna-NM_001178469.2_SA1 | cds-NP_009679.2_SA1 | 99.3 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:479292-481295:- | gene-YBR121C_ThermosaccDry | rna-NM_001178469.2_ThermosaccDry | cds-NP_009679.2_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:460784-462787:- | gene-YBR121C_VR1 | rna-NM_001178469.2_VR1 | cds-NP_009679.2_VR1 | 99.3 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:454439-456442:- | gene-YBR121C_ZTW1 | rna-NM_001178469.2_ZTW1 | cds-NP_009679.2_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:491648-493645:- | gene-YBR121C_Sparadoxus | rna-NM_001178469.2_Sparadoxus | cds-NP_009679.2_Sparadoxus | 93.1 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |