Gene name: GRE3
Reference locus (S288C): YHR104W
Gene biotype: protein_coding
Description: Trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (nadp(+)); Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): XYL2 (0.998); SOR1 (0.993); SOR2 (0.987); XKS1 (0.983); PGM2 (0.963); TAL1 (0.963); GLO1 (0.962); HSP104 (0.95); DCS1 (0.934); SOL4 (0.931); PNC1 (0.93); RTC3 (0.928); GLK1 (0.927); TFS1 (0.926); TKL1 (0.923); GAD1 (0.922); TSL1 (0.922); MSC1 (0.903); RPE1 (0.902); PRX1 (0.901)
Homologues (species, bitscore): AKR1A1 (Homo sapiens, 226.9); Akr1a1 (Mus musculus, 227.3); akr1b1 (Danio rerio, 234.2); akr1a1 (Xenopus tropicalis, 222.6); CG6083 (Drosophila melanogaster, 214.2); Y39G8B.1 (Caenorhabditis elegans, 196.8); AT2G21250 (Arabidopsis thaliana, 208.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:310323-311306:+ | gene-YHR104W_AKU4011 | rna-NM_001179234.1_AKU4011 | cds-NP_011972.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000141.1:206597-207580:- | gene-YHR104W_BG1 | rna-NM_001179234.1_BG1 | cds-NP_011972.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:317619-318602:+ | gene-YHR104W_Bruggeman | rna-NM_001179234.1_Bruggeman | cds-NP_011972.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:312764-313747:+ | gene-YHR104W_CAT1 | rna-NM_001179234.1_CAT1 | cds-NP_011972.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:309350-310333:+ | gene-YHR104W_CBS1585 | rna-NM_001179234.1_CBS1585 | cds-NP_011972.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:306707-307690:+ | gene-YHR104W_CBS436 | rna-NM_001179234.1_CBS436 | cds-NP_011972.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:311158-312141:+ | gene-YHR104W_CBS6412 | rna-NM_001179234.1_CBS6412 | cds-NP_011972.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:310374-311357:+ | gene-YHR104W_CBS6413 | rna-NM_001179234.1_CBS6413 | cds-NP_011972.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:316580-317563:+ | gene-YHR104W_CENPK1137D | rna-NM_001179234.1_CENPK1137D | cds-NP_011972.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:369234-370217:+ | gene-YHR104W_EthanolRed | rna-NM_001179234.1_EthanolRed | cds-NP_011972.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:310722-311705:+ | gene-YHR104W_FaliES1 | rna-NM_001179234.1_FaliES1 | cds-NP_011972.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000045.1:31304-32287:+ | gene-YHR104W_JAY291 | rna-NM_001179234.1_JAY291 | cds-NP_011972.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:317344-318327:+ | gene-YHR104W_MUCL30387 | rna-NM_001179234.1_MUCL30387 | cds-NP_011972.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:316997-317980:+ | gene-YHR104W_MUCL30388 | rna-NM_001179234.1_MUCL30388 | cds-NP_011972.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:309687-310670:+ | gene-YHR104W_MUCL39482 | rna-NM_001179234.1_MUCL39482 | cds-NP_011972.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:315939-316922:+ | gene-YHR104W_MUCL42920 | rna-NM_001179234.1_MUCL42920 | cds-NP_011972.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:323291-324274:+ | gene-YHR104W_NCIM3186 | rna-NM_001179234.1_NCIM3186 | cds-NP_011972.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:311896-312879:+ | gene-YHR104W_NCYC1407 | rna-NM_001179234.1_NCYC1407 | cds-NP_011972.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:311340-312323:+ | gene-YHR104W_PE2H3 | rna-NM_001179234.1_PE2H3 | cds-NP_011972.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:318767-319750:+ | gene-YHR104W_PE2H4 | rna-NM_001179234.1_PE2H4 | cds-NP_011972.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:323409-324392:+ | gene-YHR104W_S288C | rna-NM_001179234.1_S288C | cds-NP_011972.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000014.1:34584-35567:- | gene-YHR104W_SA1 | rna-NM_001179234.1_SA1 | cds-NP_011972.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:311805-312788:+ | gene-YHR104W_ThermosaccDry | rna-NM_001179234.1_ThermosaccDry | cds-NP_011972.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:319428-320411:+ | gene-YHR104W_VR1 | rna-NM_001179234.1_VR1 | cds-NP_011972.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:302839-303821:+ | gene-YHR104W_ZTW1 | rna-NM_001179234.1_ZTW1 | cds-NP_011972.1_ZTW1 | 99.4 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:308487-309470:+ | gene-YHR104W_Sparadoxus | rna-NM_001179234.1_Sparadoxus | cds-NP_011972.1_Sparadoxus | 91.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |