Gene name: GRE2
Reference locus (S288C): YOL151W
Gene biotype: protein_coding
Description: 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase
Top 10 interactors (score): YML131W (0.983); HSP31 (0.963); GLO1 (0.92); HSP32 (0.918); HSP33 (0.903); SNO4 (0.903); YNL134C (0.829); TRP5 (0.82); ILV1 (0.807); CHA1 (0.805); DSD1 (0.8); CTT1 (0.77); CTH1 (0.753); AHP1 (0.725); ICT1 (0.717); OYE3 (0.716); GRE1 (0.714); STL1 (0.713); YDL114W (0.7); SKO1 (0.698)
Homologues (species, bitscore): Hsd3b1 (Mus musculus, 50.8); F13D11.4 (Caenorhabditis elegans, 134.8); AT5G19440 (Arabidopsis thaliana, 119.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:32369-33397:+ | gene-YOL151W_AKU4011 | rna-NM_001183405.1_AKU4011 | cds-NP_014490.1_AKU4011 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000084.1:995-2023:- | gene-YOL151W_BG1 | rna-NM_001183405.1_BG1 | cds-NP_014490.1_BG1 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:33633-34661:+ | gene-YOL151W_Bruggeman | rna-NM_001183405.1_Bruggeman | cds-NP_014490.1_Bruggeman | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:32326-33354:+ | gene-YOL151W_CAT1 | rna-NM_001183405.1_CAT1 | cds-NP_014490.1_CAT1 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:26836-27864:+ | gene-YOL151W_CBS1585 | rna-NM_001183405.1_CBS1585 | cds-NP_014490.1_CBS1585 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:32688-33716:+ | gene-YOL151W_CBS436 | rna-NM_001183405.1_CBS436 | cds-NP_014490.1_CBS436 | 98.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:26738-27766:+ | gene-YOL151W_CBS6412 | rna-NM_001183405.1_CBS6412 | cds-NP_014490.1_CBS6412 | 98.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:33184-34212:+ | gene-YOL151W_CBS6413 | rna-NM_001183405.1_CBS6413 | cds-NP_014490.1_CBS6413 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:43613-44641:+ | gene-YOL151W_CENPK1137D | rna-NM_001183405.1_CENPK1137D | cds-NP_014490.1_CENPK1137D | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:30810-31838:+ | gene-YOL151W_EthanolRed | rna-NM_001183405.1_EthanolRed | cds-NP_014490.1_EthanolRed | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:32635-33663:+ | gene-YOL151W_FaliES1 | rna-NM_001183405.1_FaliES1 | cds-NP_014490.1_FaliES1 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000105.1:12441-13469:+ | gene-YOL151W_JAY291 | rna-NM_001183405.1_JAY291 | cds-NP_014490.1_JAY291 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:38256-39284:+ | gene-YOL151W_MUCL30387 | rna-NM_001183405.1_MUCL30387 | cds-NP_014490.1_MUCL30387 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:41263-42291:+ | gene-YOL151W_MUCL30388 | rna-NM_001183405.1_MUCL30388 | cds-NP_014490.1_MUCL30388 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:34764-35792:+ | gene-YOL151W_MUCL39482 | rna-NM_001183405.1_MUCL39482 | cds-NP_014490.1_MUCL39482 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:50689-51717:+ | gene-YOL151W_MUCL42920 | rna-NM_001183405.1_MUCL42920 | cds-NP_014490.1_MUCL42920 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:43583-44611:+ | gene-YOL151W_NCIM3186 | rna-NM_001183405.1_NCIM3186 | cds-NP_014490.1_NCIM3186 | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:40847-41875:+ | gene-YOL151W_NCYC1407 | rna-NM_001183405.1_NCYC1407 | cds-NP_014490.1_NCYC1407 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:19237-20265:+ | gene-YOL151W_PE2H3 | rna-NM_001183405.1_PE2H3 | cds-NP_014490.1_PE2H3 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:36185-37213:+ | gene-YOL151W_PE2H4 | rna-NM_001183405.1_PE2H4 | cds-NP_014490.1_PE2H4 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:43694-44722:+ | gene-YOL151W_S288C | rna-NM_001183405.1_S288C | cds-NP_014490.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:17092-18120:+ | gene-YOL151W_SA1 | rna-NM_001183405.1_SA1 | cds-NP_014490.1_SA1 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:31776-32804:+ | gene-YOL151W_ThermosaccDry | rna-NM_001183405.1_ThermosaccDry | cds-NP_014490.1_ThermosaccDry | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:32457-33485:+ | gene-YOL151W_VR1 | rna-NM_001183405.1_VR1 | cds-NP_014490.1_VR1 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:31566-32594:+ | gene-YOL151W_ZTW1 | rna-NM_001183405.1_ZTW1 | cds-NP_014490.1_ZTW1 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:34078-35106:+ | gene-YOL151W_Sparadoxus | rna-NM_001183405.1_Sparadoxus | cds-NP_014490.1_Sparadoxus | 91.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |