Gene name: GRC3
Reference locus (S288C): YLL035W
Gene biotype: protein_coding
Description: Polynucleotide 5'-hydroxyl-kinase GRC3; Polynucleotide kinase present on rDNA; required for efficient transcription termination by RNA polymerase I; functions with Las1p in a conserved mechanism to modulate rRNA processing and ribosome biogenesis; required for cell growth; mRNA is cell-cycle regulated; Belongs to the Clp1 family. NOL9/GRC3 subfamily
Top 10 interactors (score): LAS1 (0.999); IPI3 (0.997); IPI1 (0.958); RAT1 (0.958); NUG1 (0.95); ULP1 (0.93); EBP2 (0.915); YLL044W (0.894); RIX7 (0.879); RAI1 (0.878); NSA1 (0.84); SLM3 (0.808); YTM1 (0.787); ERB1 (0.724); ENT4 (0.712); UTP18 (0.706); UTP15 (0.69); XRN1 (0.677); UTP25 (0.676); RNT1 (0.654)
Homologues (species, bitscore): CLP1 (Homo sapiens, 56.6); Clp1 (Mus musculus, 58.9); LOC565621 (Danio rerio, 58.9); NOL9 (Xenopus tropicalis, 68.2); CG8414 (Drosophila melanogaster, 66.2); nol-9 (Caenorhabditis elegans, 53.1); AT5G11010 (Arabidopsis thaliana, 70.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:55738-57636:+ | gene-YLL035W_AKU4011 | rna-NM_001181855.1_AKU4011 | cds-NP_013065.1_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:19679-21577:+ | gene-YLL035W_BG1 | rna-NM_001181855.1_BG1 | cds-NP_013065.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:65993-67891:+ | gene-YLL035W_Bruggeman | rna-NM_001181855.1_Bruggeman | cds-NP_013065.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:66616-68514:+ | gene-YLL035W_CAT1 | rna-NM_001181855.1_CAT1 | cds-NP_013065.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:63438-65336:+ | gene-YLL035W_CBS1585 | rna-NM_001181855.1_CBS1585 | cds-NP_013065.1_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:53637-55535:+ | gene-YLL035W_CBS436 | rna-NM_001181855.1_CBS436 | cds-NP_013065.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:63308-65206:+ | gene-YLL035W_CBS6412 | rna-NM_001181855.1_CBS6412 | cds-NP_013065.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:63434-65332:+ | gene-YLL035W_CBS6413 | rna-NM_001181855.1_CBS6413 | cds-NP_013065.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:53587-55485:+ | gene-YLL035W_CENPK1137D | rna-NM_001181855.1_CENPK1137D | cds-NP_013065.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:56135-58033:+ | gene-YLL035W_EthanolRed | rna-NM_001181855.1_EthanolRed | cds-NP_013065.1_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:55448-57346:+ | gene-YLL035W_FaliES1 | rna-NM_001181855.1_FaliES1 | cds-NP_013065.1_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000118.1:21657-23555:- | gene-YLL035W_JAY291 | rna-NM_001181855.1_JAY291 | cds-NP_013065.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:63404-65302:+ | gene-YLL035W_MUCL30387 | rna-NM_001181855.1_MUCL30387 | cds-NP_013065.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:68129-70027:+ | gene-YLL035W_MUCL30388 | rna-NM_001181855.1_MUCL30388 | cds-NP_013065.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:63647-65545:+ | gene-YLL035W_MUCL39482 | rna-NM_001181855.1_MUCL39482 | cds-NP_013065.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:63496-65394:+ | gene-YLL035W_MUCL42920 | rna-NM_001181855.1_MUCL42920 | cds-NP_013065.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:68554-70452:+ | gene-YLL035W_NCIM3186 | rna-NM_001181855.1_NCIM3186 | cds-NP_013065.1_NCIM3186 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:55513-57411:+ | gene-YLL035W_NCYC1407 | rna-NM_001181855.1_NCYC1407 | cds-NP_013065.1_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:62199-64097:+ | gene-YLL035W_PE2H3 | rna-NM_001181855.1_PE2H3 | cds-NP_013065.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:62008-63906:+ | gene-YLL035W_PE2H4 | rna-NM_001181855.1_PE2H4 | cds-NP_013065.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:68580-70478:+ | gene-YLL035W_S288C | rna-NM_001181855.1_S288C | cds-NP_013065.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000047.1:62101-63999:+ | gene-YLL035W_SA1 | rna-NM_001181855.1_SA1 | cds-NP_013065.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:55954-57852:+ | gene-YLL035W_ThermosaccDry | rna-NM_001181855.1_ThermosaccDry | cds-NP_013065.1_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:69775-71673:+ | gene-YLL035W_VR1 | rna-NM_001181855.1_VR1 | cds-NP_013065.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:55504-57402:+ | gene-YLL035W_ZTW1 | rna-NM_001181855.1_ZTW1 | cds-NP_013065.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:64125-66017:+ | gene-YLL035W_Sparadoxus | rna-NM_001181855.1_Sparadoxus | cds-NP_013065.1_Sparadoxus | 89.0 | 99.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |