Gene name: GPD1
Reference locus (S288C): YDL022W
Gene biotype: protein_coding
Description: NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import
Top 10 interactors (score): GUT2 (0.989); GPP2 (0.989); GPD2 (0.982); GPP1 (0.979); DAK1 (0.974); PNC1 (0.965); TPS2 (0.961); TPS1 (0.957); DAK2 (0.93); GPT2 (0.929); RTC3 (0.926); SCT1 (0.923); TSL1 (0.897); PGM2 (0.886); GRE3 (0.885); GLK1 (0.883); PAH1 (0.858); DPP1 (0.808); LPP1 (0.808); HSP42 (0.79)
Homologues (species, bitscore): GPD1 (Homo sapiens, 332.0); Gpd1 (Mus musculus, 332.0); gpd1b (Danio rerio, 327.8); gpd1l (Xenopus tropicalis, 325.9); Gpdh (Drosophila melanogaster, 313.5); gpdh-2 (Caenorhabditis elegans, 315.8); GPDHp (Arabidopsis thaliana, 315.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:397908-399083:+ | gene-YDL022W_AKU4011 | rna-NM_001180081.1_AKU4011 | cds-NP_010262.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:150796-151971:- | gene-YDL022W_BG1 | rna-NM_001180081.1_BG1 | cds-NP_010262.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:418408-419583:+ | gene-YDL022W_Bruggeman | rna-NM_001180081.1_Bruggeman | cds-NP_010262.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:411367-412542:+ | gene-YDL022W_CAT1 | rna-NM_001180081.1_CAT1 | cds-NP_010262.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:394321-395496:+ | gene-YDL022W_CBS1585 | rna-NM_001180081.1_CBS1585 | cds-NP_010262.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:411849-413024:+ | gene-YDL022W_CBS436 | rna-NM_001180081.1_CBS436 | cds-NP_010262.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:392090-393265:+ | gene-YDL022W_CBS6412 | rna-NM_001180081.1_CBS6412 | cds-NP_010262.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:414087-415262:+ | gene-YDL022W_CBS6413 | rna-NM_001180081.1_CBS6413 | cds-NP_010262.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:410684-411859:+ | gene-YDL022W_CENPK1137D | rna-NM_001180081.1_CENPK1137D | cds-NP_010262.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:406740-407915:+ | gene-YDL022W_EthanolRed | rna-NM_001180081.1_EthanolRed | cds-NP_010262.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:412932-414107:+ | gene-YDL022W_FaliES1 | rna-NM_001180081.1_FaliES1 | cds-NP_010262.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000370.1:27442-28617:+ | gene-YDL022W_JAY291 | rna-NM_001180081.1_JAY291 | cds-NP_010262.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:412297-413472:+ | gene-YDL022W_MUCL30387 | rna-NM_001180081.1_MUCL30387 | cds-NP_010262.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:402822-403997:+ | gene-YDL022W_MUCL30388 | rna-NM_001180081.1_MUCL30388 | cds-NP_010262.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:395995-397170:+ | gene-YDL022W_MUCL39482 | rna-NM_001180081.1_MUCL39482 | cds-NP_010262.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:317874-319049:+ | gene-YDL022W_MUCL42920 | rna-NM_001180081.1_MUCL42920 | cds-NP_010262.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:411748-412923:+ | gene-YDL022W_NCIM3186 | rna-NM_001180081.1_NCIM3186 | cds-NP_010262.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:395417-396592:+ | gene-YDL022W_NCYC1407 | rna-NM_001180081.1_NCYC1407 | cds-NP_010262.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:402924-404099:+ | gene-YDL022W_PE2H3 | rna-NM_001180081.1_PE2H3 | cds-NP_010262.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:402282-403457:+ | gene-YDL022W_PE2H4 | rna-NM_001180081.1_PE2H4 | cds-NP_010262.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:411825-413000:+ | gene-YDL022W_S288C | rna-NM_001180081.1_S288C | cds-NP_010262.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:21960-23135:- | gene-YDL022W_SA1 | rna-NM_001180081.1_SA1 | cds-NP_010262.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:412392-413567:+ | gene-YDL022W_ThermosaccDry | rna-NM_001180081.1_ThermosaccDry | cds-NP_010262.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:415420-416595:+ | gene-YDL022W_VR1 | rna-NM_001180081.1_VR1 | cds-NP_010262.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:410292-411467:+ | gene-YDL022W_ZTW1 | rna-NM_001180081.1_ZTW1 | cds-NP_010262.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:414313-415488:+ | gene-YDL022W_Sparadoxus | rna-NM_001180081.1_Sparadoxus | cds-NP_010262.1_Sparadoxus | 93.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |