Gene name: GPA1
Reference locus (S288C): YHR005C
Gene biotype: protein_coding
Description: Guanine nucleotide-binding protein alpha-1 subunit; Subunit of the G protein involved in pheromone response; GTP-binding alpha subunit of the heterotrimeric G protein; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): SST2 (0.999); STE4 (0.999); STE18 (0.999); STE2 (0.998); FUS3 (0.997); CDC42 (0.993); CYR1 (0.989); STE3 (0.984); HOG1 (0.972); FAR1 (0.968); DAL1 (0.965); STE5 (0.963); RGS2 (0.962); VPS15 (0.962); SLT2 (0.959); STE11 (0.948); GPR1 (0.943); SMK1 (0.941); VPS34 (0.94); STE7 (0.923)
Homologues (species, bitscore): GNAI1 (Homo sapiens, 295.0); Gnai1 (Mus musculus, 295.0); gnai3 (Danio rerio, 290.4); gnai1 (Xenopus tropicalis, 288.1); Galphai (Drosophila melanogaster, 288.5); goa-1 (Caenorhabditis elegans, 288.9); GPA1 (Arabidopsis thaliana, 196.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:102102-103520:- | gene-YHR005C_AKU4011 | rna-NM_001179135.1_AKU4011 | cds-NP_011868.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000053.1:21818-23236:- | gene-YHR005C_BG1 | rna-NM_001179135.1_BG1 | cds-NP_011868.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:108960-110378:- | gene-YHR005C_Bruggeman | rna-NM_001179135.1_Bruggeman | cds-NP_011868.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:102944-104362:- | gene-YHR005C_CAT1 | rna-NM_001179135.1_CAT1 | cds-NP_011868.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:102689-104107:- | gene-YHR005C_CBS1585 | rna-NM_001179135.1_CBS1585 | cds-NP_011868.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:95191-96609:- | gene-YHR005C_CBS436 | rna-NM_001179135.1_CBS436 | cds-NP_011868.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:102288-103706:- | gene-YHR005C_CBS6412 | rna-NM_001179135.1_CBS6412 | cds-NP_011868.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:102016-103434:- | gene-YHR005C_CBS6413 | rna-NM_001179135.1_CBS6413 | cds-NP_011868.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:106647-108065:- | gene-YHR005C_CENPK1137D | rna-NM_001179135.1_CENPK1137D | cds-NP_011868.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:102098-103516:- | gene-YHR005C_EthanolRed | rna-NM_001179135.1_EthanolRed | cds-NP_011868.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:102627-104045:- | gene-YHR005C_FaliES1 | rna-NM_001179135.1_FaliES1 | cds-NP_011868.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000064.1:17915-19333:+ | gene-YHR005C_JAY291 | rna-NM_001179135.1_JAY291 | cds-NP_011868.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:105700-107118:- | gene-YHR005C_MUCL30387 | rna-NM_001179135.1_MUCL30387 | cds-NP_011868.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:106911-108329:- | gene-YHR005C_MUCL30388 | rna-NM_001179135.1_MUCL30388 | cds-NP_011868.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:101715-103133:- | gene-YHR005C_MUCL39482 | rna-NM_001179135.1_MUCL39482 | cds-NP_011868.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:105620-107038:- | gene-YHR005C_MUCL42920 | rna-NM_001179135.1_MUCL42920 | cds-NP_011868.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:113381-114799:- | gene-YHR005C_NCIM3186 | rna-NM_001179135.1_NCIM3186 | cds-NP_011868.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:101133-102551:- | gene-YHR005C_NCYC1407 | rna-NM_001179135.1_NCYC1407 | cds-NP_011868.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:103337-104755:- | gene-YHR005C_PE2H3 | rna-NM_001179135.1_PE2H3 | cds-NP_011868.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:110778-112196:- | gene-YHR005C_PE2H4 | rna-NM_001179135.1_PE2H4 | cds-NP_011868.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:113499-114917:- | gene-YHR005C_S288C | rna-NM_001179135.1_S288C | cds-NP_011868.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000075.1:31635-33053:+ | gene-YHR005C_SA1 | rna-NM_001179135.1_SA1 | cds-NP_011868.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:103717-105135:- | gene-YHR005C_ThermosaccDry | rna-NM_001179135.1_ThermosaccDry | cds-NP_011868.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:109264-110682:- | gene-YHR005C_VR1 | rna-NM_001179135.1_VR1 | cds-NP_011868.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:94882-96300:- | gene-YHR005C_ZTW1 | rna-NM_001179135.1_ZTW1 | cds-NP_011868.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:101476-102894:- | gene-YHR005C_Sparadoxus | rna-NM_001179135.1_Sparadoxus | cds-NP_011868.1_Sparadoxus | 92.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |