Gene name: GLN1
Reference locus (S288C): YPR035W
Gene biotype: protein_coding
Description: Glutamate--ammonia ligase; Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
Top 10 interactors (score): GLT1 (0.999); GDH1 (0.997); GDH3 (0.996); GDH2 (0.994); ADE4 (0.993); PUT2 (0.973); URA2 (0.97); CPA2 (0.961); CPA1 (0.961); YMR084W (0.96); GCV2 (0.944); GFA1 (0.941); GAD1 (0.94); GCV1 (0.931); MEP2 (0.927); ECM38 (0.926); TRP5 (0.924); NIT1 (0.922); PRO2 (0.921); MEP1 (0.91)
Homologues (species, bitscore): GLUL (Homo sapiens, 418.7); Glul (Mus musculus, 418.3); glulb (Danio rerio, 427.2); glul (Xenopus tropicalis, 427.6); Gs2 (Drosophila melanogaster, 434.9); gln-3 (Caenorhabditis elegans, 463.4); GLN1.3 (Arabidopsis thaliana, 415.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:613870-614982:+ | gene-YPR035W_AKU4011 | rna-NM_001184132.2_AKU4011 | cds-NP_015360.2_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:282685-283797:- | gene-YPR035W_BG1 | rna-NM_001184132.2_BG1 | cds-NP_015360.2_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:691529-692641:+ | gene-YPR035W_Bruggeman | rna-NM_001184132.2_Bruggeman | cds-NP_015360.2_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:734497-735609:+ | gene-YPR035W_CAT1 | rna-NM_001184132.2_CAT1 | cds-NP_015360.2_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:617554-618666:+ | gene-YPR035W_CBS1585 | rna-NM_001184132.2_CBS1585 | cds-NP_015360.2_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:631939-633051:+ | gene-YPR035W_CBS436 | rna-NM_001184132.2_CBS436 | cds-NP_015360.2_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:621302-622414:+ | gene-YPR035W_CBS6412 | rna-NM_001184132.2_CBS6412 | cds-NP_015360.2_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:614501-615613:+ | gene-YPR035W_CBS6413 | rna-NM_001184132.2_CBS6413 | cds-NP_015360.2_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:642184-643296:+ | gene-YPR035W_CENPK1137D | rna-NM_001184132.2_CENPK1137D | cds-NP_015360.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:611798-612910:+ | gene-YPR035W_EthanolRed | rna-NM_001184132.2_EthanolRed | cds-NP_015360.2_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:619601-620713:+ | gene-YPR035W_FaliES1 | rna-NM_001184132.2_FaliES1 | cds-NP_015360.2_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000116.1:7182-8294:- | gene-YPR035W_JAY291 | rna-NM_001184132.2_JAY291 | cds-NP_015360.2_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:632741-633853:+ | gene-YPR035W_MUCL30387 | rna-NM_001184132.2_MUCL30387 | cds-NP_015360.2_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:631422-632534:+ | gene-YPR035W_MUCL30388 | rna-NM_001184132.2_MUCL30388 | cds-NP_015360.2_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:610811-611923:+ | gene-YPR035W_MUCL39482 | rna-NM_001184132.2_MUCL39482 | cds-NP_015360.2_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:673618-674730:+ | gene-YPR035W_MUCL42920 | rna-NM_001184132.2_MUCL42920 | cds-NP_015360.2_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:642191-643303:+ | gene-YPR035W_NCIM3186 | rna-NM_001184132.2_NCIM3186 | cds-NP_015360.2_NCIM3186 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:618742-619854:+ | gene-YPR035W_NCYC1407 | rna-NM_001184132.2_NCYC1407 | cds-NP_015360.2_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:624969-626081:+ | gene-YPR035W_PE2H3 | rna-NM_001184132.2_PE2H3 | cds-NP_015360.2_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:624617-625729:+ | gene-YPR035W_PE2H4 | rna-NM_001184132.2_PE2H4 | cds-NP_015360.2_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:642208-643320:+ | gene-YPR035W_S288C | rna-NM_001184132.2_S288C | cds-NP_015360.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000026.1:57454-58566:- | gene-YPR035W_SA1 | rna-NM_001184132.2_SA1 | cds-NP_015360.2_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:619401-620513:+ | gene-YPR035W_ThermosaccDry | rna-NM_001184132.2_ThermosaccDry | cds-NP_015360.2_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:635630-636742:+ | gene-YPR035W_VR1 | rna-NM_001184132.2_VR1 | cds-NP_015360.2_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:618718-619830:+ | gene-YPR035W_ZTW1 | rna-NM_001184132.2_ZTW1 | cds-NP_015360.2_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:619503-620615:+ | gene-YPR035W_Sparadoxus | rna-NM_001184132.2_Sparadoxus | cds-NP_015360.2_Sparadoxus | 94.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |