Gene name: GIS1
Reference locus (S288C): YDR096W
Gene biotype: protein_coding
Description: Transcriptional activator/repressor GIS1; Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
Top 10 interactors (score): RIM15 (0.994); SCH9 (0.988); JHD1 (0.946); SET2 (0.931); ECM5 (0.917); LRG1 (0.913); HHT2 (0.907); MSN4 (0.871); MSN2 (0.867); RPH1 (0.866); TPS2 (0.855); TOR1 (0.831); ESA1 (0.826); RAS2 (0.82); SAS2 (0.815); SAS3 (0.808); JHD2 (0.803); HTZ1 (0.802); CDC34 (0.802); CYR1 (0.79)
Homologues (species, bitscore): KDM4B (Homo sapiens, 156.4); Kdm4b (Mus musculus, 158.3); kdm4b (Danio rerio, 161.4); kdm4a (Xenopus tropicalis, 152.9); Kdm4A (Drosophila melanogaster, 152.5); jmjd-2 (Caenorhabditis elegans, 143.3); AT5G46910 (Arabidopsis thaliana, 101.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:614694-617378:+ | gene-YDR096W_AKU4011 | rna-NM_001180404.1_AKU4011 | cds-NP_010381.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:507899-510583:- | gene-YDR096W_BG1 | rna-NM_001180404.1_BG1 | cds-NP_010381.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:646784-649468:+ | gene-YDR096W_Bruggeman | rna-NM_001180404.1_Bruggeman | cds-NP_010381.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:631613-634297:+ | gene-YDR096W_CAT1 | rna-NM_001180404.1_CAT1 | cds-NP_010381.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:605714-608398:+ | gene-YDR096W_CBS1585 | rna-NM_001180404.1_CBS1585 | cds-NP_010381.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:630594-633278:+ | gene-YDR096W_CBS436 | rna-NM_001180404.1_CBS436 | cds-NP_010381.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:602128-604812:+ | gene-YDR096W_CBS6412 | rna-NM_001180404.1_CBS6412 | cds-NP_010381.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:630659-633343:+ | gene-YDR096W_CBS6413 | rna-NM_001180404.1_CBS6413 | cds-NP_010381.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:636146-638830:+ | gene-YDR096W_CENPK1137D | rna-NM_001180404.1_CENPK1137D | cds-NP_010381.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:616483-619167:+ | gene-YDR096W_EthanolRed | rna-NM_001180404.1_EthanolRed | cds-NP_010381.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:623276-625960:+ | gene-YDR096W_FaliES1 | rna-NM_001180404.1_FaliES1 | cds-NP_010381.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000358.1:5443-8127:- | gene-YDR096W_JAY291 | rna-NM_001180404.1_JAY291 | cds-NP_010381.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:631404-634088:+ | gene-YDR096W_MUCL30387 | rna-NM_001180404.1_MUCL30387 | cds-NP_010381.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:621712-624397:+ | gene-YDR096W_MUCL30388 | rna-NM_001180404.1_MUCL30388 | cds-NP_010381.1_MUCL30388 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:607084-609768:+ | gene-YDR096W_MUCL39482 | rna-NM_001180404.1_MUCL39482 | cds-NP_010381.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:538762-541446:+ | gene-YDR096W_MUCL42920 | rna-NM_001180404.1_MUCL42920 | cds-NP_010381.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:637062-639746:+ | gene-YDR096W_NCIM3186 | rna-NM_001180404.1_NCIM3186 | cds-NP_010381.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:605993-608677:+ | gene-YDR096W_NCYC1407 | rna-NM_001180404.1_NCYC1407 | cds-NP_010381.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:625461-628145:+ | gene-YDR096W_PE2H3 | rna-NM_001180404.1_PE2H3 | cds-NP_010381.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:624766-627450:+ | gene-YDR096W_PE2H4 | rna-NM_001180404.1_PE2H4 | cds-NP_010381.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:637139-639823:+ | gene-YDR096W_S288C | rna-NM_001180404.1_S288C | cds-NP_010381.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:5514-8198:- | gene-YDR096W_SA1 | rna-NM_001180404.1_SA1 | cds-NP_010381.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:622806-625490:+ | gene-YDR096W_ThermosaccDry | rna-NM_001180404.1_ThermosaccDry | cds-NP_010381.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:635358-638042:+ | gene-YDR096W_VR1 | rna-NM_001180404.1_VR1 | cds-NP_010381.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:620388-623072:+ | gene-YDR096W_ZTW1 | rna-NM_001180404.1_ZTW1 | cds-NP_010381.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:624968-627652:+ | gene-YDR096W_Sparadoxus | rna-NM_001180404.1_Sparadoxus | cds-NP_010381.1_Sparadoxus | 88.7 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |