GIR2 (YDR152W)


Gene profile

Gene name: GIR2
Reference locus (S288C): YDR152W
Gene biotype: protein_coding

Description: Protein GIR2; Highly-acidic RWD domain-containing cytoplasmic protein; forms a highly conserved complex with Rbg2p that is responsible for efficient cell growth under amino acid starvation and binds translational activator Gcn1p in dose-dependent manner according to stress level; associates with translating ribosomes; intrinsically unstructured protein whose stability is enhanced upon binding Rbg2p; Belongs to the RWDD1/GIR2 family

Top 10 interactors (score): RBG1 (0.999); RBG2 (0.999); TMA46 (0.984); GCN1 (0.967); YIH1 (0.922); EBP2 (0.914); LHP1 (0.914); KRI1 (0.898); GIM5 (0.876); YLR419W (0.749); SLH1 (0.748); GCN2 (0.727); ESF1 (0.719); MAK16 (0.706); RIE1 (0.697); YCR087C-A (0.652); NOP12 (0.646); BMS1 (0.643); RRP36 (0.636); TEF1 (0.635)

Homologues (species, bitscore): RWDD1 (Homo sapiens, 89.4); Rwdd1 (Mus musculus, 89.7); rwdd1 (Danio rerio, 88.2); rwdd1 (Xenopus tropicalis, 75.1); CG5515 (Drosophila melanogaster, 61.2); T26E3.4 (Caenorhabditis elegans, 73.9); AT1G51730 (Arabidopsis thaliana, 62.4)

External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser


Comparative analysis of strains

Search table

strain assembly application macro_region gene_coord geneID rnaID protID %id %cov_exon status copyNumber copyID nORFs match_ref_CDS validORF missing_startCodon missing_stopCodon outOfFrame_stopCodon
AKU4011 GCA_001738255.1 Sake Asia CM005298.1:737023-737820:+ gene-YDR152W_AKU4011 rna-NM_001180459.3_AKU4011 cds-NP_010436.3_AKU4011 99.8 100.0 Verified 1 1 1 True True False False False
BG1 GCA_001932575.1 Bioethanol South America MSHP01000080.1:388931-389728:- gene-YDR152W_BG1 rna-NM_001180459.3_BG1 cds-NP_010436.3_BG1 100.0 100.0 Verified 1 1 1 True True False False False
Bruggeman GCA_001738585.1 Bread Not Applicable CM005506.1:768520-769317:+ gene-YDR152W_Bruggeman rna-NM_001180459.3_Bruggeman cds-NP_010436.3_Bruggeman 99.8 100.0 Verified 1 1 1 True True False False False
CAT1 GCA_001738705.1 Bioethanol South America CM005522.1:755810-756607:+ gene-YDR152W_CAT1 rna-NM_001180459.3_CAT1 cds-NP_010436.3_CAT1 99.8 100.0 Verified 1 1 1 True True False False False
CBS1585 GCA_001738375.1 Sake Asia CM005362.1:727391-728188:+ gene-YDR152W_CBS1585 rna-NM_001180459.3_CBS1585 cds-NP_010436.3_CBS1585 99.8 100.0 Verified 1 1 1 True True False False False
CBS436 GCA_001738355.1 Sake Asia CM005346.1:753565-754362:+ gene-YDR152W_CBS436 rna-NM_001180459.3_CBS436 cds-NP_010436.3_CBS436 100.0 100.0 Mismatch 1 1 1 True True False False False
CBS6412 GCA_001738345.1 Sake Asia CM005330.1:722877-723674:+ gene-YDR152W_CBS6412 rna-NM_001180459.3_CBS6412 cds-NP_010436.3_CBS6412 99.7 100.0 Mismatch 1 1 1 True True False False False
CBS6413 GCA_001738265.1 Sake Asia CM005314.1:751289-752086:+ gene-YDR152W_CBS6413 rna-NM_001180459.3_CBS6413 cds-NP_010436.3_CBS6413 99.8 100.0 Verified 1 1 1 True True False False False
CENPK1137D GCA_000269885.1 Laboratory Not Applicable CM001525.1:766388-767185:+ gene-YDR152W_CENPK1137D rna-NM_001180459.3_CENPK1137D cds-NP_010436.3_CENPK1137D 99.7 100.0 Verified 1 1 1 True True False False False
EthanolRed GCA_001738615.1 Bioethanol Asia CM005474.1:736847-737644:+ gene-YDR152W_EthanolRed rna-NM_001180459.3_EthanolRed cds-NP_010436.3_EthanolRed 99.7 100.0 Verified 1 1 1 True True False False False
FaliES1 GCA_001738715.1 Bioethanol Asia CM005538.1:745059-745856:+ gene-YDR152W_FaliES1 rna-NM_001180459.3_FaliES1 cds-NP_010436.3_FaliES1 99.7 100.0 Verified 1 1 1 True True False False False
JAY291 GCA_000182315.2 Bioethanol South America ACFL01000401.1:5976-6773:+ gene-YDR152W_JAY291 rna-NM_001180459.3_JAY291 cds-NP_010436.3_JAY291 99.7 100.0 Verified 1 1 1 True True False False False
MUCL30387 GCA_001738515.1 Bread Europe CM005410.1:753491-754288:+ gene-YDR152W_MUCL30387 rna-NM_001180459.3_MUCL30387 cds-NP_010436.3_MUCL30387 99.8 100.0 Verified 1 1 1 True True False False False
MUCL30388 GCA_001738495.1 Bread Europe CM005442.1:742408-743205:+ gene-YDR152W_MUCL30388 rna-NM_001180459.3_MUCL30388 cds-NP_010436.3_MUCL30388 99.8 100.0 Verified 1 1 1 True True False False False
MUCL39482 GCA_001738235.1 Sake Asia CM005282.1:728818-729615:+ gene-YDR152W_MUCL39482 rna-NM_001180459.3_MUCL39482 cds-NP_010436.3_MUCL39482 99.8 100.0 Verified 1 1 1 True True False False False
MUCL42920 GCA_001738485.1 Bread Europe CM005426.1:666648-667445:+ gene-YDR152W_MUCL42920 rna-NM_001180459.3_MUCL42920 cds-NP_010436.3_MUCL42920 99.8 100.0 Verified 1 1 1 False True False False False
NCIM3186 GCA_001029075.1 Bioethanol Asia CP011813.1:765629-766426:+ gene-YDR152W_NCIM3186 rna-NM_001180459.3_NCIM3186 cds-NP_010436.3_NCIM3186 99.7 100.0 Verified 1 1 1 False True False False False
NCYC1407 GCA_001738225.1 Sake Asia CM005266.1:728223-729020:+ gene-YDR152W_NCYC1407 rna-NM_001180459.3_NCYC1407 cds-NP_010436.3_NCYC1407 99.6 100.0 Verified 1 1 1 False True False False False
PE2H3 GCA_905220325.1 Bioethanol South America HG994143.1:747415-748212:+ gene-YDR152W_PE2H3 rna-NM_001180459.3_PE2H3 cds-NP_010436.3_PE2H3 99.8 100.0 Verified 1 1 1 False True False False False
PE2H4 GCA_905220315.1 Bioethanol South America LR999875.1:746720-747517:+ gene-YDR152W_PE2H4 rna-NM_001180459.3_PE2H4 cds-NP_010436.3_PE2H4 99.8 100.0 Verified 1 1 1 False True False False False
S288C GCF_000146045.2 Laboratory Not applicable NC_001136.10:765706-766503:+ gene-YDR152W_S288C rna-NM_001180459.3_S288C cds-NP_010436.3_S288C 100.0 100.0 Verified 1 1 1 True True False False False
SA1 GCA_004114265.1 Bioethanol South America SDIA01000009.1:112926-113723:+ gene-YDR152W_SA1 rna-NM_001180459.3_SA1 cds-NP_010436.3_SA1 99.7 100.0 Verified 1 1 1 False True False False False
ThermosaccDry GCA_001738605.1 Bioethanol Asia CM005490.1:743194-743991:+ gene-YDR152W_ThermosaccDry rna-NM_001180459.3_ThermosaccDry cds-NP_010436.3_ThermosaccDry 99.7 100.0 Verified 1 1 1 True True False False False
VR1 GCA_001738595.1 Bioethanol South America CM005458.1:758124-758921:+ gene-YDR152W_VR1 rna-NM_001180459.3_VR1 cds-NP_010436.3_VR1 99.8 100.0 Verified 1 1 1 True True False False False
ZTW1 GCA_000308935.1 Bioethanol Asia AMDD01000007.1:5948-6745:+ gene-YDR152W_ZTW1 rna-NM_001180459.3_ZTW1 cds-NP_010436.3_ZTW1 99.8 100.0 Verified 1 1 1 True True False False False
Sparadoxus GCF_002079055.1 Not applicable Not applicable NC_047490.1:749482-750285:+ gene-YDR152W_Sparadoxus rna-NM_001180459.3_Sparadoxus cds-NP_010436.3_Sparadoxus 90.6 100.0 Unannotated 1 1 0 False False False False True

Additional files