Gene name: GIR2
Reference locus (S288C): YDR152W
Gene biotype: protein_coding
Description: Protein GIR2; Highly-acidic RWD domain-containing cytoplasmic protein; forms a highly conserved complex with Rbg2p that is responsible for efficient cell growth under amino acid starvation and binds translational activator Gcn1p in dose-dependent manner according to stress level; associates with translating ribosomes; intrinsically unstructured protein whose stability is enhanced upon binding Rbg2p; Belongs to the RWDD1/GIR2 family
Top 10 interactors (score): RBG1 (0.999); RBG2 (0.999); TMA46 (0.984); GCN1 (0.967); YIH1 (0.922); EBP2 (0.914); LHP1 (0.914); KRI1 (0.898); GIM5 (0.876); YLR419W (0.749); SLH1 (0.748); GCN2 (0.727); ESF1 (0.719); MAK16 (0.706); RIE1 (0.697); YCR087C-A (0.652); NOP12 (0.646); BMS1 (0.643); RRP36 (0.636); TEF1 (0.635)
Homologues (species, bitscore): RWDD1 (Homo sapiens, 89.4); Rwdd1 (Mus musculus, 89.7); rwdd1 (Danio rerio, 88.2); rwdd1 (Xenopus tropicalis, 75.1); CG5515 (Drosophila melanogaster, 61.2); T26E3.4 (Caenorhabditis elegans, 73.9); AT1G51730 (Arabidopsis thaliana, 62.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:737023-737820:+ | gene-YDR152W_AKU4011 | rna-NM_001180459.3_AKU4011 | cds-NP_010436.3_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:388931-389728:- | gene-YDR152W_BG1 | rna-NM_001180459.3_BG1 | cds-NP_010436.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:768520-769317:+ | gene-YDR152W_Bruggeman | rna-NM_001180459.3_Bruggeman | cds-NP_010436.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:755810-756607:+ | gene-YDR152W_CAT1 | rna-NM_001180459.3_CAT1 | cds-NP_010436.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:727391-728188:+ | gene-YDR152W_CBS1585 | rna-NM_001180459.3_CBS1585 | cds-NP_010436.3_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:753565-754362:+ | gene-YDR152W_CBS436 | rna-NM_001180459.3_CBS436 | cds-NP_010436.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:722877-723674:+ | gene-YDR152W_CBS6412 | rna-NM_001180459.3_CBS6412 | cds-NP_010436.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:751289-752086:+ | gene-YDR152W_CBS6413 | rna-NM_001180459.3_CBS6413 | cds-NP_010436.3_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:766388-767185:+ | gene-YDR152W_CENPK1137D | rna-NM_001180459.3_CENPK1137D | cds-NP_010436.3_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:736847-737644:+ | gene-YDR152W_EthanolRed | rna-NM_001180459.3_EthanolRed | cds-NP_010436.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:745059-745856:+ | gene-YDR152W_FaliES1 | rna-NM_001180459.3_FaliES1 | cds-NP_010436.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000401.1:5976-6773:+ | gene-YDR152W_JAY291 | rna-NM_001180459.3_JAY291 | cds-NP_010436.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:753491-754288:+ | gene-YDR152W_MUCL30387 | rna-NM_001180459.3_MUCL30387 | cds-NP_010436.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:742408-743205:+ | gene-YDR152W_MUCL30388 | rna-NM_001180459.3_MUCL30388 | cds-NP_010436.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:728818-729615:+ | gene-YDR152W_MUCL39482 | rna-NM_001180459.3_MUCL39482 | cds-NP_010436.3_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:666648-667445:+ | gene-YDR152W_MUCL42920 | rna-NM_001180459.3_MUCL42920 | cds-NP_010436.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:765629-766426:+ | gene-YDR152W_NCIM3186 | rna-NM_001180459.3_NCIM3186 | cds-NP_010436.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:728223-729020:+ | gene-YDR152W_NCYC1407 | rna-NM_001180459.3_NCYC1407 | cds-NP_010436.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:747415-748212:+ | gene-YDR152W_PE2H3 | rna-NM_001180459.3_PE2H3 | cds-NP_010436.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:746720-747517:+ | gene-YDR152W_PE2H4 | rna-NM_001180459.3_PE2H4 | cds-NP_010436.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:765706-766503:+ | gene-YDR152W_S288C | rna-NM_001180459.3_S288C | cds-NP_010436.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000009.1:112926-113723:+ | gene-YDR152W_SA1 | rna-NM_001180459.3_SA1 | cds-NP_010436.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:743194-743991:+ | gene-YDR152W_ThermosaccDry | rna-NM_001180459.3_ThermosaccDry | cds-NP_010436.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:758124-758921:+ | gene-YDR152W_VR1 | rna-NM_001180459.3_VR1 | cds-NP_010436.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000007.1:5948-6745:+ | gene-YDR152W_ZTW1 | rna-NM_001180459.3_ZTW1 | cds-NP_010436.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:749482-750285:+ | gene-YDR152W_Sparadoxus | rna-NM_001180459.3_Sparadoxus | cds-NP_010436.3_Sparadoxus | 90.6 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |