Gene name: GET3
Reference locus (S288C): YDL100C
Gene biotype: protein_coding
Description: ATPase GET3; Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; functions as a chaperone under ATP-depleted oxidative stress conditions; subunit of GET complex, involved in ATP dependent Golgi to ER trafficking and insertion of tail-anchored (TA) proteins into ER membrane under non-stress conditions; binds as dimer to transmembrane domain (TMD) cargo, shielding TMDs from aqueous solvent; protein abundance increases under DNA replication stress
Top 10 interactors (score): GET4 (0.999); GET2 (0.999); GET1 (0.999); MDY2 (0.999); SGT2 (0.998); SED5 (0.957); SEC22 (0.953); SRP54 (0.914); SBH1 (0.901); SEC61 (0.893); GOT1 (0.892); PEX15 (0.86); SBH2 (0.855); ENV10 (0.85); PEX3 (0.836); MSP1 (0.833); YBR137W (0.813); YSY6 (0.794); PEP12 (0.789); TLG2 (0.752)
Homologues (species, bitscore): ASNA1 (Homo sapiens, 305.4); Asna1 (Mus musculus, 305.4); asna1 (Danio rerio, 306.2); asna1 (Xenopus tropicalis, 273.1); CG1598 (Drosophila melanogaster, 313.2); asna-1 (Caenorhabditis elegans, 293.5); AT1G01910 (Arabidopsis thaliana, 283.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:266720-267784:- | gene-YDL100C_AKU4011 | rna-NM_001180159.1_AKU4011 | cds-NP_010183.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:282157-283221:+ | gene-YDL100C_BG1 | rna-NM_001180159.1_BG1 | cds-NP_010183.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:284146-285210:- | gene-YDL100C_Bruggeman | rna-NM_001180159.1_Bruggeman | cds-NP_010183.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:280883-281947:- | gene-YDL100C_CAT1 | rna-NM_001180159.1_CAT1 | cds-NP_010183.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:264991-266055:- | gene-YDL100C_CBS1585 | rna-NM_001180159.1_CBS1585 | cds-NP_010183.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:281661-282725:- | gene-YDL100C_CBS436 | rna-NM_001180159.1_CBS436 | cds-NP_010183.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:263419-264483:- | gene-YDL100C_CBS6412 | rna-NM_001180159.1_CBS6412 | cds-NP_010183.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:283044-284108:- | gene-YDL100C_CBS6413 | rna-NM_001180159.1_CBS6413 | cds-NP_010183.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:280917-281981:- | gene-YDL100C_CENPK1137D | rna-NM_001180159.1_CENPK1137D | cds-NP_010183.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:277753-278817:- | gene-YDL100C_EthanolRed | rna-NM_001180159.1_EthanolRed | cds-NP_010183.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:283725-284789:- | gene-YDL100C_FaliES1 | rna-NM_001180159.1_FaliES1 | cds-NP_010183.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000010.1:53778-54842:- | gene-YDL100C_JAY291 | rna-NM_001180159.1_JAY291 | cds-NP_010183.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:281909-282973:- | gene-YDL100C_MUCL30387 | rna-NM_001180159.1_MUCL30387 | cds-NP_010183.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:272684-273748:- | gene-YDL100C_MUCL30388 | rna-NM_001180159.1_MUCL30388 | cds-NP_010183.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:266097-267161:- | gene-YDL100C_MUCL39482 | rna-NM_001180159.1_MUCL39482 | cds-NP_010183.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:187865-188929:- | gene-YDL100C_MUCL42920 | rna-NM_001180159.1_MUCL42920 | cds-NP_010183.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:282035-283099:- | gene-YDL100C_NCIM3186 | rna-NM_001180159.1_NCIM3186 | cds-NP_010183.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:266112-267176:- | gene-YDL100C_NCYC1407 | rna-NM_001180159.1_NCYC1407 | cds-NP_010183.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:272895-273959:- | gene-YDL100C_PE2H3 | rna-NM_001180159.1_PE2H3 | cds-NP_010183.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:272896-273960:- | gene-YDL100C_PE2H4 | rna-NM_001180159.1_PE2H4 | cds-NP_010183.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:282112-283176:- | gene-YDL100C_S288C | rna-NM_001180159.1_S288C | cds-NP_010183.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:151746-152810:+ | gene-YDL100C_SA1 | rna-NM_001180159.1_SA1 | cds-NP_010183.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:283236-284300:- | gene-YDL100C_ThermosaccDry | rna-NM_001180159.1_ThermosaccDry | cds-NP_010183.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:285314-286378:- | gene-YDL100C_VR1 | rna-NM_001180159.1_VR1 | cds-NP_010183.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:281161-282225:- | gene-YDL100C_ZTW1 | rna-NM_001180159.1_ZTW1 | cds-NP_010183.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:283284-284348:- | gene-YDL100C_Sparadoxus | rna-NM_001180159.1_Sparadoxus | cds-NP_010183.1_Sparadoxus | 93.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |