Gene name: GCN5
Reference locus (S288C): YGR252W
Gene biotype: protein_coding
Description: Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation; Belongs to the acetyltransferase family. GCN5 subfamily
Top 10 interactors (score): HHF1 (0.999); TAF6 (0.999); TAF10 (0.999); HFI1 (0.999); NGG1 (0.999); TAF5 (0.999); TAF9 (0.999); HHT2 (0.999); SGF11 (0.999); TRA1 (0.999); UBP8 (0.999); ADA2 (0.999); SAS3 (0.999); SGF29 (0.999); SPT3 (0.999); TAF12 (0.999); SGF73 (0.999); SPT20 (0.999); HHT1 (0.999); SPT8 (0.999)
Homologues (species, bitscore): KAT2B (Homo sapiens, 313.9); Kat2b (Mus musculus, 311.6); kat2b (Danio rerio, 306.2); kat2a (Xenopus tropicalis, 308.9); Gcn5 (Drosophila melanogaster, 297.0); pcaf-1 (Caenorhabditis elegans, 260.0); HAG1 (Arabidopsis thaliana, 341.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:962297-963616:+ | gene-YGR252W_AKU4011 | rna-NM_001181381.1_AKU4011 | cds-NP_011768.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:242467-243786:+ | gene-YGR252W_BG1 | rna-NM_001181381.1_BG1 | cds-NP_011768.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:970815-972134:+ | gene-YGR252W_Bruggeman | rna-NM_001181381.1_Bruggeman | cds-NP_011768.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:969752-971071:+ | gene-YGR252W_CAT1 | rna-NM_001181381.1_CAT1 | cds-NP_011768.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:965168-966487:+ | gene-YGR252W_CBS1585 | rna-NM_001181381.1_CBS1585 | cds-NP_011768.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:968797-970116:+ | gene-YGR252W_CBS436 | rna-NM_001181381.1_CBS436 | cds-NP_011768.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:956057-957376:+ | gene-YGR252W_CBS6412 | rna-NM_001181381.1_CBS6412 | cds-NP_011768.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:962112-963431:+ | gene-YGR252W_CBS6413 | rna-NM_001181381.1_CBS6413 | cds-NP_011768.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:996551-997870:+ | gene-YGR252W_CENPK1137D | rna-NM_001181381.1_CENPK1137D | cds-NP_011768.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:950149-951468:+ | gene-YGR252W_EthanolRed | rna-NM_001181381.1_EthanolRed | cds-NP_011768.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:954955-956274:+ | gene-YGR252W_FaliES1 | rna-NM_001181381.1_FaliES1 | cds-NP_011768.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000076.1:74038-75357:- | gene-YGR252W_JAY291 | rna-NM_001181381.1_JAY291 | cds-NP_011768.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:968552-969871:+ | gene-YGR252W_MUCL30387 | rna-NM_001181381.1_MUCL30387 | cds-NP_011768.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:966684-968003:+ | gene-YGR252W_MUCL30388 | rna-NM_001181381.1_MUCL30388 | cds-NP_011768.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:960273-961592:+ | gene-YGR252W_MUCL39482 | rna-NM_001181381.1_MUCL39482 | cds-NP_011768.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:978148-979467:+ | gene-YGR252W_MUCL42920 | rna-NM_001181381.1_MUCL42920 | cds-NP_011768.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:996869-998188:+ | gene-YGR252W_NCIM3186 | rna-NM_001181381.1_NCIM3186 | cds-NP_011768.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:955902-957221:+ | gene-YGR252W_NCYC1407 | rna-NM_001181381.1_NCYC1407 | cds-NP_011768.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:981092-982411:+ | gene-YGR252W_PE2H3 | rna-NM_001181381.1_PE2H3 | cds-NP_011768.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:985931-987250:+ | gene-YGR252W_PE2H4 | rna-NM_001181381.1_PE2H4 | cds-NP_011768.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:996869-998188:+ | gene-YGR252W_S288C | rna-NM_001181381.1_S288C | cds-NP_011768.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000045.1:3229-4548:- | gene-YGR252W_SA1 | rna-NM_001181381.1_SA1 | cds-NP_011768.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:975475-976794:+ | gene-YGR252W_ThermosaccDry | rna-NM_001181381.1_ThermosaccDry | cds-NP_011768.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:1081253-1082572:+ | gene-YGR252W_VR1 | rna-NM_001181381.1_VR1 | cds-NP_011768.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:276887-278206:+ | gene-YGR252W_ZTW1 | rna-NM_001181381.1_ZTW1 | cds-NP_011768.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:967491-968810:+ | gene-YGR252W_Sparadoxus | rna-NM_001181381.1_Sparadoxus | cds-NP_011768.1_Sparadoxus | 92.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |