Gene name: GCN3
Reference locus (S288C): YKR026C
Gene biotype: protein_coding
Description: Alpha subunit of translation initiation factor eIF2B; guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; positive regulator of GCN4 expression; assembles into filaments with Gcd2p, Gcd6p, Gcd7p, and Sui2p as cells approach stationary phase and under cytosolic acidification and starvation conditions; human homolog EIF2B1 can complement yeast null mutant; Belongs to the eIF-2B alpha/beta/delta subunits family
Top 10 interactors (score): SUI2 (0.999); GCD7 (0.999); GCD11 (0.999); GCD2 (0.999); SUI3 (0.999); GCD6 (0.999); GCD1 (0.999); GCN2 (0.992); PRE5 (0.966); RIC1 (0.9); RGP1 (0.9); GCN4 (0.898); GCN1 (0.894); URA7 (0.83); TIF5 (0.822); GCD10 (0.817); GCD14 (0.769); PRT1 (0.762); RBG2 (0.761); IST1 (0.747)
Homologues (species, bitscore): EIF2B1 (Homo sapiens, 230.3); Eif2b1 (Mus musculus, 223.4); eif2b1 (Danio rerio, 196.8); eif2b1 (Xenopus tropicalis, 235.3); Eif2b (Drosophila melanogaster, 194.9); ZK1098.4 (Caenorhabditis elegans, 181.8); AT1G53880.1 (Arabidopsis thaliana, 222.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:474409-475326:- | gene-YKR026C_AKU4011 | rna-NM_001179816.1_AKU4011 | cds-NP_012951.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:168160-169077:+ | gene-YKR026C_BG1 | rna-NM_001179816.1_BG1 | cds-NP_012951.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:496079-496996:- | gene-YKR026C_Bruggeman | rna-NM_001179816.1_Bruggeman | cds-NP_012951.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:491822-492739:- | gene-YKR026C_CAT1 | rna-NM_001179816.1_CAT1 | cds-NP_012951.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:487149-488066:- | gene-YKR026C_CBS1585 | rna-NM_001179816.1_CBS1585 | cds-NP_012951.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:485978-486895:- | gene-YKR026C_CBS436 | rna-NM_001179816.1_CBS436 | cds-NP_012951.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:471310-472227:- | gene-YKR026C_CBS6412 | rna-NM_001179816.1_CBS6412 | cds-NP_012951.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:486977-487894:- | gene-YKR026C_CBS6413 | rna-NM_001179816.1_CBS6413 | cds-NP_012951.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:488480-489397:- | gene-YKR026C_CENPK1137D | rna-NM_001179816.1_CENPK1137D | cds-NP_012951.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:484878-485795:- | gene-YKR026C_EthanolRed | rna-NM_001179816.1_EthanolRed | cds-NP_012951.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:487808-488725:- | gene-YKR026C_FaliES1 | rna-NM_001179816.1_FaliES1 | cds-NP_012951.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000077.1:65033-65950:+ | gene-YKR026C_JAY291 | rna-NM_001179816.1_JAY291 | cds-NP_012951.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:495395-496312:- | gene-YKR026C_MUCL30387 | rna-NM_001179816.1_MUCL30387 | cds-NP_012951.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:491088-492005:- | gene-YKR026C_MUCL30388 | rna-NM_001179816.1_MUCL30388 | cds-NP_012951.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:486466-487383:- | gene-YKR026C_MUCL39482 | rna-NM_001179816.1_MUCL39482 | cds-NP_012951.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:492238-493155:- | gene-YKR026C_MUCL42920 | rna-NM_001179816.1_MUCL42920 | cds-NP_012951.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:488727-489644:- | gene-YKR026C_NCIM3186 | rna-NM_001179816.1_NCIM3186 | cds-NP_012951.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:486673-487590:- | gene-YKR026C_NCYC1407 | rna-NM_001179816.1_NCYC1407 | cds-NP_012951.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:511660-512577:- | gene-YKR026C_PE2H3 | rna-NM_001179816.1_PE2H3 | cds-NP_012951.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:496383-497300:- | gene-YKR026C_PE2H4 | rna-NM_001179816.1_PE2H4 | cds-NP_012951.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:488738-489655:- | gene-YKR026C_S288C | rna-NM_001179816.1_S288C | cds-NP_012951.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000078.1:24094-25011:+ | gene-YKR026C_SA1 | rna-NM_001179816.1_SA1 | cds-NP_012951.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:487062-487979:- | gene-YKR026C_ThermosaccDry | rna-NM_001179816.1_ThermosaccDry | cds-NP_012951.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:486680-487597:- | gene-YKR026C_VR1 | rna-NM_001179816.1_VR1 | cds-NP_012951.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:485109-486026:- | gene-YKR026C_ZTW1 | rna-NM_001179816.1_ZTW1 | cds-NP_012951.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:510551-511468:- | gene-YKR026C_Sparadoxus | rna-NM_001179816.1_Sparadoxus | cds-NP_012951.1_Sparadoxus | 92.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |