Gene name: GCN2
Reference locus (S288C): YDR283C
Gene biotype: protein_coding
Description: eIF-2-alpha kinase GCN2; Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
Top 10 interactors (score): SUI2 (0.999); GCN1 (0.999); SUI3 (0.998); GCD11 (0.998); GCN20 (0.992); GCN3 (0.992); GCN4 (0.992); TOR1 (0.987); GCD7 (0.973); KOG1 (0.97); TOR2 (0.968); GCD6 (0.952); GCD2 (0.95); YEF3 (0.949); CDC33 (0.942); KRS1 (0.937); TIF5 (0.935); SIT4 (0.924); LST8 (0.918); TEF2 (0.918)
Homologues (species, bitscore): EIF2AK4 (Homo sapiens, 398.7); Eif2ak4 (Mus musculus, 421.8); eif2ak4 (Danio rerio, 267.7); eif2ak4 (Xenopus tropicalis, 393.7); Gcn2 (Drosophila melanogaster, 297.4); gcn-2 (Caenorhabditis elegans, 183.3); GCN2 (Arabidopsis thaliana, 288.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:977059-982038:- | gene-YDR283C_AKU4011 | rna-NM_001180591.3_AKU4011 | cds-NP_010569.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:149521-154500:+ | gene-YDR283C_BG1 | rna-NM_001180591.3_BG1 | cds-NP_010569.3_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1004328-1009307:- | gene-YDR283C_Bruggeman | rna-NM_001180591.3_Bruggeman | cds-NP_010569.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:991340-996319:- | gene-YDR283C_CAT1 | rna-NM_001180591.3_CAT1 | cds-NP_010569.3_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:971505-976484:- | gene-YDR283C_CBS1585 | rna-NM_001180591.3_CBS1585 | cds-NP_010569.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:989868-994847:- | gene-YDR283C_CBS436 | rna-NM_001180591.3_CBS436 | cds-NP_010569.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:968186-973165:- | gene-YDR283C_CBS6412 | rna-NM_001180591.3_CBS6412 | cds-NP_010569.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:989424-994403:- | gene-YDR283C_CBS6413 | rna-NM_001180591.3_CBS6413 | cds-NP_010569.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1023716-1028695:- | gene-YDR283C_CENPK1137D | rna-NM_001180591.3_CENPK1137D | cds-NP_010569.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:975599-980578:- | gene-YDR283C_EthanolRed | rna-NM_001180591.3_EthanolRed | cds-NP_010569.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:983801-988780:- | gene-YDR283C_FaliES1 | rna-NM_001180591.3_FaliES1 | cds-NP_010569.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000130.1:1625-6605:- | gene-YDR283C_JAY291 | rna-NM_001180591.3_JAY291 | cds-NP_010569.3_JAY291 | 99.9 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:989844-994823:- | gene-YDR283C_MUCL30387 | rna-NM_001180591.3_MUCL30387 | cds-NP_010569.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:976911-981890:- | gene-YDR283C_MUCL30388 | rna-NM_001180591.3_MUCL30388 | cds-NP_010569.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:963311-968290:- | gene-YDR283C_MUCL39482 | rna-NM_001180591.3_MUCL39482 | cds-NP_010569.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:903291-908270:- | gene-YDR283C_MUCL42920 | rna-NM_001180591.3_MUCL42920 | cds-NP_010569.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1024993-1029972:- | gene-YDR283C_NCIM3186 | rna-NM_001180591.3_NCIM3186 | cds-NP_010569.3_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:976601-981580:- | gene-YDR283C_NCYC1407 | rna-NM_001180591.3_NCYC1407 | cds-NP_010569.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:987598-992577:- | gene-YDR283C_PE2H3 | rna-NM_001180591.3_PE2H3 | cds-NP_010569.3_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:993183-998162:- | gene-YDR283C_PE2H4 | rna-NM_001180591.3_PE2H4 | cds-NP_010569.3_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1025070-1030049:- | gene-YDR283C_S288C | rna-NM_001180591.3_S288C | cds-NP_010569.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000025.1:1805-6784:- | gene-YDR283C_SA1 | rna-NM_001180591.3_SA1 | cds-NP_010569.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:988086-993065:- | gene-YDR283C_ThermosaccDry | rna-NM_001180591.3_ThermosaccDry | cds-NP_010569.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1004024-1009003:- | gene-YDR283C_VR1 | rna-NM_001180591.3_VR1 | cds-NP_010569.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:32209-37188:- | gene-YDR283C_ZTW1 | rna-NM_001180591.3_ZTW1 | cds-NP_010569.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:983584-988566:- | gene-YDR283C_Sparadoxus | rna-NM_001180591.3_Sparadoxus | cds-NP_010569.3_Sparadoxus | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |