Gene name: GCG1
Reference locus (S288C): YER163C
Gene biotype: protein_coding
Description: Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle
Top 10 interactors (score): ECM38 (0.918); GLR1 (0.918); GSH2 (0.905); OXP1 (0.902); DUG1 (0.9); GTT1 (0.9); PRX1 (0.9); URE2 (0.9); YMR085W (0.845); YGR127W (0.818); CMR2 (0.817); YBR062C (0.78); YER152C (0.768); BLM10 (0.766); YOR012W (0.758); YGR111W (0.753); TDA3 (0.749); YML082W (0.747); TMC1 (0.746); YIL165C (0.745)
Homologues (species, bitscore): CHAC2 (Homo sapiens, 106.3); Chac2 (Mus musculus, 106.7); chac2 (Danio rerio, 124.4); chac2 (Xenopus tropicalis, 105.5); CG2540 (Drosophila melanogaster, 97.4); F22F7.7 (Caenorhabditis elegans, 73.2); AT1G44790 (Arabidopsis thaliana, 95.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:484638-485336:- | gene-YER163C_AKU4011 | rna-NM_001179053.3_AKU4011 | cds-NP_011090.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000176.1:48037-48735:+ | gene-YER163C_BG1 | rna-NM_001179053.3_BG1 | cds-NP_011090.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:497347-498045:- | gene-YER163C_Bruggeman | rna-NM_001179053.3_Bruggeman | cds-NP_011090.3_Bruggeman | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:483944-484642:- | gene-YER163C_CAT1 | rna-NM_001179053.3_CAT1 | cds-NP_011090.3_CAT1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:484447-485145:- | gene-YER163C_CBS1585 | rna-NM_001179053.3_CBS1585 | cds-NP_011090.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:494330-495028:- | gene-YER163C_CBS436 | rna-NM_001179053.3_CBS436 | cds-NP_011090.3_CBS436 | 98.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:482423-483121:- | gene-YER163C_CBS6412 | rna-NM_001179053.3_CBS6412 | cds-NP_011090.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:490993-491691:- | gene-YER163C_CBS6413 | rna-NM_001179053.3_CBS6413 | cds-NP_011090.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:500856-501554:- | gene-YER163C_CENPK1137D | rna-NM_001179053.3_CENPK1137D | cds-NP_011090.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:490586-491284:- | gene-YER163C_EthanolRed | rna-NM_001179053.3_EthanolRed | cds-NP_011090.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:491522-492220:- | gene-YER163C_FaliES1 | rna-NM_001179053.3_FaliES1 | cds-NP_011090.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000169.1:47688-48386:+ | gene-YER163C_JAY291 | rna-NM_001179053.3_JAY291 | cds-NP_011090.3_JAY291 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:484687-485385:- | gene-YER163C_MUCL30387 | rna-NM_001179053.3_MUCL30387 | cds-NP_011090.3_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:487595-488293:- | gene-YER163C_MUCL30388 | rna-NM_001179053.3_MUCL30388 | cds-NP_011090.3_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:480404-481102:- | gene-YER163C_MUCL39482 | rna-NM_001179053.3_MUCL39482 | cds-NP_011090.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:494910-495608:- | gene-YER163C_MUCL42920 | rna-NM_001179053.3_MUCL42920 | cds-NP_011090.3_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:503083-503781:- | gene-YER163C_NCIM3186 | rna-NM_001179053.3_NCIM3186 | cds-NP_011090.3_NCIM3186 | 98.5 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:489861-490559:- | gene-YER163C_NCYC1407 | rna-NM_001179053.3_NCYC1407 | cds-NP_011090.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:505763-506461:- | gene-YER163C_PE2H3 | rna-NM_001179053.3_PE2H3 | cds-NP_011090.3_PE2H3 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:495704-496402:- | gene-YER163C_PE2H4 | rna-NM_001179053.3_PE2H4 | cds-NP_011090.3_PE2H4 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:503084-503782:- | gene-YER163C_S288C | rna-NM_001179053.3_S288C | cds-NP_011090.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000030.1:55249-55947:- | gene-YER163C_SA1 | rna-NM_001179053.3_SA1 | cds-NP_011090.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:492322-493020:- | gene-YER163C_ThermosaccDry | rna-NM_001179053.3_ThermosaccDry | cds-NP_011090.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:485609-486307:- | gene-YER163C_VR1 | rna-NM_001179053.3_VR1 | cds-NP_011090.3_VR1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000011.1:5175-5873:- | gene-YER163C_ZTW1 | rna-NM_001179053.3_ZTW1 | cds-NP_011090.3_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:493530-494228:- | gene-YER163C_Sparadoxus | rna-NM_001179053.3_Sparadoxus | cds-NP_011090.3_Sparadoxus | 88.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |