Gene name: GCD7
Reference locus (S288C): YLR291C
Gene biotype: protein_coding
Description: Beta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; human homolog EIF2B2 can complement yeast mutant, allows growth down-regulation of yeast gene; Belongs to the eIF-2B alpha/beta/delta subunits family
Top 10 interactors (score): SUI3 (0.999); GCD11 (0.999); GCD2 (0.999); SUI2 (0.999); GCD6 (0.999); GCD1 (0.999); GCN3 (0.999); GCN2 (0.973); YGL230C (0.909); RGP1 (0.9); RIC1 (0.9); URA7 (0.894); PSA1 (0.844); TIF5 (0.829); URA8 (0.814); EMC4 (0.808); MUK1 (0.778); CDD1 (0.769); CDC42 (0.762); GLT1 (0.752)
Homologues (species, bitscore): EIF2B2 (Homo sapiens, 174.9); Eif2b2 (Mus musculus, 176.4); eif2b2 (Danio rerio, 189.1); eif2b2 (Xenopus tropicalis, 179.5); eIF2B-beta (Drosophila melanogaster, 157.5); ZK1098.4 (Caenorhabditis elegans, 58.5); AT3G07300 (Arabidopsis thaliana, 197.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:667119-668264:- | gene-YLR291C_AKU4011 | rna-NM_001182179.1_AKU4011 | cds-NP_013394.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000170.1:64426-65571:+ | gene-YLR291C_BG1 | rna-NM_001182179.1_BG1 | cds-NP_013394.1_BG1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:702300-703445:- | gene-YLR291C_Bruggeman | rna-NM_001182179.1_Bruggeman | cds-NP_013394.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:700867-702012:- | gene-YLR291C_CAT1 | rna-NM_001182179.1_CAT1 | cds-NP_013394.1_CAT1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:702055-703200:- | gene-YLR291C_CBS1585 | rna-NM_001182179.1_CBS1585 | cds-NP_013394.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:686647-687792:- | gene-YLR291C_CBS436 | rna-NM_001182179.1_CBS436 | cds-NP_013394.1_CBS436 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:664688-665833:- | gene-YLR291C_CBS6412 | rna-NM_001182179.1_CBS6412 | cds-NP_013394.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:702720-703865:- | gene-YLR291C_CBS6413 | rna-NM_001182179.1_CBS6413 | cds-NP_013394.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:702914-704059:- | gene-YLR291C_CENPK1137D | rna-NM_001182179.1_CENPK1137D | cds-NP_013394.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:660398-661543:- | gene-YLR291C_EthanolRed | rna-NM_001182179.1_EthanolRed | cds-NP_013394.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:689598-690743:- | gene-YLR291C_FaliES1 | rna-NM_001182179.1_FaliES1 | cds-NP_013394.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000359.1:15030-16175:+ | gene-YLR291C_JAY291 | rna-NM_001182179.1_JAY291 | cds-NP_013394.1_JAY291 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:702191-703336:- | gene-YLR291C_MUCL30387 | rna-NM_001182179.1_MUCL30387 | cds-NP_013394.1_MUCL30387 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:707772-708917:- | gene-YLR291C_MUCL30388 | rna-NM_001182179.1_MUCL30388 | cds-NP_013394.1_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:703286-704431:- | gene-YLR291C_MUCL39482 | rna-NM_001182179.1_MUCL39482 | cds-NP_013394.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:698440-699585:- | gene-YLR291C_MUCL42920 | rna-NM_001182179.1_MUCL42920 | cds-NP_013394.1_MUCL42920 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:718291-719436:- | gene-YLR291C_NCIM3186 | rna-NM_001182179.1_NCIM3186 | cds-NP_013394.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:712617-713762:- | gene-YLR291C_NCYC1407 | rna-NM_001182179.1_NCYC1407 | cds-NP_013394.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:700412-701557:- | gene-YLR291C_PE2H3 | rna-NM_001182179.1_PE2H3 | cds-NP_013394.1_PE2H3 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:700156-701301:- | gene-YLR291C_PE2H4 | rna-NM_001182179.1_PE2H4 | cds-NP_013394.1_PE2H4 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:718317-719462:- | gene-YLR291C_S288C | rna-NM_001182179.1_S288C | cds-NP_013394.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000039.1:65225-66370:+ | gene-YLR291C_SA1 | rna-NM_001182179.1_SA1 | cds-NP_013394.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:691493-692638:- | gene-YLR291C_ThermosaccDry | rna-NM_001182179.1_ThermosaccDry | cds-NP_013394.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:703382-704527:- | gene-YLR291C_VR1 | rna-NM_001182179.1_VR1 | cds-NP_013394.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:29929-31074:- | gene-YLR291C_ZTW1 | rna-NM_001182179.1_ZTW1 | cds-NP_013394.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:677555-678700:- | gene-YLR291C_Sparadoxus | rna-NM_001182179.1_Sparadoxus | cds-NP_013394.1_Sparadoxus | 92.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |