Gene name: GCD6
Reference locus (S288C): YDR211W
Gene biotype: protein_coding
Description: Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress; Belongs to the eIF-2B gamma/epsilon subunits family
Top 10 interactors (score): GCD1 (0.999); SUI3 (0.999); GCN3 (0.999); GCD7 (0.999); SUI2 (0.999); GCD2 (0.999); GCD11 (0.999); TIF5 (0.995); GCN2 (0.952); SUI1 (0.919); RGP1 (0.901); RIC1 (0.9); URA7 (0.877); TIF4631 (0.832); PRT1 (0.795); HIS4 (0.771); TIF34 (0.76); GCN4 (0.753); IST1 (0.751); URA8 (0.744)
Homologues (species, bitscore): EIF2B5 (Homo sapiens, 306.2); Eif2b5 (Mus musculus, 312.8); eif2b5 (Danio rerio, 312.4); eif2b5 (Xenopus tropicalis, 328.2); CG3806 (Drosophila melanogaster, 233.4); D2085.3 (Caenorhabditis elegans, 157.1); AT2G34970 (Arabidopsis thaliana, 335.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:841373-843511:+ | gene-YDR211W_AKU4011 | rna-NM_001180519.3_AKU4011 | cds-NP_010497.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:282243-284381:- | gene-YDR211W_BG1 | rna-NM_001180519.3_BG1 | cds-NP_010497.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:873778-875916:+ | gene-YDR211W_Bruggeman | rna-NM_001180519.3_Bruggeman | cds-NP_010497.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:861043-863181:+ | gene-YDR211W_CAT1 | rna-NM_001180519.3_CAT1 | cds-NP_010497.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:831726-833864:+ | gene-YDR211W_CBS1585 | rna-NM_001180519.3_CBS1585 | cds-NP_010497.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:860792-862930:+ | gene-YDR211W_CBS436 | rna-NM_001180519.3_CBS436 | cds-NP_010497.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:828538-830676:+ | gene-YDR211W_CBS6412 | rna-NM_001180519.3_CBS6412 | cds-NP_010497.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:859083-861221:+ | gene-YDR211W_CBS6413 | rna-NM_001180519.3_CBS6413 | cds-NP_010497.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:883528-885666:+ | gene-YDR211W_CENPK1137D | rna-NM_001180519.3_CENPK1137D | cds-NP_010497.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:842112-844250:+ | gene-YDR211W_EthanolRed | rna-NM_001180519.3_EthanolRed | cds-NP_010497.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:850318-852456:+ | gene-YDR211W_FaliES1 | rna-NM_001180519.3_FaliES1 | cds-NP_010497.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000058.1:249-2387:+ | gene-YDR211W_JAY291 | rna-NM_001180519.3_JAY291 | cds-NP_010497.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:859429-861567:+ | gene-YDR211W_MUCL30387 | rna-NM_001180519.3_MUCL30387 | cds-NP_010497.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:847682-849820:+ | gene-YDR211W_MUCL30388 | rna-NM_001180519.3_MUCL30388 | cds-NP_010497.3_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:833178-835316:+ | gene-YDR211W_MUCL39482 | rna-NM_001180519.3_MUCL39482 | cds-NP_010497.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:772477-774615:+ | gene-YDR211W_MUCL42920 | rna-NM_001180519.3_MUCL42920 | cds-NP_010497.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:884650-886788:+ | gene-YDR211W_NCIM3186 | rna-NM_001180519.3_NCIM3186 | cds-NP_010497.3_NCIM3186 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:836864-839002:+ | gene-YDR211W_NCYC1407 | rna-NM_001180519.3_NCYC1407 | cds-NP_010497.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:853059-855197:+ | gene-YDR211W_PE2H3 | rna-NM_001180519.3_PE2H3 | cds-NP_010497.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:858340-860478:+ | gene-YDR211W_PE2H4 | rna-NM_001180519.3_PE2H4 | cds-NP_010497.3_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:884727-886865:+ | gene-YDR211W_S288C | rna-NM_001180519.3_S288C | cds-NP_010497.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000013.1:90825-92963:+ | gene-YDR211W_SA1 | rna-NM_001180519.3_SA1 | cds-NP_010497.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:848479-850617:+ | gene-YDR211W_ThermosaccDry | rna-NM_001180519.3_ThermosaccDry | cds-NP_010497.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:863705-865843:+ | gene-YDR211W_VR1 | rna-NM_001180519.3_VR1 | cds-NP_010497.3_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000007.1:111197-113335:+ | gene-YDR211W_ZTW1 | rna-NM_001180519.3_ZTW1 | cds-NP_010497.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:853620-855758:+ | gene-YDR211W_Sparadoxus | rna-NM_001180519.3_Sparadoxus | cds-NP_010497.3_Sparadoxus | 91.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |