Gene name: FZO1
Reference locus (S288C): YBR179C
Gene biotype: protein_coding
Description: Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily
Top 10 interactors (score): DNM1 (0.999); MGM1 (0.999); UGO1 (0.999); FIS1 (0.996); MDM30 (0.988); MDV1 (0.974); PCP1 (0.94); GEM1 (0.939); TIM23 (0.929); TOM20 (0.927); MDM10 (0.914); TOM40 (0.914); CAF4 (0.904); POR1 (0.889); CDC48 (0.883); UBP2 (0.868); TOM70 (0.867); OMA1 (0.834); MIC60 (0.823); MDM31 (0.821)
Homologues (species, bitscore): Marf (Drosophila melanogaster, 57.0); fzo-1 (Caenorhabditis elegans, 53.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:569419-571986:- | gene-YBR179C_AKU4011 | rna-NM_001178527.1_AKU4011 | cds-NP_009738.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:559903-562470:- | gene-YBR179C_BG1 | rna-NM_001178527.1_BG1 | cds-NP_009738.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:572443-575010:- | gene-YBR179C_Bruggeman | rna-NM_001178527.1_Bruggeman | cds-NP_009738.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:466530-469097:- | gene-YBR179C_CAT1 | rna-NM_001178527.1_CAT1 | cds-NP_009738.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:561200-563767:- | gene-YBR179C_CBS1585 | rna-NM_001178527.1_CBS1585 | cds-NP_009738.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:569256-571823:- | gene-YBR179C_CBS436 | rna-NM_001178527.1_CBS436 | cds-NP_009738.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:658685-661252:- | gene-YBR179C_CBS6412 | rna-NM_001178527.1_CBS6412 | cds-NP_009738.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:566756-569323:- | gene-YBR179C_CBS6413 | rna-NM_001178527.1_CBS6413 | cds-NP_009738.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:580344-582911:- | gene-YBR179C_CENPK1137D | rna-NM_001178527.1_CENPK1137D | cds-NP_009738.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:695260-697827:- | gene-YBR179C_EthanolRed | rna-NM_001178527.1_EthanolRed | cds-NP_009738.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:585492-588059:- | gene-YBR179C_FaliES1 | rna-NM_001178527.1_FaliES1 | cds-NP_009738.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000310.1:25301-27868:- | gene-YBR179C_JAY291 | rna-NM_001178527.1_JAY291 | cds-NP_009738.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:574074-576641:- | gene-YBR179C_MUCL30387 | rna-NM_001178527.1_MUCL30387 | cds-NP_009738.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:573382-575949:- | gene-YBR179C_MUCL30388 | rna-NM_001178527.1_MUCL30388 | cds-NP_009738.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:559573-562140:- | gene-YBR179C_MUCL39482 | rna-NM_001178527.1_MUCL39482 | cds-NP_009738.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:569498-572065:- | gene-YBR179C_MUCL42920 | rna-NM_001178527.1_MUCL42920 | cds-NP_009738.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:586344-588911:- | gene-YBR179C_NCIM3186 | rna-NM_001178527.1_NCIM3186 | cds-NP_009738.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:562143-564710:- | gene-YBR179C_NCYC1407 | rna-NM_001178527.1_NCYC1407 | cds-NP_009738.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:574775-577342:- | gene-YBR179C_PE2H3 | rna-NM_001178527.1_PE2H3 | cds-NP_009738.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:572451-575018:- | gene-YBR179C_PE2H4 | rna-NM_001178527.1_PE2H4 | cds-NP_009738.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:586547-589114:- | gene-YBR179C_S288C | rna-NM_001178527.1_S288C | cds-NP_009738.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000032.1:107766-110333:- | gene-YBR179C_SA1 | rna-NM_001178527.1_SA1 | cds-NP_009738.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:584502-587069:- | gene-YBR179C_ThermosaccDry | rna-NM_001178527.1_ThermosaccDry | cds-NP_009738.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:565926-568493:- | gene-YBR179C_VR1 | rna-NM_001178527.1_VR1 | cds-NP_009738.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:559618-562185:- | gene-YBR179C_ZTW1 | rna-NM_001178527.1_ZTW1 | cds-NP_009738.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:596966-599533:- | gene-YBR179C_Sparadoxus | rna-NM_001178527.1_Sparadoxus | cds-NP_009738.1_Sparadoxus | 89.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |