Gene name: FRD1
Reference locus (S288C): YEL047C
Gene biotype: protein_coding
Description: Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily
Top 10 interactors (score): SDH2 (0.885); PXA1 (0.847); KGD1 (0.844); SDH3 (0.813); MDH2 (0.803); ALT1 (0.798); FUM1 (0.794); OSM1 (0.781); SHH3 (0.754); CIR2 (0.726); IDP1 (0.718); LSC1 (0.716); LSC2 (0.71); YMR226C (0.703); YOL057W (0.697); CYT1 (0.696); FOX2 (0.688); SDH7 (0.682); ADH4 (0.659); ATP1 (0.655)
Homologues (species, bitscore): SDHA (Homo sapiens, 106.3); Sdha (Mus musculus, 108.2); sdha (Danio rerio, 104.0); sdha (Xenopus tropicalis, 65.1); SdhA (Drosophila melanogaster, 104.8); F48E8.3 (Caenorhabditis elegans, 297.7); SDH1-1 (Arabidopsis thaliana, 103.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:59445-60857:- | gene-YEL047C_AKU4011 | rna-NM_001178862.3_AKU4011 | cds-NP_010867.3_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000075.1:19691-21103:+ | gene-YEL047C_BG1 | rna-NM_001178862.3_BG1 | cds-NP_010867.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:62959-64371:- | gene-YEL047C_Bruggeman | rna-NM_001178862.3_Bruggeman | cds-NP_010867.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:61374-62786:- | gene-YEL047C_CAT1 | rna-NM_001178862.3_CAT1 | cds-NP_010867.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:59389-60801:- | gene-YEL047C_CBS1585 | rna-NM_001178862.3_CBS1585 | cds-NP_010867.3_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:61022-62434:- | gene-YEL047C_CBS436 | rna-NM_001178862.3_CBS436 | cds-NP_010867.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:59641-61053:- | gene-YEL047C_CBS6412 | rna-NM_001178862.3_CBS6412 | cds-NP_010867.3_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:64283-65695:- | gene-YEL047C_CBS6413 | rna-NM_001178862.3_CBS6413 | cds-NP_010867.3_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:63237-64649:- | gene-YEL047C_CENPK1137D | rna-NM_001178862.3_CENPK1137D | cds-NP_010867.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:59198-60610:- | gene-YEL047C_EthanolRed | rna-NM_001178862.3_EthanolRed | cds-NP_010867.3_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:59461-60873:- | gene-YEL047C_FaliES1 | rna-NM_001178862.3_FaliES1 | cds-NP_010867.3_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000022.1:18942-20354:+ | gene-YEL047C_JAY291 | rna-NM_001178862.3_JAY291 | cds-NP_010867.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:63643-65055:- | gene-YEL047C_MUCL30387 | rna-NM_001178862.3_MUCL30387 | cds-NP_010867.3_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:59503-60915:- | gene-YEL047C_MUCL30388 | rna-NM_001178862.3_MUCL30388 | cds-NP_010867.3_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:58760-60172:- | gene-YEL047C_MUCL39482 | rna-NM_001178862.3_MUCL39482 | cds-NP_010867.3_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:63393-64805:- | gene-YEL047C_MUCL42920 | rna-NM_001178862.3_MUCL42920 | cds-NP_010867.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:65384-66796:- | gene-YEL047C_NCIM3186 | rna-NM_001178862.3_NCIM3186 | cds-NP_010867.3_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:63854-65266:- | gene-YEL047C_NCYC1407 | rna-NM_001178862.3_NCYC1407 | cds-NP_010867.3_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:67879-69291:- | gene-YEL047C_PE2H3 | rna-NM_001178862.3_PE2H3 | cds-NP_010867.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:63794-65206:- | gene-YEL047C_PE2H4 | rna-NM_001178862.3_PE2H4 | cds-NP_010867.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:65385-66797:- | gene-YEL047C_S288C | rna-NM_001178862.3_S288C | cds-NP_010867.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000053.1:19787-21199:+ | gene-YEL047C_SA1 | rna-NM_001178862.3_SA1 | cds-NP_010867.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:59860-61272:- | gene-YEL047C_ThermosaccDry | rna-NM_001178862.3_ThermosaccDry | cds-NP_010867.3_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:59082-60494:- | gene-YEL047C_VR1 | rna-NM_001178862.3_VR1 | cds-NP_010867.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:58793-60205:- | gene-YEL047C_ZTW1 | rna-NM_001178862.3_ZTW1 | cds-NP_010867.3_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:61454-62866:- | gene-YEL047C_Sparadoxus | rna-NM_001178862.3_Sparadoxus | cds-NP_010867.3_Sparadoxus | 89.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |