Gene name: FPR4
Reference locus (S288C): YLR449W
Gene biotype: protein_coding
Description: FK506-binding protein 4; Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; contains a nucleoplasmin-like fold and can form pentamers; Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily
Top 10 interactors (score): FPR3 (0.999); NOP2 (0.997); RPF2 (0.996); ERB1 (0.995); EBP2 (0.994); NUG1 (0.992); NOP56 (0.992); BRX1 (0.992); PWP1 (0.989); NOP7 (0.989); RRB1 (0.989); NOC2 (0.989); HAS1 (0.985); RRS1 (0.98); NOP58 (0.978); NOP12 (0.978); NOG1 (0.976); PUF6 (0.974); NOP15 (0.971); RLP24 (0.968)
Homologues (species, bitscore): FKBP2 (Homo sapiens, 81.6); Fkbp2 (Mus musculus, 82.0); fkbp2 (Danio rerio, 82.0); Fkbp1a (Xenopus tropicalis, 81.6); FK506-bp1 (Drosophila melanogaster, 144.4); fkb-1 (Caenorhabditis elegans, 79.7); FKBP53 (Arabidopsis thaliana, 107.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:969106-970302:+ | gene-YLR449W_AKU4011 | rna-NM_001182337.3_AKU4011 | cds-NP_013554.3_AKU4011 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:201552-202739:+ | gene-YLR449W_BG1 | rna-NM_001182337.3_BG1 | cds-NP_013554.3_BG1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:1007417-1008595:+ | gene-YLR449W_Bruggeman | rna-NM_001182337.3_Bruggeman | cds-NP_013554.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:1003417-1004604:+ | gene-YLR449W_CAT1 | rna-NM_001182337.3_CAT1 | cds-NP_013554.3_CAT1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:1004696-1005892:+ | gene-YLR449W_CBS1585 | rna-NM_001182337.3_CBS1585 | cds-NP_013554.3_CBS1585 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:994040-995218:+ | gene-YLR449W_CBS436 | rna-NM_001182337.3_CBS436 | cds-NP_013554.3_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:1040743-1041921:+ | gene-YLR449W_CBS6412 | rna-NM_001182337.3_CBS6412 | cds-NP_013554.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:1005484-1006662:+ | gene-YLR449W_CBS6413 | rna-NM_001182337.3_CBS6413 | cds-NP_013554.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:1015440-1016618:+ | gene-YLR449W_CENPK1137D | rna-NM_001182337.3_CENPK1137D | cds-NP_013554.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:962128-963318:+ | gene-YLR449W_EthanolRed | rna-NM_001182337.3_EthanolRed | cds-NP_013554.3_EthanolRed | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:997399-998589:+ | gene-YLR449W_FaliES1 | rna-NM_001182337.3_FaliES1 | cds-NP_013554.3_FaliES1 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000194.1:20087-21274:- | gene-YLR449W_JAY291 | rna-NM_001182337.3_JAY291 | cds-NP_013554.3_JAY291 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:1006272-1007453:+ | gene-YLR449W_MUCL30387 | rna-NM_001182337.3_MUCL30387 | cds-NP_013554.3_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:1016105-1017286:+ | gene-YLR449W_MUCL30388 | rna-NM_001182337.3_MUCL30388 | cds-NP_013554.3_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:1005930-1007126:+ | gene-YLR449W_MUCL39482 | rna-NM_001182337.3_MUCL39482 | cds-NP_013554.3_MUCL39482 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:1006396-1007577:+ | gene-YLR449W_MUCL42920 | rna-NM_001182337.3_MUCL42920 | cds-NP_013554.3_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:1030808-1031986:+ | gene-YLR449W_NCIM3186 | rna-NM_001182337.3_NCIM3186 | cds-NP_013554.3_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:1015349-1016563:+ | gene-YLR449W_NCYC1407 | rna-NM_001182337.3_NCYC1407 | cds-NP_013554.3_NCYC1407 | 96.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:1001821-1003008:+ | gene-YLR449W_PE2H3 | rna-NM_001182337.3_PE2H3 | cds-NP_013554.3_PE2H3 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:1001565-1002752:+ | gene-YLR449W_PE2H4 | rna-NM_001182337.3_PE2H4 | cds-NP_013554.3_PE2H4 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:1030834-1032012:+ | gene-YLR449W_S288C | rna-NM_001182337.3_S288C | cds-NP_013554.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:27850-29037:- | gene-YLR449W_SA1 | rna-NM_001182337.3_SA1 | cds-NP_013554.3_SA1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:1000477-1001667:+ | gene-YLR449W_ThermosaccDry | rna-NM_001182337.3_ThermosaccDry | cds-NP_013554.3_ThermosaccDry | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:1006902-1008089:+ | gene-YLR449W_VR1 | rna-NM_001182337.3_VR1 | cds-NP_013554.3_VR1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:330740-331921:+ | gene-YLR449W_ZTW1 | rna-NM_001182337.3_ZTW1 | cds-NP_013554.3_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:979684-980868:+ | gene-YLR449W_Sparadoxus | rna-NM_001182337.3_Sparadoxus | cds-NP_013554.3_Sparadoxus | 88.8 | 98.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |