Gene name: FPK1
Reference locus (S288C): YNR047W
Gene biotype: protein_coding
Description: Flippase kinase 1; Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments and thplasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; FPK1 has a paralog, KIN82, that arose from the whole genome duplication
Top 10 interactors (score): DNF1 (0.978); DNF2 (0.96); DNF3 (0.91); YPK1 (0.834); ORM1 (0.803); LEM3 (0.773); ORM2 (0.724); NEO1 (0.712); KIN82 (0.698); SLM1 (0.677); AKL1 (0.631); DRS2 (0.623); CDC50 (0.619); YTA6 (0.607); LCB4 (0.589); CDC42 (0.584); DPH6 (0.547); GIN4 (0.523); MDS3 (0.519); RHO1 (0.515)
Homologues (species, bitscore): RPS6KB1 (Homo sapiens, 247.7); Rps6kb1 (Mus musculus, 247.7); rps6kb1b (Danio rerio, 241.5); rps6kb1 (Xenopus tropicalis, 247.7); S6kII (Drosophila melanogaster, 238.4); rskn-1 (Caenorhabditis elegans, 246.5); PHOT2 (Arabidopsis thaliana, 312.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:240291-242972:- | gene-YNR047W_AKU4011 | rna-NM_001183224.1_AKU4011 | cds-NP_014445.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:600063-602744:+ | gene-YNR047W_BG1 | rna-NM_001183224.1_BG1 | cds-NP_014445.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:709843-712524:+ | gene-YNR047W_Bruggeman | rna-NM_001183224.1_Bruggeman | cds-NP_014445.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:743814-746495:+ | gene-YNR047W_CAT1 | rna-NM_001183224.1_CAT1 | cds-NP_014445.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:698065-700746:+ | gene-YNR047W_CBS1585 | rna-NM_001183224.1_CBS1585 | cds-NP_014445.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:759607-762288:+ | gene-YNR047W_CBS436 | rna-NM_001183224.1_CBS436 | cds-NP_014445.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:687043-689724:+ | gene-YNR047W_CBS6412 | rna-NM_001183224.1_CBS6412 | cds-NP_014445.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:688728-691409:+ | gene-YNR047W_CBS6413 | rna-NM_001183224.1_CBS6413 | cds-NP_014445.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:702267-704948:+ | gene-YNR047W_CENPK1137D | rna-NM_001183224.1_CENPK1137D | cds-NP_014445.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:693707-696388:+ | gene-YNR047W_EthanolRed | rna-NM_001183224.1_EthanolRed | cds-NP_014445.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:684910-687591:+ | gene-YNR047W_FaliES1 | rna-NM_001183224.1_FaliES1 | cds-NP_014445.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000037.1:15049-17730:- | gene-YNR047W_JAY291 | rna-NM_001183224.1_JAY291 | cds-NP_014445.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:707771-710452:+ | gene-YNR047W_MUCL30387 | rna-NM_001183224.1_MUCL30387 | cds-NP_014445.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:748831-751512:+ | gene-YNR047W_MUCL30388 | rna-NM_001183224.1_MUCL30388 | cds-NP_014445.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:689534-692215:+ | gene-YNR047W_MUCL39482 | rna-NM_001183224.1_MUCL39482 | cds-NP_014445.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:694244-696925:+ | gene-YNR047W_MUCL42920 | rna-NM_001183224.1_MUCL42920 | cds-NP_014445.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:708492-711173:+ | gene-YNR047W_NCIM3186 | rna-NM_001183224.1_NCIM3186 | cds-NP_014445.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:692052-694733:+ | gene-YNR047W_NCYC1407 | rna-NM_001183224.1_NCYC1407 | cds-NP_014445.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:692915-695596:+ | gene-YNR047W_PE2H3 | rna-NM_001183224.1_PE2H3 | cds-NP_014445.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:694317-696998:+ | gene-YNR047W_PE2H4 | rna-NM_001183224.1_PE2H4 | cds-NP_014445.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:708523-711204:+ | gene-YNR047W_S288C | rna-NM_001183224.1_S288C | cds-NP_014445.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000074.1:15113-17794:- | gene-YNR047W_SA1 | rna-NM_001183224.1_SA1 | cds-NP_014445.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:685247-687928:+ | gene-YNR047W_ThermosaccDry | rna-NM_001183224.1_ThermosaccDry | cds-NP_014445.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:727376-730057:+ | gene-YNR047W_VR1 | rna-NM_001183224.1_VR1 | cds-NP_014445.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:595025-597706:+ | gene-YNR047W_ZTW1 | rna-NM_001183224.1_ZTW1 | cds-NP_014445.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:699474-702158:+ | gene-YNR047W_Sparadoxus | rna-NM_001183224.1_Sparadoxus | cds-NP_014445.1_Sparadoxus | 89.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |