Gene name: FOL2
Reference locus (S288C): YGR267C
Gene biotype: protein_coding
Description: GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant
Top 10 interactors (score): RIB1 (0.978); DFR1 (0.966); FOL3 (0.964); FOL1 (0.948); SHM1 (0.904); PHO8 (0.9); ABZ1 (0.894); RMA1 (0.888); HAM1 (0.869); YNK1 (0.862); FAU1 (0.86); MET7 (0.851); CDC19 (0.848); YGR269W (0.846); PYK2 (0.829); MIS1 (0.815); CYR1 (0.804); YND1 (0.802); MET12 (0.797); ADE8 (0.792)
Homologues (species, bitscore): GCH1 (Homo sapiens, 258.1); Gch1 (Mus musculus, 258.1); gch2 (Danio rerio, 261.5); gch1 (Xenopus tropicalis, 260.0); Pu (Drosophila melanogaster, 236.5); cat-4 (Caenorhabditis elegans, 261.9); AT3G07270 (Arabidopsis thaliana, 126.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:990436-991167:- | gene-YGR267C_AKU4011 | rna-NM_001181396.1_AKU4011 | cds-NP_011783.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:270439-271170:- | gene-YGR267C_BG1 | rna-NM_001181396.1_BG1 | cds-NP_011783.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:998954-999685:- | gene-YGR267C_Bruggeman | rna-NM_001181396.1_Bruggeman | cds-NP_011783.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:998145-998876:- | gene-YGR267C_CAT1 | rna-NM_001181396.1_CAT1 | cds-NP_011783.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:993306-994037:- | gene-YGR267C_CBS1585 | rna-NM_001181396.1_CBS1585 | cds-NP_011783.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:996932-997663:- | gene-YGR267C_CBS436 | rna-NM_001181396.1_CBS436 | cds-NP_011783.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:984196-984927:- | gene-YGR267C_CBS6412 | rna-NM_001181396.1_CBS6412 | cds-NP_011783.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:990251-990982:- | gene-YGR267C_CBS6413 | rna-NM_001181396.1_CBS6413 | cds-NP_011783.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:1024674-1025405:- | gene-YGR267C_CENPK1137D | rna-NM_001181396.1_CENPK1137D | cds-NP_011783.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:978285-979016:- | gene-YGR267C_EthanolRed | rna-NM_001181396.1_EthanolRed | cds-NP_011783.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:983091-983822:- | gene-YGR267C_FaliES1 | rna-NM_001181396.1_FaliES1 | cds-NP_011783.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000076.1:46493-47224:+ | gene-YGR267C_JAY291 | rna-NM_001181396.1_JAY291 | cds-NP_011783.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:996694-997425:- | gene-YGR267C_MUCL30387 | rna-NM_001181396.1_MUCL30387 | cds-NP_011783.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:994827-995558:- | gene-YGR267C_MUCL30388 | rna-NM_001181396.1_MUCL30388 | cds-NP_011783.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:988412-989143:- | gene-YGR267C_MUCL39482 | rna-NM_001181396.1_MUCL39482 | cds-NP_011783.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:1006280-1007011:- | gene-YGR267C_MUCL42920 | rna-NM_001181396.1_MUCL42920 | cds-NP_011783.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:1025004-1025735:- | gene-YGR267C_NCIM3186 | rna-NM_001181396.1_NCIM3186 | cds-NP_011783.1_NCIM3186 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:984041-984772:- | gene-YGR267C_NCYC1407 | rna-NM_001181396.1_NCYC1407 | cds-NP_011783.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:1009232-1009963:- | gene-YGR267C_PE2H3 | rna-NM_001181396.1_PE2H3 | cds-NP_011783.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:1014071-1014802:- | gene-YGR267C_PE2H4 | rna-NM_001181396.1_PE2H4 | cds-NP_011783.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:1025004-1025735:- | gene-YGR267C_S288C | rna-NM_001181396.1_S288C | cds-NP_011783.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000063.1:23223-23954:- | gene-YGR267C_SA1 | rna-NM_001181396.1_SA1 | cds-NP_011783.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:1003611-1004342:- | gene-YGR267C_ThermosaccDry | rna-NM_001181396.1_ThermosaccDry | cds-NP_011783.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:1109392-1110123:- | gene-YGR267C_VR1 | rna-NM_001181396.1_VR1 | cds-NP_011783.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:305021-305752:- | gene-YGR267C_ZTW1 | rna-NM_001181396.1_ZTW1 | cds-NP_011783.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:995651-996382:- | gene-YGR267C_Sparadoxus | rna-NM_001181396.1_Sparadoxus | cds-NP_011783.1_Sparadoxus | 93.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |