Gene name: FKH2
Reference locus (S288C): YNL068C
Gene biotype: protein_coding
Description: Fork head protein homolog 2; Forkhead family transcription factor; rate-limiting activator of replication origins; evolutionarily conserved regulator of lifespan; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; positively regulates transcriptional elongation; facilitates clustering, activation of early-firing replication origins; negative role in chromatin silencing at HML and HMR; major role in expression of G2/M phase genes; relocalizes to cytosol under hypoxia
Top 10 interactors (score): MCM1 (0.999); NDD1 (0.998); SWI5 (0.987); CLB2 (0.976); ACE2 (0.97); CDC28 (0.953); SWI4 (0.951); YOX1 (0.942); SWI6 (0.931); MBP1 (0.925); FKH1 (0.891); CLB5 (0.87); YHP1 (0.852); CLB1 (0.852); CDC20 (0.826); CDC5 (0.784); HIR2 (0.774); CLB6 (0.769); CLN3 (0.766); MPH1 (0.764)
Homologues (species, bitscore): FOXJ1 (Homo sapiens, 113.2); Foxj1 (Mus musculus, 113.2); foxj1b (Danio rerio, 117.1); foxj1 (Xenopus tropicalis, 112.5); slp2 (Drosophila melanogaster, 109.0); fkh-2 (Caenorhabditis elegans, 110.2); FHA2 (Arabidopsis thaliana, 58.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:489381-491969:- | gene-YNL068C_AKU4011 | rna-NM_001182906.3_AKU4011 | cds-NP_014331.3_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:393395-395983:- | gene-YNL068C_BG1 | rna-NM_001182906.3_BG1 | cds-NP_014331.3_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:500108-502696:- | gene-YNL068C_Bruggeman | rna-NM_001182906.3_Bruggeman | cds-NP_014331.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:543102-545690:- | gene-YNL068C_CAT1 | rna-NM_001182906.3_CAT1 | cds-NP_014331.3_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:490049-492637:- | gene-YNL068C_CBS1585 | rna-NM_001182906.3_CBS1585 | cds-NP_014331.3_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:558464-561052:- | gene-YNL068C_CBS436 | rna-NM_001182906.3_CBS436 | cds-NP_014331.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:485143-487731:- | gene-YNL068C_CBS6412 | rna-NM_001182906.3_CBS6412 | cds-NP_014331.3_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:486459-489047:- | gene-YNL068C_CBS6413 | rna-NM_001182906.3_CBS6413 | cds-NP_014331.3_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:489562-492182:- | gene-YNL068C_CENPK1137D | rna-NM_001182906.3_CENPK1137D | cds-NP_014331.3_CENPK1137D | 96.9 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:492199-494787:- | gene-YNL068C_EthanolRed | rna-NM_001182906.3_EthanolRed | cds-NP_014331.3_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:482724-485312:- | gene-YNL068C_FaliES1 | rna-NM_001182906.3_FaliES1 | cds-NP_014331.3_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000001.1:9165-11180:- | gene-YNL068C_JAY291 | rna-NM_001182906.3_JAY291 | cds-NP_014331.3_JAY291 | 77.4 | 77.8 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:496270-498858:- | gene-YNL068C_MUCL30387 | rna-NM_001182906.3_MUCL30387 | cds-NP_014331.3_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:531670-534258:- | gene-YNL068C_MUCL30388 | rna-NM_001182906.3_MUCL30388 | cds-NP_014331.3_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:487451-490039:- | gene-YNL068C_MUCL39482 | rna-NM_001182906.3_MUCL39482 | cds-NP_014331.3_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:491371-493959:- | gene-YNL068C_MUCL42920 | rna-NM_001182906.3_MUCL42920 | cds-NP_014331.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:495670-498258:- | gene-YNL068C_NCIM3186 | rna-NM_001182906.3_NCIM3186 | cds-NP_014331.3_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:489503-492091:- | gene-YNL068C_NCYC1407 | rna-NM_001182906.3_NCYC1407 | cds-NP_014331.3_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:492742-495330:- | gene-YNL068C_PE2H3 | rna-NM_001182906.3_PE2H3 | cds-NP_014331.3_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:487817-490405:- | gene-YNL068C_PE2H4 | rna-NM_001182906.3_PE2H4 | cds-NP_014331.3_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:495701-498289:- | gene-YNL068C_S288C | rna-NM_001182906.3_S288C | cds-NP_014331.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000024.1:80661-83249:- | gene-YNL068C_SA1 | rna-NM_001182906.3_SA1 | cds-NP_014331.3_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:483599-486187:- | gene-YNL068C_ThermosaccDry | rna-NM_001182906.3_ThermosaccDry | cds-NP_014331.3_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:502706-505294:- | gene-YNL068C_VR1 | rna-NM_001182906.3_VR1 | cds-NP_014331.3_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:392947-395535:- | gene-YNL068C_ZTW1 | rna-NM_001182906.3_ZTW1 | cds-NP_014331.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:499143-501716:- | gene-YNL068C_Sparadoxus | rna-NM_001182906.3_Sparadoxus | cds-NP_014331.3_Sparadoxus | 89.1 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |