Gene name: FKH1
Reference locus (S288C): YIL131C
Gene biotype: protein_coding
Description: Fork head protein homolog 1; Forkhead family transcription factor; rate-limiting replication origin activator; evolutionarily conserved lifespan regulator; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; regulates transcription elongation, chromatin silencing at mating loci, expression of G2/M phase genes; facilitates clustering, activation of early-firing replication origins; binds HML recombination enhancer, regulates donor preference during mating-type switching
Top 10 interactors (score): MCM1 (0.994); NDD1 (0.989); SWI5 (0.974); CLB2 (0.967); ACE2 (0.942); MBP1 (0.929); SWI4 (0.926); CDC28 (0.924); SWI6 (0.92); HRD3 (0.92); DER1 (0.918); YHP1 (0.903); FKH2 (0.891); YOX1 (0.855); CLB1 (0.819); CLB5 (0.775); SKN7 (0.772); REB1 (0.738); SIR2 (0.728); CDC20 (0.723)
Homologues (species, bitscore): FOXJ1 (Homo sapiens, 98.6); Foxi2 (Mus musculus, 99.4); foxj1a (Danio rerio, 104.4); foxk2 (Xenopus tropicalis, 99.0); fd96Ca (Drosophila melanogaster, 94.0); fkh-2 (Caenorhabditis elegans, 93.6); FHA2 (Arabidopsis thaliana, 56.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005303.1:101997-103451:- | gene-YIL131C_AKU4011 | rna-NM_001179479.1_AKU4011 | cds-NP_012135.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000174.1:33910-35364:+ | gene-YIL131C_BG1 | rna-NM_001179479.1_BG1 | cds-NP_012135.1_BG1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005511.1:104755-106209:- | gene-YIL131C_Bruggeman | rna-NM_001179479.1_Bruggeman | cds-NP_012135.1_Bruggeman | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005527.1:98568-100022:- | gene-YIL131C_CAT1 | rna-NM_001179479.1_CAT1 | cds-NP_012135.1_CAT1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005367.1:102199-103653:- | gene-YIL131C_CBS1585 | rna-NM_001179479.1_CBS1585 | cds-NP_012135.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005351.1:93338-94792:- | gene-YIL131C_CBS436 | rna-NM_001179479.1_CBS436 | cds-NP_012135.1_CBS436 | 98.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005335.1:99729-101183:- | gene-YIL131C_CBS6412 | rna-NM_001179479.1_CBS6412 | cds-NP_012135.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005319.1:93885-95339:- | gene-YIL131C_CBS6413 | rna-NM_001179479.1_CBS6413 | cds-NP_012135.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001530.1:92486-93940:- | gene-YIL131C_CENPK1137D | rna-NM_001179479.1_CENPK1137D | cds-NP_012135.1_CENPK1137D | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005479.1:87533-88987:- | gene-YIL131C_EthanolRed | rna-NM_001179479.1_EthanolRed | cds-NP_012135.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005543.1:103336-104790:- | gene-YIL131C_FaliES1 | rna-NM_001179479.1_FaliES1 | cds-NP_012135.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000319.1:3563-5017:+ | gene-YIL131C_JAY291 | rna-NM_001179479.1_JAY291 | cds-NP_012135.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005415.1:102514-103968:- | gene-YIL131C_MUCL30387 | rna-NM_001179479.1_MUCL30387 | cds-NP_012135.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005447.1:102194-103648:- | gene-YIL131C_MUCL30388 | rna-NM_001179479.1_MUCL30388 | cds-NP_012135.1_MUCL30388 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005287.1:103127-104581:- | gene-YIL131C_MUCL39482 | rna-NM_001179479.1_MUCL39482 | cds-NP_012135.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005431.1:106326-107780:- | gene-YIL131C_MUCL42920 | rna-NM_001179479.1_MUCL42920 | cds-NP_012135.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011818.1:100781-102235:- | gene-YIL131C_NCIM3186 | rna-NM_001179479.1_NCIM3186 | cds-NP_012135.1_NCIM3186 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005271.1:107091-108545:- | gene-YIL131C_NCYC1407 | rna-NM_001179479.1_NCYC1407 | cds-NP_012135.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994148.1:101715-103169:- | gene-YIL131C_PE2H3 | rna-NM_001179479.1_PE2H3 | cds-NP_012135.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999880.1:95678-97132:- | gene-YIL131C_PE2H4 | rna-NM_001179479.1_PE2H4 | cds-NP_012135.1_PE2H4 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001141.2:100781-102235:- | gene-YIL131C_S288C | rna-NM_001179479.1_S288C | cds-NP_012135.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000050.1:79355-80809:- | gene-YIL131C_SA1 | rna-NM_001179479.1_SA1 | cds-NP_012135.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005495.1:101946-103400:- | gene-YIL131C_ThermosaccDry | rna-NM_001179479.1_ThermosaccDry | cds-NP_012135.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005463.1:99105-100559:- | gene-YIL131C_VR1 | rna-NM_001179479.1_VR1 | cds-NP_012135.1_VR1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000019.1:76927-78381:- | gene-YIL131C_ZTW1 | rna-NM_001179479.1_ZTW1 | cds-NP_012135.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047495.1:94773-96224:- | gene-YIL131C_Sparadoxus | rna-NM_001179479.1_Sparadoxus | cds-NP_012135.1_Sparadoxus | 90.5 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |