Gene name: FIG4
Reference locus (S288C): YNL325C
Gene biotype: protein_coding
Description: Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder
Top 10 interactors (score): VAC14 (0.999); FAB1 (0.999); VAC7 (0.997); ATG18 (0.996); YMR1 (0.989); VPS34 (0.98); VPS30 (0.945); INP54 (0.92); VPS15 (0.913); VPS38 (0.905); ATG38 (0.903); ATG14 (0.9); PIK1 (0.809); SEC14 (0.698); YNL324W (0.697); VPS33 (0.693); VAM6 (0.688); VPS3 (0.686); VPS16 (0.661); YPT7 (0.658)
Homologues (species, bitscore): FIG4 (Homo sapiens, 513.5); Fig4 (Mus musculus, 515.8); fig4a (Danio rerio, 224.2); Fig4 (Xenopus tropicalis, 259.6); CG17840 (Drosophila melanogaster, 439.1); C34B7.2 (Caenorhabditis elegans, 394.8); ATSAC1 (Arabidopsis thaliana, 403.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:22541-25180:- | gene-YNL325C_AKU4011 | rna-NM_001183163.1_AKU4011 | cds-NP_014074.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000074.1:65463-68108:+ | gene-YNL325C_BG1 | rna-NM_001183163.1_BG1 | cds-NP_014074.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:31629-34274:- | gene-YNL325C_Bruggeman | rna-NM_001183163.1_Bruggeman | cds-NP_014074.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:34257-36902:- | gene-YNL325C_CAT1 | rna-NM_001183163.1_CAT1 | cds-NP_014074.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:22875-25514:- | gene-YNL325C_CBS1585 | rna-NM_001183163.1_CBS1585 | cds-NP_014074.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:23367-26012:- | gene-YNL325C_CBS436 | rna-NM_001183163.1_CBS436 | cds-NP_014074.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:19532-22171:- | gene-YNL325C_CBS6412 | rna-NM_001183163.1_CBS6412 | cds-NP_014074.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:19721-22360:- | gene-YNL325C_CBS6413 | rna-NM_001183163.1_CBS6413 | cds-NP_014074.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:22567-25206:- | gene-YNL325C_CENPK1137D | rna-NM_001183163.1_CENPK1137D | cds-NP_014074.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:19567-22206:- | gene-YNL325C_EthanolRed | rna-NM_001183163.1_EthanolRed | cds-NP_014074.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:20466-23105:- | gene-YNL325C_FaliES1 | rna-NM_001183163.1_FaliES1 | cds-NP_014074.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000390.1:32421-35066:+ | gene-YNL325C_JAY291 | rna-NM_001183163.1_JAY291 | cds-NP_014074.1_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:31912-34557:- | gene-YNL325C_MUCL30387 | rna-NM_001183163.1_MUCL30387 | cds-NP_014074.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:25164-27809:- | gene-YNL325C_MUCL30388 | rna-NM_001183163.1_MUCL30388 | cds-NP_014074.1_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:20507-23146:- | gene-YNL325C_MUCL39482 | rna-NM_001183163.1_MUCL39482 | cds-NP_014074.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:22197-24842:- | gene-YNL325C_MUCL42920 | rna-NM_001183163.1_MUCL42920 | cds-NP_014074.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:28708-31347:- | gene-YNL325C_NCIM3186 | rna-NM_001183163.1_NCIM3186 | cds-NP_014074.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:21841-24480:- | gene-YNL325C_NCYC1407 | rna-NM_001183163.1_NCYC1407 | cds-NP_014074.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:19032-21677:- | gene-YNL325C_PE2H3 | rna-NM_001183163.1_PE2H3 | cds-NP_014074.1_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:18420-21065:- | gene-YNL325C_PE2H4 | rna-NM_001183163.1_PE2H4 | cds-NP_014074.1_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:28739-31378:- | gene-YNL325C_S288C | rna-NM_001183163.1_S288C | cds-NP_014074.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000052.1:65837-68482:+ | gene-YNL325C_SA1 | rna-NM_001183163.1_SA1 | cds-NP_014074.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:21323-23962:- | gene-YNL325C_ThermosaccDry | rna-NM_001183163.1_ThermosaccDry | cds-NP_014074.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:33858-36503:- | gene-YNL325C_VR1 | rna-NM_001183163.1_VR1 | cds-NP_014074.1_VR1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000029.1:12532-15171:- | gene-YNL325C_ZTW1 | rna-NM_001183163.1_ZTW1 | cds-NP_014074.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:30482-33121:- | gene-YNL325C_Sparadoxus | rna-NM_001183163.1_Sparadoxus | cds-NP_014074.1_Sparadoxus | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |