Gene name: FHL1
Reference locus (S288C): YPR104C
Gene biotype: protein_coding
Description: Pre-rRNA-processing protein FHL1; Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
Top 10 interactors (score): IFH1 (0.998); RAP1 (0.979); ABF1 (0.96); SFP1 (0.929); MCM1 (0.878); HMO1 (0.835); GCN4 (0.824); SWI5 (0.815); MSN2 (0.815); SWI4 (0.813); MBP1 (0.804); SCH9 (0.801); MET32 (0.785); SWI6 (0.782); NDD1 (0.781); ACE2 (0.778); STB3 (0.762); MSN4 (0.746); YAP5 (0.745); CBF1 (0.739)
Homologues (species, bitscore): FOXK1 (Homo sapiens, 95.5); Foxk1 (Mus musculus, 97.1); foxk1 (Danio rerio, 101.3); foxk2 (Xenopus tropicalis, 92.4); FoxN (Drosophila melanogaster, 79.7); pha-4 (Caenorhabditis elegans, 83.2); AT3G07260 (Arabidopsis thaliana, 77.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:705459-708269:- | gene-YPR104C_AKU4011 | rna-NM_001184201.1_AKU4011 | cds-NP_015429.1_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:189574-192384:+ | gene-YPR104C_BG1 | rna-NM_001184201.1_BG1 | cds-NP_015429.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:783468-786278:- | gene-YPR104C_Bruggeman | rna-NM_001184201.1_Bruggeman | cds-NP_015429.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:827768-830578:- | gene-YPR104C_CAT1 | rna-NM_001184201.1_CAT1 | cds-NP_015429.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:709716-712526:- | gene-YPR104C_CBS1585 | rna-NM_001184201.1_CBS1585 | cds-NP_015429.1_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:724010-726820:- | gene-YPR104C_CBS436 | rna-NM_001184201.1_CBS436 | cds-NP_015429.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:711952-714762:- | gene-YPR104C_CBS6412 | rna-NM_001184201.1_CBS6412 | cds-NP_015429.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:706673-709483:- | gene-YPR104C_CBS6413 | rna-NM_001184201.1_CBS6413 | cds-NP_015429.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:733601-736418:- | gene-YPR104C_CENPK1137D | rna-NM_001184201.1_CENPK1137D | cds-NP_015429.1_CENPK1137D | 99.6 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:1032073-1034883:- | gene-YPR104C_EthanolRed | rna-NM_001184201.1_EthanolRed | cds-NP_015429.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:711620-714430:- | gene-YPR104C_FaliES1 | rna-NM_001184201.1_FaliES1 | cds-NP_015429.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000436.1:2379-5189:- | gene-YPR104C_JAY291 | rna-NM_001184201.1_JAY291 | cds-NP_015429.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:724726-727536:- | gene-YPR104C_MUCL30387 | rna-NM_001184201.1_MUCL30387 | cds-NP_015429.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:723416-726226:- | gene-YPR104C_MUCL30388 | rna-NM_001184201.1_MUCL30388 | cds-NP_015429.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:702223-705033:- | gene-YPR104C_MUCL39482 | rna-NM_001184201.1_MUCL39482 | cds-NP_015429.1_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:765318-768128:- | gene-YPR104C_MUCL42920 | rna-NM_001184201.1_MUCL42920 | cds-NP_015429.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:733606-736416:- | gene-YPR104C_NCIM3186 | rna-NM_001184201.1_NCIM3186 | cds-NP_015429.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:710817-713627:- | gene-YPR104C_NCYC1407 | rna-NM_001184201.1_NCYC1407 | cds-NP_015429.1_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:717054-719864:- | gene-YPR104C_PE2H3 | rna-NM_001184201.1_PE2H3 | cds-NP_015429.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:716702-719512:- | gene-YPR104C_PE2H4 | rna-NM_001184201.1_PE2H4 | cds-NP_015429.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:733623-736433:- | gene-YPR104C_S288C | rna-NM_001184201.1_S288C | cds-NP_015429.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000028.1:31742-34552:- | gene-YPR104C_SA1 | rna-NM_001184201.1_SA1 | cds-NP_015429.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:711065-713875:- | gene-YPR104C_ThermosaccDry | rna-NM_001184201.1_ThermosaccDry | cds-NP_015429.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:727721-730531:- | gene-YPR104C_VR1 | rna-NM_001184201.1_VR1 | cds-NP_015429.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:710115-712925:- | gene-YPR104C_ZTW1 | rna-NM_001184201.1_ZTW1 | cds-NP_015429.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:711060-713857:- | gene-YPR104C_Sparadoxus | rna-NM_001184201.1_Sparadoxus | cds-NP_015429.1_Sparadoxus | 87.4 | 99.5 | Verified | 1 | 1 | 0 | False | False | False | True | False |