Gene name: FAA4
Reference locus (S288C): YMR246W
Gene biotype: protein_coding
Description: Long-chain-fatty-acid--CoA ligase 4; Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; role in stationary phase survival; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4; Belongs to the ATP-dependent AMP-binding enzyme family
Top 10 interactors (score): POX1 (0.984); FAT1 (0.971); FAS2 (0.971); FAS1 (0.969); FAA1 (0.966); OLE1 (0.936); YJU3 (0.885); TGL3 (0.885); INA1 (0.88); TGL5 (0.808); DGA1 (0.789); FAA2 (0.788); PXA1 (0.78); TGL4 (0.748); TGL1 (0.743); LRO1 (0.72); TES1 (0.712); FOX2 (0.702); ARE2 (0.686); ATG15 (0.684)
Homologues (species, bitscore): ACSL4 (Homo sapiens, 317.8); Acsl4 (Mus musculus, 321.6); acsl3b (Danio rerio, 315.8); acsl4 (Xenopus tropicalis, 290.0); Acsl (Drosophila melanogaster, 341.3); acs-17 (Caenorhabditis elegans, 329.3); LACS8 (Arabidopsis thaliana, 318.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:799674-801758:+ | gene-YMR246W_AKU4011 | rna-NM_001182754.1_AKU4011 | cds-NP_013974.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:152794-154878:- | gene-YMR246W_BG1 | rna-NM_001182754.1_BG1 | cds-NP_013974.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:743909-745993:+ | gene-YMR246W_Bruggeman | rna-NM_001182754.1_Bruggeman | cds-NP_013974.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:747833-749917:+ | gene-YMR246W_CAT1 | rna-NM_001182754.1_CAT1 | cds-NP_013974.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:731934-734018:+ | gene-YMR246W_CBS1585 | rna-NM_001182754.1_CBS1585 | cds-NP_013974.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:736212-738296:+ | gene-YMR246W_CBS436 | rna-NM_001182754.1_CBS436 | cds-NP_013974.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:843491-845575:+ | gene-YMR246W_CBS6412 | rna-NM_001182754.1_CBS6412 | cds-NP_013974.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:731085-733169:+ | gene-YMR246W_CBS6413 | rna-NM_001182754.1_CBS6413 | cds-NP_013974.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:754536-756620:+ | gene-YMR246W_CENPK1137D | rna-NM_001182754.1_CENPK1137D | cds-NP_013974.1_CENPK1137D | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:792334-794418:+ | gene-YMR246W_EthanolRed | rna-NM_001182754.1_EthanolRed | cds-NP_013974.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:738359-740443:+ | gene-YMR246W_FaliES1 | rna-NM_001182754.1_FaliES1 | cds-NP_013974.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000141.1:46132-48216:- | gene-YMR246W_JAY291 | rna-NM_001182754.1_JAY291 | cds-NP_013974.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:737692-739776:+ | gene-YMR246W_MUCL30387 | rna-NM_001182754.1_MUCL30387 | cds-NP_013974.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:744910-746994:+ | gene-YMR246W_MUCL30388 | rna-NM_001182754.1_MUCL30388 | cds-NP_013974.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:733004-735088:+ | gene-YMR246W_MUCL39482 | rna-NM_001182754.1_MUCL39482 | cds-NP_013974.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:740356-742440:+ | gene-YMR246W_MUCL42920 | rna-NM_001182754.1_MUCL42920 | cds-NP_013974.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:759761-761845:+ | gene-YMR246W_NCIM3186 | rna-NM_001182754.1_NCIM3186 | cds-NP_013974.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:732659-734743:+ | gene-YMR246W_NCYC1407 | rna-NM_001182754.1_NCYC1407 | cds-NP_013974.1_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:742552-744636:+ | gene-YMR246W_PE2H3 | rna-NM_001182754.1_PE2H3 | cds-NP_013974.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:743597-745681:+ | gene-YMR246W_PE2H4 | rna-NM_001182754.1_PE2H4 | cds-NP_013974.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:759807-761891:+ | gene-YMR246W_S288C | rna-NM_001182754.1_S288C | cds-NP_013974.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:46246-48330:- | gene-YMR246W_SA1 | rna-NM_001182754.1_SA1 | cds-NP_013974.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:734531-736615:+ | gene-YMR246W_ThermosaccDry | rna-NM_001182754.1_ThermosaccDry | cds-NP_013974.1_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:747085-749169:+ | gene-YMR246W_VR1 | rna-NM_001182754.1_VR1 | cds-NP_013974.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000028.1:149669-151753:+ | gene-YMR246W_ZTW1 | rna-NM_001182754.1_ZTW1 | cds-NP_013974.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:752378-754462:+ | gene-YMR246W_Sparadoxus | rna-NM_001182754.1_Sparadoxus | cds-NP_013974.1_Sparadoxus | 92.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |