Gene name: EST2
Reference locus (S288C): YLR318W
Gene biotype: protein_coding
Description: Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia
Top 10 interactors (score): EST3 (0.999); EST1 (0.999); YKU70 (0.999); YKU80 (0.999); NOP10 (0.997); PXR1 (0.995); NHP2 (0.993); PIF1 (0.992); CBF5 (0.982); KEX2 (0.978); CDC13 (0.969); POL1 (0.965); HSP82 (0.955); POP6 (0.954); EBS1 (0.954); RAD52 (0.951); RRM3 (0.937); HSC82 (0.933); POL12 (0.932); POP1 (0.93)
Homologues (species, bitscore): TERT (Homo sapiens, 115.2); Tert (Mus musculus, 103.6); tert (Danio rerio, 98.6); tert (Xenopus tropicalis, 58.5); TERT (Arabidopsis thaliana, 72.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:714991-717643:+ | gene-YLR318W_AKU4011 | rna-NM_001182207.2_AKU4011 | cds-NP_013422.2_AKU4011 | 99.8 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000170.1:15032-17682:- | gene-YLR318W_BG1 | rna-NM_001182207.2_BG1 | cds-NP_013422.2_BG1 | 99.4 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:750824-753476:+ | gene-YLR318W_Bruggeman | rna-NM_001182207.2_Bruggeman | cds-NP_013422.2_Bruggeman | 99.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:748988-751638:+ | gene-YLR318W_CAT1 | rna-NM_001182207.2_CAT1 | cds-NP_013422.2_CAT1 | 99.6 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:749907-752559:+ | gene-YLR318W_CBS1585 | rna-NM_001182207.2_CBS1585 | cds-NP_013422.2_CBS1585 | 99.8 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:734512-737162:+ | gene-YLR318W_CBS436 | rna-NM_001182207.2_CBS436 | cds-NP_013422.2_CBS436 | 99.5 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:787862-790514:+ | gene-YLR318W_CBS6412 | rna-NM_001182207.2_CBS6412 | cds-NP_013422.2_CBS6412 | 99.8 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:750579-753231:+ | gene-YLR318W_CBS6413 | rna-NM_001182207.2_CBS6413 | cds-NP_013422.2_CBS6413 | 99.8 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:751156-753810:+ | gene-YLR318W_CENPK1137D | rna-NM_001182207.2_CENPK1137D | cds-NP_013422.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:708274-710926:+ | gene-YLR318W_EthanolRed | rna-NM_001182207.2_EthanolRed | cds-NP_013422.2_EthanolRed | 99.9 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:737475-740127:+ | gene-YLR318W_FaliES1 | rna-NM_001182207.2_FaliES1 | cds-NP_013422.2_FaliES1 | 99.9 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000296.1:27723-30373:- | gene-YLR318W_JAY291 | rna-NM_001182207.2_JAY291 | cds-NP_013422.2_JAY291 | 99.4 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:750050-752702:+ | gene-YLR318W_MUCL30387 | rna-NM_001182207.2_MUCL30387 | cds-NP_013422.2_MUCL30387 | 99.9 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:755636-758288:+ | gene-YLR318W_MUCL30388 | rna-NM_001182207.2_MUCL30388 | cds-NP_013422.2_MUCL30388 | 99.9 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:751148-753800:+ | gene-YLR318W_MUCL39482 | rna-NM_001182207.2_MUCL39482 | cds-NP_013422.2_MUCL39482 | 99.8 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:746299-748951:+ | gene-YLR318W_MUCL42920 | rna-NM_001182207.2_MUCL42920 | cds-NP_013422.2_MUCL42920 | 99.9 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:766516-769170:+ | gene-YLR318W_NCIM3186 | rna-NM_001182207.2_NCIM3186 | cds-NP_013422.2_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:760488-763140:+ | gene-YLR318W_NCYC1407 | rna-NM_001182207.2_NCYC1407 | cds-NP_013422.2_NCYC1407 | 99.8 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:748280-750930:+ | gene-YLR318W_PE2H3 | rna-NM_001182207.2_PE2H3 | cds-NP_013422.2_PE2H3 | 99.4 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:748024-750674:+ | gene-YLR318W_PE2H4 | rna-NM_001182207.2_PE2H4 | cds-NP_013422.2_PE2H4 | 99.4 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:766542-769196:+ | gene-YLR318W_S288C | rna-NM_001182207.2_S288C | cds-NP_013422.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000039.1:15113-17763:- | gene-YLR318W_SA1 | rna-NM_001182207.2_SA1 | cds-NP_013422.2_SA1 | 99.6 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:739367-742019:+ | gene-YLR318W_ThermosaccDry | rna-NM_001182207.2_ThermosaccDry | cds-NP_013422.2_ThermosaccDry | 99.9 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:751496-754146:+ | gene-YLR318W_VR1 | rna-NM_001182207.2_VR1 | cds-NP_013422.2_VR1 | 99.7 | 99.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:77783-80437:+ | gene-YLR318W_ZTW1 | rna-NM_001182207.2_ZTW1 | cds-NP_013422.2_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:725527-728165:+ | gene-YLR318W_Sparadoxus | rna-NM_001182207.2_Sparadoxus | cds-NP_013422.2_Sparadoxus | 87.3 | 99.3 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |